Research on Linkage Disequilibrium Method Based on OpenMP

Jun Lu, Jun Li, Ruiqing Jing, Qiong Wang, Cheng Chang, Jiaxing Guo
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Abstract

Linkage disequilibrium method is applied for the research on inferring population genetics, LD mapping, haploid type diversity analysis and so on. Soybean genotypes are adopted as the data source and linkage disequilibrium parallel algorithm is implemented by OpenMP technology. In this algorithm, single nucleotide polymorphism sites are divided by using sliding windows into groups, adjacent sites allele in a window of each chromosome are parallel calculated and store the LD results. According to the experimental data, the serial and parallel algorithms are compared and analyzed. The conclusion shows that the OpenMP parallel technology can effectively improve the efficiency of linkage disequilibrium analysis method. It is a realistic significance for processing massive biological information data.
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基于OpenMP的连杆不平衡方法研究
连锁不平衡法应用于群体遗传推断、LD定位、单倍体型多样性分析等方面的研究。以大豆基因型为数据源,采用OpenMP技术实现连锁不平衡并行算法。该算法利用滑动窗口对单核苷酸多态性位点进行分组,平行计算每条染色体窗口内相邻位点的等位基因,并存储LD结果。根据实验数据,对串行和并行算法进行了比较和分析。结果表明,OpenMP并行技术可以有效地提高连杆不平衡分析方法的效率。这对处理海量生物信息数据具有现实意义。
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