Gross and histopathological studies of Diclofenac, Ibuprofen and Nimesulide induced toxicity in broilers

Abstract

The present experimental work was conducted to elucidate the gross and histopathological studies in broiler chicks when treated with Diclofenac sodium, Ibuprofen and Nimesulide. For this study, 120 apparently healthy broiler chicks of either sexes were randomly divided into 10 groups comprising of 10 birds in 9 groups and 30 birds in control group. The broilers of Diclofenac groups were given 10, 20 and 30 mg/kg body weight of Diclofenac sodium for 5 days. Similarly the broilers of Ibuprofen groups were administered 15, 30 and 45 mg/kg body weight of Ibuprofen with feed for 5 days. On the other hand the birds of Nimesulide groups were also given 10, 20 and 30 mg/kg Nimesulide for 5 days. The Nimesuldie groups did not show any lesions of gout but the birds intoxicated with Diclofenac and Ibuprofen revealed mild to moderate lesions of gout characterized by deposition of white chalky urates on the organ surface.   Key words: Diclofenac, Ibuprofen, Nimesulide, broiler, toxicity.