{"title":"Ampullary Pyloric Gland Adenoma with High-grade Dysplasia (Video)","authors":"Shou-jiang Tang , Ruonan Wu , William P. Daley","doi":"10.1016/j.vjgien.2015.03.001","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Ampullary adenoma can be incidental or syndromic and is generally tubular, villous, or tubulovillous in histology. Pyloric gland adenoma (PGA) is uncommon, especially at extra-gastric locations.</p></div><div><h3>Patient & methods</h3><p>In this video manuscript, we present a case of 2<!--> <!-->cm ampullary PGA with high-grade dysplasia (HGD), its endoscopic features, and endoscopic ampullectomy for complete resection.</p></div><div><h3>Results</h3><p>Under endoscopy, this ampullary PGA displayed a smooth mucosal surface with minimal pit patterns, unlike those pit patterns observed in tubular and villous adenomas. Pathologically, there was complete excision of PGA with HGD. The MUC6 immunostaining performed was positive, confirming the diagnosis of PGA.</p></div><div><h3>Conclusions</h3><p>Endoscopists and pathologists should be aware of PGA. Endoscopic resection should be performed for complete removal.</p></div>","PeriodicalId":101274,"journal":{"name":"Video Journal and Encyclopedia of GI Endoscopy","volume":"2 3","pages":"Pages 90-94"},"PeriodicalIF":0.0000,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.vjgien.2015.03.001","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Video Journal and Encyclopedia of GI Endoscopy","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2212097115000047","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Background
Ampullary adenoma can be incidental or syndromic and is generally tubular, villous, or tubulovillous in histology. Pyloric gland adenoma (PGA) is uncommon, especially at extra-gastric locations.
Patient & methods
In this video manuscript, we present a case of 2 cm ampullary PGA with high-grade dysplasia (HGD), its endoscopic features, and endoscopic ampullectomy for complete resection.
Results
Under endoscopy, this ampullary PGA displayed a smooth mucosal surface with minimal pit patterns, unlike those pit patterns observed in tubular and villous adenomas. Pathologically, there was complete excision of PGA with HGD. The MUC6 immunostaining performed was positive, confirming the diagnosis of PGA.
Conclusions
Endoscopists and pathologists should be aware of PGA. Endoscopic resection should be performed for complete removal.
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