Pub Date : 2023-09-04DOI: 10.15406/jsrt.2023.08.00161
Maria Cecilia Ciaccio Vendola
This work aims to return scientific interest to the valuable biochemical components found in Phytotherapy in times of exponential growth of viral propagation in the world. The topic addressed will be specifically the Echinacea Purpúrea plant, a member of the Compositae or Asteraceae family, which has been researched all over the world , may open up new possibilities for the treatment of oral and systemic diseases , using its own biochemistry as a stimulating factor to increase immunity. Recent studies in humans have shown actions of interest in the immune response with its use, both in aerial part and roots.
{"title":"Echinacea purpurea, a pathway to increased immunity","authors":"Maria Cecilia Ciaccio Vendola","doi":"10.15406/jsrt.2023.08.00161","DOIUrl":"https://doi.org/10.15406/jsrt.2023.08.00161","url":null,"abstract":"This work aims to return scientific interest to the valuable biochemical components found in Phytotherapy in times of exponential growth of viral propagation in the world. The topic addressed will be specifically the Echinacea Purpúrea plant, a member of the Compositae or Asteraceae family, which has been researched all over the world , may open up new possibilities for the treatment of oral and systemic diseases , using its own biochemistry as a stimulating factor to increase immunity. Recent studies in humans have shown actions of interest in the immune response with its use, both in aerial part and roots.","PeriodicalId":91560,"journal":{"name":"Journal of stem cell research & therapeutics","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135453177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-11-01DOI: 10.15406/JSRT.2018.04.00125
J. C. Lisboa
{"title":"Inhibition of cancer promoting proteins","authors":"J. C. Lisboa","doi":"10.15406/JSRT.2018.04.00125","DOIUrl":"https://doi.org/10.15406/JSRT.2018.04.00125","url":null,"abstract":"","PeriodicalId":91560,"journal":{"name":"Journal of stem cell research & therapeutics","volume":"71 4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87726144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-18DOI: 10.15406/JSRT.2018.04.00124
Jaian, Kannaiyan, Veeramanik, An, Eyini Muthukumarasamy, Balaji Paulraj
Myocardial disorders such as acute myocardial infarction endanger millions of people and cause a substantial number of deaths each year; 1 of every 6 deaths all over the world. After an acute myocardial infarction (MI), the heart has a limited capacity of self-renewal undergoing remodelling with resulting left ventricular dysfunction (LVD).1,2 Despite the improvement in several pharmacological, interventional and surgical therapeutic measures, the prognosis for heart failure patients remains very poor. Although an early wave of clinical trials has generated marginal success; medical researchers and regulators face new issues and uncertainties involving longterm safety and efficacy. Put together these observations; account for the continued search for new optional treatments. Among many alternatives, cellular therapy has gained a growing interest as the new field exploiting cells to generate biological substitute, improve tissue function and thereby restoring the damaged tissue with high proliferability and differentiability.3,4 It is also being focused as a potential alternative to complicated tissue or organ transplantation because several factors have been cited as causes for disparities in organ donation and its successful transplantation such as lack of education, religious beliefs, distrust of the health care system, lack of communication between healthcare providers and minority patients and desire of minority members to donate their organs only to members of their same ethnic classification.
{"title":"An in-vitro study of Amniotic membrane, Villous chorion and Wharton’s jelly-derived Mesenchymal stem cells and their potential for cardiac repair","authors":"Jaian, Kannaiyan, Veeramanik, An, Eyini Muthukumarasamy, Balaji Paulraj","doi":"10.15406/JSRT.2018.04.00124","DOIUrl":"https://doi.org/10.15406/JSRT.2018.04.00124","url":null,"abstract":"Myocardial disorders such as acute myocardial infarction endanger millions of people and cause a substantial number of deaths each year; 1 of every 6 deaths all over the world. After an acute myocardial infarction (MI), the heart has a limited capacity of self-renewal undergoing remodelling with resulting left ventricular dysfunction (LVD).1,2 Despite the improvement in several pharmacological, interventional and surgical therapeutic measures, the prognosis for heart failure patients remains very poor. Although an early wave of clinical trials has generated marginal success; medical researchers and regulators face new issues and uncertainties involving longterm safety and efficacy. Put together these observations; account for the continued search for new optional treatments. Among many alternatives, cellular therapy has gained a growing interest as the new field exploiting cells to generate biological substitute, improve tissue function and thereby restoring the damaged tissue with high proliferability and differentiability.3,4 It is also being focused as a potential alternative to complicated tissue or organ transplantation because several factors have been cited as causes for disparities in organ donation and its successful transplantation such as lack of education, religious beliefs, distrust of the health care system, lack of communication between healthcare providers and minority patients and desire of minority members to donate their organs only to members of their same ethnic classification.","PeriodicalId":91560,"journal":{"name":"Journal of stem cell research & therapeutics","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81172313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-11DOI: 10.15406/jsrt.2018.04.00123
G. Pp, Vlasov Gp, Poltavtseva Ra, Voloshin Ll, Leonova-Gariaeva Ea
Multipotent mesenchymal stromal cells derived from human adipose tissue were used for transplantation. Cellular suspension from adipose tissue was diluted with Dulbecco’s Phosphate Buffered Saline (DPBS), (“Gibco”) 1:2, layered on a density gradient of Histopaque 1.077 (“Sigma”) and centrifuged for 30 minutes at 600g. Then, interfacial mononuclear rings were collected into centrifugal test tubes (“Corning”), washed by centrifugation in excess DPBS. The resulting cell sediment was resuspended in a culture medium and placed in culture test tubes (“Corning”, 25cm2) and transferred to a 37°C constant incubator with 5% carbon dioxide gas.
{"title":"Attempt to regenerate the dog’s tooth using the method of a new direction in biology‒Linguistic‒Wave Genetics","authors":"G. Pp, Vlasov Gp, Poltavtseva Ra, Voloshin Ll, Leonova-Gariaeva Ea","doi":"10.15406/jsrt.2018.04.00123","DOIUrl":"https://doi.org/10.15406/jsrt.2018.04.00123","url":null,"abstract":"Multipotent mesenchymal stromal cells derived from human adipose tissue were used for transplantation. Cellular suspension from adipose tissue was diluted with Dulbecco’s Phosphate Buffered Saline (DPBS), (“Gibco”) 1:2, layered on a density gradient of Histopaque 1.077 (“Sigma”) and centrifuged for 30 minutes at 600g. Then, interfacial mononuclear rings were collected into centrifugal test tubes (“Corning”), washed by centrifugation in excess DPBS. The resulting cell sediment was resuspended in a culture medium and placed in culture test tubes (“Corning”, 25cm2) and transferred to a 37°C constant incubator with 5% carbon dioxide gas.","PeriodicalId":91560,"journal":{"name":"Journal of stem cell research & therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91549965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-05DOI: 10.15406/JSRT.2018.04.00122
K. Maeda
Cerebral palsy is a big problem in fetal monitoring. Novel hypoxia index=the sum of all fetal heart rate deceleration durations (min) in fetal monitoring, which is divided by the lowest fetal heart rate (bpm), and multiplied by 100. The hypoxia index of all 6 cerebral palsy cases was 25 or more, while the index of all 16 normal non cerebral palsy cases was 24 or less. Thus, cerebral palsy is prevented, if hyoxia index is 24 or less in the birth, and the newborn babies whose hypoxia index was 25 or more can be treated by early cerebral palsy therapy in neonatal stage. As the hypoxia index is adopted to all of deceleration patterns and continuous bradycardia because its calculation equation did not include lag-time, traditional but subjective early, late and variable deceleration pattern classification will change to numeric hypoxia index in fetal monitoring.
{"title":"Prevention and treatment of cerebral palsy caused by intrapartum damage with novel hypoxia index","authors":"K. Maeda","doi":"10.15406/JSRT.2018.04.00122","DOIUrl":"https://doi.org/10.15406/JSRT.2018.04.00122","url":null,"abstract":"Cerebral palsy is a big problem in fetal monitoring. Novel hypoxia index=the sum of all fetal heart rate deceleration durations (min) in fetal monitoring, which is divided by the lowest fetal heart rate (bpm), and multiplied by 100. The hypoxia index of all 6 cerebral palsy cases was 25 or more, while the index of all 16 normal non cerebral palsy cases was 24 or less. Thus, cerebral palsy is prevented, if hyoxia index is 24 or less in the birth, and the newborn babies whose hypoxia index was 25 or more can be treated by early cerebral palsy therapy in neonatal stage. As the hypoxia index is adopted to all of deceleration patterns and continuous bradycardia because its calculation equation did not include lag-time, traditional but subjective early, late and variable deceleration pattern classification will change to numeric hypoxia index in fetal monitoring.","PeriodicalId":91560,"journal":{"name":"Journal of stem cell research & therapeutics","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76713175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-09-14DOI: 10.15406/JSRT.2018.04.00121
K. Moustaide, A. Nassiri, N. Aqil, H. Baybay, S. Gallouj, F. Mernissi
{"title":"Primary necrotizing fasciitis of the chest wall","authors":"K. Moustaide, A. Nassiri, N. Aqil, H. Baybay, S. Gallouj, F. Mernissi","doi":"10.15406/JSRT.2018.04.00121","DOIUrl":"https://doi.org/10.15406/JSRT.2018.04.00121","url":null,"abstract":"","PeriodicalId":91560,"journal":{"name":"Journal of stem cell research & therapeutics","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80279967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-09-10DOI: 10.15406/JSRT.2018.04.00120
R. Menon, G. Kaushik
Young infants and newborn babies born with cardiac malformations have to undergo complex cardiac surgery with cardiopulmonary bypass in order to survive. The developmental stage of immune function in these cachectic infants and the cytokine and inflammatory storm that ensues after prolonged cardiopulmonary bypass, predisposes them to sepsis syndrome and multiorgan dysfunction in the immediate postoperative period as well as in the short term.1,2
{"title":"Review and report of the role of Breast Milk Stem Cell in balancing immunomodulation after cardio pulmonary bypass","authors":"R. Menon, G. Kaushik","doi":"10.15406/JSRT.2018.04.00120","DOIUrl":"https://doi.org/10.15406/JSRT.2018.04.00120","url":null,"abstract":"Young infants and newborn babies born with cardiac malformations have to undergo complex cardiac surgery with cardiopulmonary bypass in order to survive. The developmental stage of immune function in these cachectic infants and the cytokine and inflammatory storm that ensues after prolonged cardiopulmonary bypass, predisposes them to sepsis syndrome and multiorgan dysfunction in the immediate postoperative period as well as in the short term.1,2","PeriodicalId":91560,"journal":{"name":"Journal of stem cell research & therapeutics","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78175519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-24DOI: 10.15406/jsrt.2018.04.00119
P. Chow, S. Moore, G. Kaushik
Normal adult stem cells are characterized by their ability to selfrenew, as well as their ability to differentiate into various mature cell types. Cancer stem cells were first recognized by Bonnet et al, who showed a sub-portion of acute myelogenous leukemia (AML) stem cells could be identified and separated from AML cells in patients. This subset of AML cells were the only cells capable of transferring AML from the human patients to studied mice.1 The hypothesis of the existence of cancer stem cells gained more attention around 2001 when Reya et al pushed the notion that cancer stems cells are composed of a subset fraction of tumor cells that have the ability to maintain the tumor through self-renewal, conferring drug resistance, and inducing tumor relapse.2 These cancer stem cells have similar physiologic properties to normal adult stem cells, like self-renewal and differentiation. Normal stem cells had been shown to be resistant to cytotoxic agents compared to mature cell types, which is explained by anti-apoptotic mechanisms,3 quiescence,4 and high expression levels of ATP-binding cassette (ABC) transporters.5 Thus, the existence of cancer stem cells explains the reason why many treatments for metastatic tumors ultimately fail. Current treatments like chemotherapy and radiation can shrink, but not cure metastatic tumors. Frequently, these treatments do indeed target the bulk of tumor cells in the human body, but often, the drug therapy is unable to kill the cancer stem cells (due to inherited and/or acquired resistance), and thus the tumor can easily grow back. In recent years, cancer stem cells have been identified and isolated by characteristics of normal stem cells, like using tissue specific CD markers (The cluster of differentiation) and ABC transporter proteins.6 Research about targeted therapy in regard to these cancer stem cells has come in full swing over the past decade.
正常成体干细胞的特点是具有自我更新的能力，以及分化成各种成熟细胞类型的能力。肿瘤干细胞最早是由Bonnet等人发现的，他们发现急性髓性白血病(acute myelelogenous leukemia, AML)干细胞的一个亚部分可以从患者的AML细胞中被识别和分离出来。AML细胞的这个亚群是唯一能够将AML从人类患者转移到研究小鼠的细胞2001年前后，Reya等人提出癌症干细胞是由肿瘤细胞亚群组成的，这些肿瘤细胞具有通过自我更新、赋予耐药性和诱导肿瘤复发的能力，癌症干细胞的存在假说得到了更多的关注这些癌症干细胞具有与正常成体干细胞相似的生理特性，如自我更新和分化。与成熟细胞类型相比，正常干细胞已被证明对细胞毒性药物具有抗性，这可以通过抗凋亡机制，3静止，4和atp结合盒(ABC)转运体的高表达水平来解释因此，癌症干细胞的存在解释了许多转移性肿瘤治疗最终失败的原因。目前的治疗方法，如化疗和放疗，可以缩小，但不能治愈转移性肿瘤。通常，这些治疗确实针对人体中的大部分肿瘤细胞，但通常，药物治疗无法杀死癌症干细胞(由于遗传和/或获得性抵抗)，因此肿瘤很容易生长回来。近年来，利用组织特异性CD标记(The cluster of differentiation)和ABC转运蛋白等正常干细胞的特点，对肿瘤干细胞进行了鉴定和分离在过去的十年里，针对这些癌症干细胞的靶向治疗研究正如火如荼地进行着。
{"title":"Melanoma stem cells: the past, present and future","authors":"P. Chow, S. Moore, G. Kaushik","doi":"10.15406/jsrt.2018.04.00119","DOIUrl":"https://doi.org/10.15406/jsrt.2018.04.00119","url":null,"abstract":"Normal adult stem cells are characterized by their ability to selfrenew, as well as their ability to differentiate into various mature cell types. Cancer stem cells were first recognized by Bonnet et al, who showed a sub-portion of acute myelogenous leukemia (AML) stem cells could be identified and separated from AML cells in patients. This subset of AML cells were the only cells capable of transferring AML from the human patients to studied mice.1 The hypothesis of the existence of cancer stem cells gained more attention around 2001 when Reya et al pushed the notion that cancer stems cells are composed of a subset fraction of tumor cells that have the ability to maintain the tumor through self-renewal, conferring drug resistance, and inducing tumor relapse.2 These cancer stem cells have similar physiologic properties to normal adult stem cells, like self-renewal and differentiation. Normal stem cells had been shown to be resistant to cytotoxic agents compared to mature cell types, which is explained by anti-apoptotic mechanisms,3 quiescence,4 and high expression levels of ATP-binding cassette (ABC) transporters.5 Thus, the existence of cancer stem cells explains the reason why many treatments for metastatic tumors ultimately fail. Current treatments like chemotherapy and radiation can shrink, but not cure metastatic tumors. Frequently, these treatments do indeed target the bulk of tumor cells in the human body, but often, the drug therapy is unable to kill the cancer stem cells (due to inherited and/or acquired resistance), and thus the tumor can easily grow back. In recent years, cancer stem cells have been identified and isolated by characteristics of normal stem cells, like using tissue specific CD markers (The cluster of differentiation) and ABC transporter proteins.6 Research about targeted therapy in regard to these cancer stem cells has come in full swing over the past decade.","PeriodicalId":91560,"journal":{"name":"Journal of stem cell research & therapeutics","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80770422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-17DOI: 10.15406/JSRT.2018.04.00118
R. Upadhyay
Mitochondrial is an important cell organelle that generates ATP that is used as sole energy molecule for all physiological and metabolic activities. It supplies cellular energy and assist in signaling, cell metabolism, cellular differentiation, cell survival and other cell-specific functions. Calcium uptake takes place through mitochondrial outer membrane by voltage-dependent anion channels. After formation of electrochemical gradient and equilibrium on both sides’ mitochondrial functions become normal. It is maintained during oxidative phosphorylation. Thus buffering of cytosolic Ca2+ levels regulate mitochondrial effector functions. Ca2+ transported into mitochondria regulates its metabolism and causes transient depolarisation of mitochondrial membrane. Imbalance in Ca2+ levels cause cardiac myocyte injury that is increased with the decline in pH.1 Dysregulated mitochondrial Ca2+ level and its imbalances generate ischemia neurodegenerative diseases, neuropsychiatric disorders and cancer.2 Accumulation of extra calcium in mitochondria also increases production and modulation of reactive oxygen species. Therefore, balanced Ca2+ buffering is required for normal mitochondrial functions, cell survival and longevity. Mitochondria also involve in control of cell cycle and cell growth. Hence, excessive calcium influx increases ROS generation, induces mitochondrial depolarization and triggers sever pathogenesis. Contrary to this low calcium level affects homoeostasis and redox signaling.3 It also gives rise stress particularly, nitrosative or oxidative stress. More often, excessive calcium uptake of calcium and accumulation of it in cardiac muscle cells result in mitochondrial dysfunctions that impose heart disease. Mitochondria play a central role in cell life and cell death. Availability of Ca2+ in cell from endoplasmic reticulum plays a pivotal role in cell proliferation.
{"title":"Mitochondrial Ca2+ levels lower down rate of metabolic diseases and cardiomyopathies","authors":"R. Upadhyay","doi":"10.15406/JSRT.2018.04.00118","DOIUrl":"https://doi.org/10.15406/JSRT.2018.04.00118","url":null,"abstract":"Mitochondrial is an important cell organelle that generates ATP that is used as sole energy molecule for all physiological and metabolic activities. It supplies cellular energy and assist in signaling, cell metabolism, cellular differentiation, cell survival and other cell-specific functions. Calcium uptake takes place through mitochondrial outer membrane by voltage-dependent anion channels. After formation of electrochemical gradient and equilibrium on both sides’ mitochondrial functions become normal. It is maintained during oxidative phosphorylation. Thus buffering of cytosolic Ca2+ levels regulate mitochondrial effector functions. Ca2+ transported into mitochondria regulates its metabolism and causes transient depolarisation of mitochondrial membrane. Imbalance in Ca2+ levels cause cardiac myocyte injury that is increased with the decline in pH.1 Dysregulated mitochondrial Ca2+ level and its imbalances generate ischemia neurodegenerative diseases, neuropsychiatric disorders and cancer.2 Accumulation of extra calcium in mitochondria also increases production and modulation of reactive oxygen species. Therefore, balanced Ca2+ buffering is required for normal mitochondrial functions, cell survival and longevity. Mitochondria also involve in control of cell cycle and cell growth. Hence, excessive calcium influx increases ROS generation, induces mitochondrial depolarization and triggers sever pathogenesis. Contrary to this low calcium level affects homoeostasis and redox signaling.3 It also gives rise stress particularly, nitrosative or oxidative stress. More often, excessive calcium uptake of calcium and accumulation of it in cardiac muscle cells result in mitochondrial dysfunctions that impose heart disease. Mitochondria play a central role in cell life and cell death. Availability of Ca2+ in cell from endoplasmic reticulum plays a pivotal role in cell proliferation.","PeriodicalId":91560,"journal":{"name":"Journal of stem cell research & therapeutics","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90826674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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