Formulation and evaluation of pumpkin fruit (Cucurbita maxima L.) emulgel

Agitya Resti Erwiyani, Sri Mustika Ayu, Winda Ayu Ningtyas, R. L. Vifta
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Abstract

Abstract Background: The fruit of pumpkin (Cucurbita maxima D.), one of genus Cucurbita, family Cucurbitaceae, has antioxidant activity due to the content of metabolites including amino acids, fatty acids, alpha-tocopherol, beta-tocopherol, beta-carotene, beta-cryptoxanthin, and beta-sitosterol. The content of carotenoids and tocopherols in pumpkin has antioxidant activity, reduces skin damage due to sun exposure, and can slow down the aging process. Objective: The study aimed to formulate pumpkin fruit emulgel and evaluate its physical stability during storage Method: Emulgel contains pumpkin fruit extracts at a concentration of 0.5 – 1.5% w/v. Emulgel evaluations were organoleptic, homogeneity, pH, spreadability, adhesion, and viscosity at 2 - 8°C, room temperature, and 40 degree Celcius. The stability test observed the physical properties for 28 days. Results: Pumpkin fruit extracts contain flavonoids based on the TLC test. Emulgel showed organoleptic yellow color with pH in the range of 5, homogeneous, adhesion for more than 1 second, dispersion 5 – 7 cm, and viscosity 2000 – 4000 cP. Storage for 28 days did not show a significant difference at all storage temperatures and centrifugation tests. Conclusion Pumpkin fruit emulgel is stable at all storage temperatures 2 – 8 degree Celcius, 28 ± 2 degree Celcius, and 40 ± 2 degree Celcius. Keywords: emulgel, pumpkin, formulation, physical stability
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南瓜果乳状液的制备与评价
摘要背景:南瓜(Cucurbita maxima D.)是葫芦科瓜属植物之一,其果实富含氨基酸、脂肪酸、α -生育酚、β -生育酚、β -胡萝卜素、β -隐黄质和β -谷甾醇等代谢产物,具有抗氧化活性。南瓜中所含的类胡萝卜素和生育酚具有抗氧化活性,减少因阳光照射而造成的皮肤损伤,并能减缓衰老过程。目的:制备南瓜果乳状液,并考察其贮存过程中的物理稳定性。方法:以0.5 ~ 1.5% w/v的浓度制备南瓜果乳状液。在2 - 8°C、室温和40°C条件下,对凝胶进行感官、均匀性、pH、涂抹性、粘附性和粘度评价。稳定性试验观察了28天的物理性质。结果:薄层色谱法测定南瓜果提取物中含有黄酮类化合物。乳状液呈感官黄色,pH值在5范围内,均匀,黏附时间大于1秒,分散5 ~ 7 cm,黏度2000 ~ 4000 cP,保存28天,在各种储存温度和离心试验下均无显著差异。结论南瓜果乳在2 ~ 8℃、28±2℃、40±2℃3种贮存温度下均稳定。关键词:凝胶,南瓜,配方,物理稳定性
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Pengetahuan, sikap, dan perilaku konsumsi suplemen dan obat tradisional mahasiswa Universitas Jember saat pandemi COVID-19 Hubungan Tingkat Pengetahuan dengan Perilaku Swamedikasi Obat Golongan NSAID di Apotek X Banjarmasin EFEKTIVITAS KOMBINASI EKSTRAK ETANOL 70% DAUN RAMANIA (Bouea macrophylla Griffith) dan GLIBENKLAMID DENGAN METODE INTOLERANSI GLUKOSA PERBANDINGAN KADAR GLUKOSA DARAH DAN HBA1C PADA INSULIN GLARGINE DAN DETEMIR PASIEN DIABETES MELITUS TYPE 2 DI RUMAH SAKIT UMUM DAERAH ULIN BANJARMASIN The study of conformity of the pharmaceutical service in Puskesmas Bogor City towards PMK No. 74, 2016
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