Synergistic anticoagulant effect of Ocimum sanctum and Zingiber officinale in Blood Samples of Normal Individuals

Abstract

Searches for substances with anticoagulant activity are frequent, and medicinal plants have been considered interesting by some researchers since they are frequently used in popular medicine as remedies for dissolving the blood clots. The aim of this study was to verify the synergism between two plant extracts used as anticoagulant drugs– “tulsi (Ocimum sanctum) and ginger (Zingiber officinale) against blood coagulation, and for this purpose, the synergistic effect of O. sanctum (Tulsi) and Z. officinale (ginger) aqueous extract on clotting time. Coagulation activity of O. sanctum and Z. officinale was measured by capillary glass method on blood samples collected from regular blood donors. The blood was tested against different ratio of aqueous extract of O. sanctum and Z. officinale as follows: 0:0, 0:1, 1:0, 1:1, 1:2, 2:1. Result shows the aqueous extract of O. sanctum and Z. offinale prolonged the clotting time. The extracts; tulsi, and ginger presented the highest synergism rate with anticoagulant drugs