The effect of mesoporous silica particles on stem cell differentiation

Abstract

Mesoporous silica particles (MSPs) are characterized by ordered porosity, sharp pore size distributions, high internal surface areas, and large pore volumes.1,2 Control over these structural parameters makes them an ideal candidate for drug encapsulation, perfectly suited to uptake and carry large amounts of drugs that then get released with constant concentration.3–5 The release of the actives can be diffusion controlled or may be triggered by a change in media temperature or pH.6 Creation of simultaneous release profiles is possible by using different pore structures (e. g., 2D hexagonal and 3D cubic) that enable a continuous discharge of a fine tuned mixture of active drugs over a given period of time.