EVALUATION OF IN VITRO ANTIUROLITHIATIC ACTIVITY OF ETHANOLIC EXTRACT OF PAVONIA ZEYLANICA (L) CAV

Abstract

Objective: To evaluate in vitro antiurolithiatic activities of Pavonia zeylanica (L) Cav. Material and Methods: Whole plant of Ethanolic extract of Pavonia zeylanica was prepared and arranged in the three different concentrations (10mg/ml, 20mg/ml, and 30mg/ml). In vitro antiurolithiatic activity of Ethanolic extract of Pavonia zeylanica through turbidometric and titrimetric method was tested in terms of inhibition of calcium oxalate by nucleation and aggregation and dissolution of calcium oxalate, using the standard drug. Results: Standard drug has high percentage inhibition and dissolution ability and thus Ethanolic extract of Pavonia zeylanica also have a good percentage inhibition and dissolution ability was comparable to standard drug. Conclusion: The study concludes that the Ethanolic extract of Pavonia zeylanica have inhibitory effect on calcium oxalate for nucleation and aggregation assay. It also showed good dissolution of calcium oxalate crystals, so this extract has the good protection against Urolithiasis activity