A basic insight into the stability and manufacturing aspects of solid dispersions

J. Vijay, Jyothi T Sahadevan, R. Gilhotra
{"title":"A basic insight into the stability and manufacturing aspects of solid dispersions","authors":"J. Vijay, Jyothi T Sahadevan, R. Gilhotra","doi":"10.4103/2229-5186.98668","DOIUrl":null,"url":null,"abstract":"The development of a bioavailable dosage form is the most challenging task for the researchers. In the arena of advanced drug delivery systems, the solid dispersion techniques seem to be a promising system for the development of an optimized, bioavailable formulation of Class 2 drugs. The methods of formulation of solid dispersion have been summarized. This article is an effort to define a solid dispersion and its classification. The prospective of the stability of solid dispersion has also been discussed. Moreover, the major techniques that have been used so far such as the fusion/melting method, solvent evaporation method, hot melt extrusion method, supercritical fluid methods, have also been detailed.","PeriodicalId":10187,"journal":{"name":"Chronicles of Young Scientists","volume":"12 1","pages":"95"},"PeriodicalIF":0.0000,"publicationDate":"2012-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chronicles of Young Scientists","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/2229-5186.98668","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3

Abstract

The development of a bioavailable dosage form is the most challenging task for the researchers. In the arena of advanced drug delivery systems, the solid dispersion techniques seem to be a promising system for the development of an optimized, bioavailable formulation of Class 2 drugs. The methods of formulation of solid dispersion have been summarized. This article is an effort to define a solid dispersion and its classification. The prospective of the stability of solid dispersion has also been discussed. Moreover, the major techniques that have been used so far such as the fusion/melting method, solvent evaporation method, hot melt extrusion method, supercritical fluid methods, have also been detailed.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
对固体分散体的稳定性和制造方面的基本见解
生物有效剂型的开发是研究人员面临的最具挑战性的任务。在先进的药物输送系统领域,固体分散技术似乎是一种有前途的系统,用于开发优化的,生物可利用的2类药物配方。综述了固体分散体的配制方法。本文试图定义固体色散及其分类。讨论了固体分散稳定性的发展前景。此外,还详细介绍了目前使用的熔融法、溶剂蒸发法、热熔挤压法、超临界流体法等主要技术。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Periodontal status in pregnant women in comparison with non-pregnant individuals Pharmacological evaluation of anxiolytic property of aqueous root extract of Cymbopogon citratus in mice Anesthetic considerations in Townes-Brocks syndrome Formulation and optimization of mucoadhesive microemulsion containing mirtazapine for intranasal delivery Beneficial effect of extracts of Premna integrifolia root on human leucocytes and erythrocytes against hydrogen peroxide induced oxidative damage
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1