The Effectiveness of Virgin Coconut Oil Application on Improving The Skin Integrity of Preterm Infants: Systematic Review and Metaanalysis with Neonatal Skin Condition Score as the Parameter

Syafria Zidni, Diah Adriani Malik, P. Riyanto, Asih Budiastuti, R. Widayati, Muslimin M, Hardian H
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Abstract

Background: Preterm infants have a greater susceptibility to serious infections because their skin barrier has not fully functioned properly. Early birth in preterm infants causes immaturity of the barrier development, in the form of a thinner stratum corneum. Therefore extra care is needed to maintain the integrity of their skin to prevent infection, where the main recommendation is the administration of emollients, such as coconut oil. Virgin coconut oil contains nutrients and lauric acid that are more maintained and higher than coconut oil. Changes in skin integrity can cause extensive skin damage and become risk factors for infection. Erythema or damage to the skin such as erosion, excoriation, or crusting can be an early symptom of life-threatening infection in preterm infants. Assessment of skin integrity can be assessed objectively using the Neonatal Skin Condition Score (NSCS). Virgin coconut oil as an emollient with its antimicrobial activity is expected to allow improvement of the barrier structure of the skin. Aim: The purpose of this study is to review previous studies to provide a systematic summary of the effectiveness of topical coconut oil in improving the skin integrity of premature infants. Methods: Searching the electronic database Pubmed-MEDLINE, Scopus, ProQuest, Cochrane library, ClinicalTrials.gov, and Google Scholar, found five most relevant articles included in the qualitative and two of those five articles included in the meta-analysis. Result: The meta-analysis of the effect of topical VCO compared with control on NSCS values in preterm infants showed the value of heterogeneity test with Tau2=0.04 df=1; p=0.13, I2=55%. The value of the Q statistic was z value = 5.23 (p < 0.001). This shows that the overall administration of topical VCO can significantly improve the value of NSCS on preterm infants. The results of the overall meta-analysis showed that the overall standardized mean difference in NSCS between the intervention group compared to control was -0.93[-1.28 -0.58] (p < 0.001). These results indicate that the overall NSCS value of the intervention group was significantly better than the control group. Conclusion: Data from a systematic review and meta-analysis showed that the application of VCO can provide significantly better results in improving the skin integrity of preterm infants.
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初榨椰子油改善早产儿皮肤完整性的效果:以新生儿皮肤状况评分为参数的系统评价和荟萃分析
背景:早产儿对严重感染的易感性更大,因为他们的皮肤屏障还没有完全发挥作用。早产婴儿会导致角质层发育不成熟,形成较薄的角质层。因此,需要额外的护理来保持皮肤的完整性,以防止感染,其中主要的建议是使用润肤剂,如椰子油。初榨椰子油含有的营养成分和月桂酸比椰子油更持久,含量更高。皮肤完整性的改变可引起广泛的皮肤损伤,并成为感染的危险因素。红斑或皮肤损伤,如糜烂、擦伤或结痂,可能是早产儿危及生命的感染的早期症状。使用新生儿皮肤状况评分(NSCS)可以客观地评估皮肤完整性。初榨椰子油作为一种具有抗菌活性的润肤剂,有望改善皮肤的屏障结构。目的:本研究的目的是回顾以往的研究,提供一个系统的总结,在改善早产儿皮肤完整性外用椰子油的有效性。方法:检索Pubmed-MEDLINE、Scopus、ProQuest、Cochrane图书馆、ClinicalTrials.gov和谷歌Scholar等电子数据库,找到5篇最相关的文章纳入定性分析,其中2篇纳入meta分析。结果:外用VCO与对照组对早产儿NSCS值影响的meta分析显示,Tau2=0.04 df=1的异质性检验值;p = 0.13, I2 = 55%。Q统计值为z值= 5.23 (p < 0.001)。由此可见,局部应用VCO可显著提高NSCS对早产儿的价值。综合meta分析结果显示,干预组与对照组相比,NSCS总体标准化平均差异为-0.93[-1.28 -0.58](p < 0.001)。这些结果表明,干预组的整体NSCS值明显优于对照组。结论:系统回顾和荟萃分析的数据显示,应用VCO在改善早产儿皮肤完整性方面可以提供明显更好的结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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