Subhashitha S, Ashitha Meharooz, Haseena ., Nasheel Shereen, Ravi Kumar
{"title":"FORMULATION AND EVALUATION OF MEFENAMIC ACID MICROSPHERES BY IONIC GELATION TECHNIQUE","authors":"Subhashitha S, Ashitha Meharooz, Haseena ., Nasheel Shereen, Ravi Kumar","doi":"10.7897/2277-4572.115236","DOIUrl":null,"url":null,"abstract":"The aim of the present investigation is to prepare mefenamic acid microspheres by ionic gelation technique. A total of three formulations were prepared by altering the polymer ratio. The obtained microspheres were evaluated for drug entrapment efficiency, swelling index, and in vitro drug release. Out of three formulation F3 formulation i.e., (1:2) drug: polymer ratio was found to best formulation with high product yield, Drug entrapment efficiency, Swelling index, and in vitro drug release.","PeriodicalId":16738,"journal":{"name":"Journal of Pharmaceutical and Scientific Innovation","volume":"3 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pharmaceutical and Scientific Innovation","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7897/2277-4572.115236","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
The aim of the present investigation is to prepare mefenamic acid microspheres by ionic gelation technique. A total of three formulations were prepared by altering the polymer ratio. The obtained microspheres were evaluated for drug entrapment efficiency, swelling index, and in vitro drug release. Out of three formulation F3 formulation i.e., (1:2) drug: polymer ratio was found to best formulation with high product yield, Drug entrapment efficiency, Swelling index, and in vitro drug release.
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