Profile and in-hospital outcomes of deliberate self-harmed patients in a tertiary care centre

J. John, K. Rashmi, R. Jayachandran
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Abstract

Objective: Suicide is an unrecognised and underestimated epidemic of high complexity and accounts for premature loss of at least 1 million lives worldwide, leaving behind irreparable loss and backlash to family, friends and society. This study was carried out with the aim of analysing the clinical presentation, modes of deliberate self-harm (DSH), demographic and biochemical features with outcomes of patients presenting with DSH and admitted through the emergency unit of the medicine department to a tertiary care teaching hospital in South India. Materials and Methods: The clinical presentation, demographic details, psychiatric evaluation and blood investigations of patients admitted with a history of DSH during the study (2020–2021) were analysed, with special emphasis on serum cholesterol, C-reactive protein (CRP) and thyroid-stimulating hormone (TSH). Results: In this study, of the 508 patients studied, the most common mode of self-harm was poisoning by drug overdose (32.28%) followed by plant toxin poisoning and rodenticide ingestion-finding different from other studies of South India during this COVID pandemic. Values of TSH, serum cholesterol, CRP and haematogram were normal in majority of patients. All the patients underwent psychiatry evaluation in which substance abuse, adjustment disorders and personality disorders were the most common diagnosis reached. Conclusions: Clinical profile and methods of DSH have marked regional variation necessitating the need to create a regional database. Serum cholesterol, CRP and TSH are subject to genotypic and regional variations and thus are not reliable as biomarkers of suicidal ideation.
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三级保健中心蓄意自残病人的概况和住院结果
目的:自杀是一种未被认识和低估的高度复杂流行病,在世界范围内造成至少100万人过早死亡,给家庭、朋友和社会造成无法弥补的损失和强烈反应。本研究的目的是分析临床表现、故意自残(DSH)模式、人口统计学和生物化学特征与结果,这些患者是通过印度南部一家三级护理教学医院内科急诊科收治的。材料与方法:分析研究期间(2020-2021年)有DSH病史患者的临床表现、人口统计学细节、精神病学评估和血液调查,重点分析血清胆固醇、c反应蛋白(CRP)和促甲状腺激素(TSH)。结果:在本研究中,508例患者中,最常见的自残方式是药物过量中毒(32.28%),其次是植物毒素中毒和误食灭鼠剂,这与南印度其他研究在本次COVID大流行期间的发现不同。多数患者TSH、血清胆固醇、CRP及血图均正常。所有患者都接受了精神病学评估,其中药物滥用、适应障碍和人格障碍是最常见的诊断。结论:DSH的临床概况和方法有明显的区域差异,需要建立一个区域数据库。血清胆固醇、CRP和TSH受基因型和区域差异的影响,因此作为自杀意念的生物标志物不可靠。
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