The effectiveness of adaptive working memory training on EEG and cognitive performance in Alzheimer disease

Pegah Dehghan, S. M. H. Mousavi Nasab, Hossein Ali Ebrahimi Meimand
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Abstract

Due to the progressive aging of population, the prevalence of dementia and age-related cognitive impairment, and in particular Alzheimer’s disease, is highly increasing, and becoming one of the important problems bearing on the health system. Recently, the diagnostic tools and pharmacological treatments have shown a rising potential. Yet, non-pharmacological interventions have attracted significant interest. However, the effectiveness of such interventions has remained controversial. The aim of this study was to investigate whether working memory training changes the EEG and cognitive performance at resting state in patients with Alzheimer’s disease. Twenty patients with mild to moderate Alzheimer's disease were recruited and randomly divided into training and control groups. The training group received twenty-five sessions of adaptive n-back training. Mini Mental Status Examination (MMSE), digit span, and EEG were assessed before and after the intervention period. Working memory training led to a significant increase in MMSE score and alpha power over the frontal and parietal- occipital regions. Nonsignificant increase of the log EEG power was shown for beta, theta, and delta concerning the entire regions. Adaptive n-back training is effective on quantitative EEG in patients with mild to moderate Alzheimer’s disease.
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适应性工作记忆训练对阿尔茨海默病患者脑电图和认知表现的影响
随着人口的逐步老龄化,痴呆症和年龄相关性认知功能障碍,特别是阿尔茨海默病的患病率急剧上升,成为影响卫生系统的重要问题之一。近年来,诊断工具和药物治疗显示出越来越大的潜力。然而,非药物干预引起了极大的兴趣。然而,这些干预措施的有效性仍然存在争议。本研究旨在探讨工作记忆训练是否会改变阿尔茨海默病患者静息状态下的脑电图和认知表现。招募了20名轻度至中度阿尔茨海默病患者,随机分为训练组和对照组。训练组接受25次适应性n-back训练。评估干预前后的最小精神状态检查(MMSE)、手指广度和脑电图。工作记忆训练显著提高了脑MMSE评分和额、顶叶-枕区α功率。整个区域的beta、theta和delta的对数脑电图功率均无显著增加。适应性n-back训练对轻、中度阿尔茨海默病患者定量脑电图有效。
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来源期刊
Cognition, Brain, Behavior. An Interdisciplinary Journal
Cognition, Brain, Behavior. An Interdisciplinary Journal Psychology-Experimental and Cognitive Psychology
CiteScore
0.90
自引率
0.00%
发文量
14
期刊介绍: Cognition, Brain, Behavior. An Interdisciplinary Journal publishes contributions from all areas of cognitive science, focusing on disciplinary and interdisciplinary approaches to information processing and behavior analysis. We encourage contributions from the following domains: psychology, neuroscience, artificial intelligence, linguistics, ethology, anthropology and philosophy of mind. The journal covers empirical studies and theoretical reviews that expand our understanding of cognitive, neural, and behavioral mechanisms. Both fundamental and applied studies are welcomed. On occasions, special issues will be covering particular themes, under the editorship of invited experts.
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