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Overview of the artificial intelligence roadmap: Future applications in brain research 人工智能路线图概述:未来在大脑研究中的应用
Pub Date : 2023-07-01 DOI: 10.4103/cmrp.cmrp_85_22
Deepika Bohra, R. Rana, N. Ganguly
The use of artificial intelligence (AI) is an emerging technique in the early identification and categorisation of brain tumour. The currently used method, i.e., magnetic resonance image for the detection of tumour is a time–consuming and complex technique. In the newly developing technique using the AI, the magnetic resonance image scans are used as input data, whereas the currently used method reads the magnetic resonance image manually. The purpose of this article is that the use of novel technique seems very promising in the early detection of brain tumour with high sensitivity and specificity. In this article, two disciplines of AI – machine learning and deep learning are extensively discussed. Through the utilisation of AI techniques, the fields of medicine and health care have experienced remarkable advancements, still there is a shortage of knowledge on artificial–based methods for early tumour diagnosis and classification. In addition, the article discusses the future application of AI techniques in clinical studies.
人工智能(AI)的使用是脑肿瘤早期识别和分类的新兴技术。目前使用的方法,即磁共振成像检测肿瘤是一项耗时且复杂的技术。在利用人工智能开发的新技术中,使用磁共振图像扫描作为输入数据,而目前使用的方法是手动读取磁共振图像。这篇文章的目的是使用新的技术在脑肿瘤的早期检测中具有很高的灵敏度和特异性。在这篇文章中,人工智能的两个学科——机器学习和深度学习进行了广泛的讨论。通过利用人工智能技术,医学和卫生保健领域取得了显着进步,但仍然缺乏基于人工方法的早期肿瘤诊断和分类知识。此外,文章还讨论了人工智能技术在临床研究中的未来应用。
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引用次数: 0
Implications of Inflammatory markers for disease management in patients with chronic kidney disease and COVID-19 infection: A cross-sectional study from North India 慢性肾脏疾病和COVID-19感染患者的炎症标志物对疾病管理的意义:来自北印度的横断面研究
Pub Date : 2023-07-01 DOI: 10.4103/cmrp.cmrp_113_22
V. Khurana, B. Goswami, S. Aggarwal, S. Kaushik
Background: The world witnessed the emergence of a global pandemic. Individuals with chronic illnesses like chronic kidney disease (CKD), already known to be immunologically compromised, have the potential to develop a scenario of an acute-on-chronic condition on coronavirus disease 2019 (COVID-19) contraction. Measurement of serum inflammatory biomarkers like interleukin (IL-6), high-sensitivity C-reactive protein (hsCRP) and ferritin may foresee the prognosis despite the pre-existing low-grade inflammation in these patients. Aims: To determine the utility of serum IL-6, hsCRP and Ferritin levels to determine COVID-19 severity and probable prognosis in CKD patients with COVID-19. Materials and Methods: A cross-sectional study was performed on 100 adult known cases of stage 5 of CKD, recently diagnosed as COVID-19 positive by real-time reverse transcription-polymerase chain reaction. The study population was divided into two groups according to COVID-19 severity: A non-severe and a severe group based on guidelines given in the Clinical Management Protocol: COVID-19. Their clinical and laboratory data obtained on the day of admission were analysed. Results: The severe group (n = 17) had 65% of males and 35% of females. A significant difference was found with respect to the age, body mass index and serum IL-6, hsCRP and ferritin levels between the two groups (P < 0.05). Among the three inflammatory biomarkers, hsCRP was found to have the maximum potential to categorise COVID-19 as severe or non-severe disease. Conclusion: Similar to patients with uncomplicated COVID-19 disease, higher serum levels of inflammatory biomarkers – IL-6, hsCRP and ferritin are seen in patients of CKD with severe COVID-19 illness in comparison to those with non-severe COVID-19, despite having a pre-existing background of low-grade chronic inflammation. The serum levels of IL-6, hsCRP and ferritin can be utilised to determine COVID-19 severity and probable prognosis in CKD patients with COVID-19.
背景:世界目睹了一场全球性流行病的出现。患有慢性肾脏疾病(CKD)等慢性疾病的人,已经知道免疫功能受损,有可能在2019年冠状病毒病(COVID-19)收缩时出现急性慢性疾病。血清炎症生物标志物如白细胞介素(IL-6)、高敏c反应蛋白(hsCRP)和铁蛋白的测量可以预测预后,尽管这些患者已经存在低度炎症。目的:探讨血清IL-6、hsCRP和铁蛋白水平对合并COVID-19的CKD患者COVID-19严重程度和可能预后的影响。材料和方法:对100例已知成年5期CKD患者进行了横断面研究,这些患者最近通过实时逆转录聚合酶链反应诊断为COVID-19阳性。根据COVID-19严重程度将研究人群分为两组:根据《临床管理方案:COVID-19》给出的指南,非严重组和严重组。对入院当天的临床和实验室资料进行分析。结果:重度组(n = 17)男性占65%,女性占35%。两组患者年龄、体重指数、血清IL-6、hsCRP、铁蛋白水平差异均有统计学意义(P < 0.05)。在三种炎症生物标志物中,hsCRP最有可能将COVID-19分类为严重或非严重疾病。结论:与未合并COVID-19疾病的患者相似,尽管存在低级别慢性炎症背景,但与非严重COVID-19患者相比,严重COVID-19疾病的CKD患者血清中炎症生物标志物IL-6、hsCRP和铁蛋白水平较高。血清IL-6、hsCRP和铁蛋白水平可用于判断合并COVID-19的CKD患者COVID-19的严重程度和可能的预后。
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引用次数: 1
Inflammatory markers in patients with chronic kidney disease and coronavirus disease: Implications for disease management 慢性肾脏疾病和冠状病毒疾病患者的炎症标志物:对疾病管理的影响
Pub Date : 2023-07-01 DOI: 10.4103/cmrp.cmrp_119_23
D. Khullar, Abhishek
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引用次数: 0
Rare cause of red eyes: Cogan's syndrome 眼红的罕见原因:科根综合征
Pub Date : 2023-07-01 DOI: 10.4103/cmrp.cmrp_122_22
Shipra Gulati, Rishikesh Dessai, K. Chawla, N. Jain
A 74-year-old hypertensive male presented with redness of both the eyes, bilateral hearing loss and on and off fever since 1 month. A diagnosis of Cogan's syndrome was made, and treatment with systemic steroids and immune-suppression led to complete reversion of his symptoms, red eyes and hearing loss.
74岁高血压男性,双眼发红,双侧听力下降,断断续续发热1个月。他被诊断为科根综合征,接受全身类固醇和免疫抑制治疗后,他的症状、红眼和听力丧失完全恢复。
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引用次数: 0
The pattern of antimicrobial resistance and the presence of the vaginolysin gene in Gardnerella vaginalis isolates from pregnant women 孕妇阴道加德纳菌分离株抗微生物药物耐药性模式及阴道溶素基因的存在
Pub Date : 2023-07-01 DOI: 10.4103/cmrp.cmrp_77_23
Deepika Tripathi, Rishi Saxena, Sippy Agarwal
Background: Bacterial vaginosis (BV) is a common vaginal infection, with Gardnerella vaginalis being the predominant microorganism responsible. BV causes vaginal discharge and irritation and is associated with adverse pregnancy outcomes. Vaginalis produces a pore-forming protein toxin, vaginolysin (VLY), which is essential for virulence and plays a role in the pathogenesis of BV. Aim: This study aimed to investigate the prevalence of the VLY gene in isolates of G. vaginalis from pregnant women and to determine their antibiotic sensitivity patterns. Materials and Methods: Vaginal secretions were collected from 250 pregnant women and processed for G. vaginalis isolation. Presumptive identification of the isolates was done by Amsel's criteria, b-haemolysis and oxidase and catalase tests. A polymerase chain reaction was used to confirm the bacterial identity and detect the VLY gene. Anti-microbial susceptibility patterns were determined for metronidazole, nitrofurantoin, sulphonamides, chloramphenicol and ampicillin. Results: Out of 250 swabs examined, 72 (28.8%) were positive for G. vaginalis, with 59 from BV patients and 13 from non-BV patients. The VLY gene was detected in 33.3% of G. vaginalis isolates from non-BV patients and in 66.6% of those from BV symptomatic patients. Metronidazole and chloramphenicol showed a high sensitivity of 66.6%. Conclusion: The study concludes that regional drug susceptibility studies should be conducted to reduce the phenomenon of bacterial resistance. Further prospective research is needed to understand the function of G. vaginalis in the pathogenesis of BV.
背景:细菌性阴道病(BV)是一种常见的阴道感染,阴道加德纳菌是主要的微生物负责。细菌性阴道炎引起阴道分泌物和刺激,并与不良妊娠结局有关。阴道菌产生一种成孔蛋白毒素,阴道溶血素(VLY),它对毒力至关重要,并在细菌性阴道炎的发病机制中发挥作用。目的:本研究旨在调查孕妇阴道梭菌VLY基因的流行情况,并确定其抗生素敏感性模式。材料与方法:收集250例孕妇阴道分泌物,分离阴道支原体。通过Amsel标准、b溶血、氧化酶和过氧化氢酶试验对分离株进行推定鉴定。采用聚合酶链反应确定细菌身份并检测VLY基因。测定了甲硝唑、呋喃妥英、磺胺类药物、氯霉素和氨苄西林的药敏。结果:250份拭子中有72份(28.8%)阴道梭菌阳性,其中59份来自细菌性阴道炎患者,13份来自非细菌性阴道炎患者。非细菌性阴道炎患者和有细菌性阴道炎症状患者分离株中检出VLY基因的比例分别为33.3%和66.6%。甲硝唑和氯霉素的敏感性为66.6%。结论:为减少细菌耐药现象,应开展区域药敏研究。阴道弧菌在细菌性阴道炎发病中的作用有待进一步的前瞻性研究。
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引用次数: 0
An intriguing case of episodic hypersomnolence- Kleine–Levin syndrome, a diagnosis often missed 这是一个有趣的偶发性嗜睡症病例——克莱恩-莱文综合征,一种经常被忽视的诊断
Pub Date : 2023-07-01 DOI: 10.4103/cmrp.cmrp_67_23
Shreya Chauhan, R. Sabharwal, Praveen Kumar, Paramita Paul
A sleep disorder is characterised by alteration in normal pattern of sleep enough to interfere with the normal functioning of an individual. Sleep disorders are broadly classified as primary sleep disorders such as dyssomnias, hypersomnia and parasomnias and secondary due to medical and mental disorders such as anxiety or substance abuse. We report the case of a 12-year-old boy who presented to us with episodic hypersomnolence, hyperphagia and behavioural abnormalities and was initially managed as epilepsy at another hospital. He was subsequently diagnosed as primary sleep disorder, Kleine–Levin syndrome. We also describe the diagnostic approach to such a case and the crucial role of functional brain imaging in it.
睡眠障碍的特征是正常睡眠模式的改变,足以干扰个人的正常功能。睡眠障碍大致分为原发性睡眠障碍,如睡眠障碍、嗜睡和睡眠异常,以及继发性睡眠障碍,如焦虑或药物滥用。我们报告一个12岁男孩的病例,他向我们提出了发作性嗜睡,嗜食和行为异常,最初在另一家医院作为癫痫治疗。随后,他被诊断为原发性睡眠障碍,克莱恩-莱文综合征。我们还描述了这种情况下的诊断方法和功能脑成像在其中的关键作用。
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引用次数: 0
The commodification of academic publishing – Relevance to cancer palliative care literature 学术出版的商品化-与癌症姑息治疗文献的相关性
Pub Date : 2023-07-01 DOI: 10.4103/cmrp.cmrp_111_23
A. Ghoshal
The commodification of academic publishing refers to the process of turning academic research and scholarship into a marketable product that can be bought and sold for profit. This has become an increasingly prevalent issue in recent years, as academic publishing has become dominated by a small number of large commercial publishers who control access to research and charge exorbitant fees for access to academic articles. In the context of cancer palliative care literature, the commodification of academic publishing has several important implications. First, it means that access to important research on cancer palliative care may be restricted to those who can afford to pay for it, effectively limiting its dissemination and impact. This is particularly problematic in low-income countries or regions where resources for cancer palliative care are already limited. Second, the commodification of academic publishing can lead to the proliferation of predatory journals that publish low-quality or even fraudulent research for profit, which can lead to misleading or harmful information being disseminated to practitioners, policymakers and the public. Finally, the emphasis on profit in academic publishing can create pressure for researchers to prioritise publishing in high-impact journals rather than focusing on research that is most relevant to the needs of cancer palliative care patients and their families. This can create a skewed incentive structure that values prestige over impact, potentially undermining the quality and relevance of research in this field. In summary, the commodification of academic publishing has significant implications for cancer palliative care literature, including issues of access, quality and relevance. It is important for researchers, policymakers and publishers to work together to address these challenges and ensure that the best research is made accessible to all those who need it, regardless of their ability to pay.
学术出版的商品化是指将学术研究和学术成果转化为可销售产品的过程,可以通过买卖来获取利润。近年来,这已经成为一个越来越普遍的问题,因为学术出版已经被少数大型商业出版商所主导,他们控制着研究成果的获取,并对学术文章的获取收取高昂的费用。在癌症姑息治疗文献的背景下,学术出版的商品化有几个重要的含义。首先,这意味着获得关于癌症姑息治疗的重要研究可能仅限于那些有能力支付费用的人,从而有效地限制了它的传播和影响。这在癌症姑息治疗资源已经有限的低收入国家或地区尤其成问题。其次,学术出版的商品化可能导致掠夺性期刊的激增,这些期刊发表低质量甚至欺诈性的研究以获取利润,这可能导致误导或有害的信息被传播给从业者、政策制定者和公众。最后,学术出版对利润的强调会给研究人员带来压力,迫使他们优先在高影响力的期刊上发表论文,而不是专注于与癌症姑息治疗患者及其家属的需求最相关的研究。这可能会造成一种扭曲的激励结构,即重视声望而不是影响,可能会破坏该领域研究的质量和相关性。总之,学术出版的商品化对癌症姑息治疗文献具有重大影响,包括获取、质量和相关性问题。重要的是,研究人员、政策制定者和出版商要共同努力应对这些挑战,并确保所有需要的人都能获得最好的研究,而不管他们的支付能力如何。
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引用次数: 0
A comparative study to assess the job stress levels among faculty members in medical institutions 医疗机构教师工作压力水平之比较研究
Pub Date : 2023-07-01 DOI: 10.4103/cmrp.cmrp_19_23
BSenthil Kumar, Deepti Shastri, KEzhil Vendhan
Background: For many people, stress is so common that it has become a part of life. When it is within a limit, it can help to perform under pressure and motivate to do our best. But when it exceeds and constantly running in an emergency mode, mind and body both are affected. Stress accounts for 80% of all illnesses either directly or indirectly. Stress weakens the immune system and has various effects on the brain and body involving cardiovascular problems, mental illness, depression, etc., Aims: To assess the stress levels among faculty working in medical institutions and to study the need and techniques of stress management. Materials and Methods: The proposed study was conducted as a survey using a structured validated questionnaire among the faculty working in VMKVMCH, Salem and other medical institutions. The survey was analyzed and stress level was assessed and correlated. Results: Efforts must be made to hire adequate, well trained and efficient faculty, discuss grievances with the faculty and take appropriate actions to alleviate stress & anxiety. A significant measure from the administrator's point of view would be to recognize the importance of personal lives of the faculty which may, at times be prioritized over office work. Effective coping strategies need to be adopted by administrators including Stress Management Training, periodical retreats, engaging counselors / medical experts / psychologists to provide support and established stress free working environment. Conclusion: The study concludes that excessive workload due to under staffing and preposterous deadlines contribute majorly to work related stress. It is recommended that the management and administrators recruit and train more faculty and delegate some of the responsibilities to them; ensure equitable distribution of work; address grievances of faculty as soon as possible and provide de-stressing and rejuvenating measures like office parties and supportive counseling by professionals.
背景:对许多人来说,压力是如此普遍,以至于它已经成为生活的一部分。当它在一定范围内时,它可以帮助我们在压力下表现并激励我们做到最好。但当它超过并持续处于紧急状态时,身心都会受到影响。压力直接或间接地占所有疾病的80%。压力会削弱免疫系统,并对大脑和身体产生各种影响,包括心血管疾病、精神疾病、抑郁症等。目的:评估医疗机构教职员工的压力水平,研究压力管理的必要性和技术。材料与方法:本研究采用结构化有效问卷调查的方式,对在VMKVMCH、Salem等医疗机构工作的教师进行调查。对调查结果进行分析,并对压力水平进行评估和关联。结果:必须努力雇用足够的、训练有素的、高效的教师,与教师讨论不满,并采取适当的行动来减轻压力和焦虑。从管理人员的角度来看,一个重要的措施是认识到教师个人生活的重要性,有时这可能比办公室工作更重要。管理人员需要采取有效的应对策略,包括压力管理培训、定期静修、聘请顾问/医学专家/心理学家提供支持和建立无压力的工作环境。结论:研究得出的结论是,由于人手不足和荒谬的截止日期造成的过度工作量是导致工作压力的主要原因。建议管理层和行政人员招聘和培训更多的教员,并将一些职责委托给他们;确保公平分配工作;尽快解决教师的不满,并提供减压和恢复活力的措施,如办公室聚会和专业人士的支持性咨询。
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引用次数: 0
Computerised tomography brain findings in male patients with alcohol dependence syndrome: A hospital based cross sectional study 男性酒精依赖综合征患者的计算机断层扫描脑发现:一项基于医院的横断面研究
Pub Date : 2023-07-01 DOI: 10.4103/cmrp.cmrp_135_22
Vatsal Suchak, A. Kakunje, Vishwanath Reddy
Background: Alcohol dependence syndrome (ADS) is a set of mental, emotional and physiological effects of drinking alcohol daily. This study aimed to assess the computerised tomography (CT) brain findings in patients with ADS and to compare it with age-matched controls. Aims: To study the relationship of CT-Brain findings in Male patients with alcohol dependence syndrome and compare it with controls. Materials and Methods: This retrospective study was carried out after obtaining clearance from the institution's ethics committee between 1 January 2021 and April 2022. Medical records of 64 patients were examined, of which 32 patients with the diagnosis of ADS who had already undergone CT brain Neuroimaging and 32 age- and sex-matched normal controls, were randomly selected and parameters were compared to look at cortical atrophy, cella media index (CMI), the maximum width of the third, fourth ventricle, frontal subarachnoid space, Evans ratio, the maximum width of the anterior interhemispheric fissure and maximum width of the Sylvian fissure (MSF). Results: The study detected that the mean age of cases was 41.96 years, and in controls, it was 40.91 years with no significant difference. There was a significant difference in the mean level of CMI, the maximum width of the third and fourth ventricle, frontal subarachnoid space, the maximum width of the anterior hemispheric fissure and the MSF amongst the cases compared to controls. Conclusion: Compared to controls, there was a significant change in CT brain findings amongst the ADS patients.
背景:酒精依赖综合征(ADS)是每天饮酒引起的一系列心理、情绪和生理影响。本研究旨在评估ADS患者的计算机断层扫描(CT)脑部结果,并将其与年龄匹配的对照组进行比较。目的:探讨男性酒精依赖综合征患者ct -脑表现的关系,并与对照组进行比较。材料和方法:本回顾性研究于2021年1月1日至2022年4月期间获得该机构伦理委员会的批准后进行。随机选取64例患者的病历,其中32例已行CT脑神经影像学诊断为ADS的患者与32例年龄、性别匹配的正常对照,比较皮质萎缩、中细胞指数(CMI)、第三、第四脑室最大宽度、额部蛛网膜下腔、Evans比、前半球间裂最大宽度和Sylvian裂最大宽度(MSF)等参数。结果:本组病例平均年龄为41.96岁,对照组平均年龄为40.91岁,差异无统计学意义。CMI的平均水平、第三脑室和第四脑室的最大宽度、额部蛛网膜下腔、前半球裂的最大宽度和MSF与对照组相比有显著差异。结论:与对照组相比,ADS患者的CT表现有显著变化。
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引用次数: 0
Emotional intelligence and personality among undergraduate students in a rural district of South India 南印度农村地区大学生的情商和个性
Pub Date : 2023-07-01 DOI: 10.4103/cmrp.cmrp_105_22
Kannappa V. Shetty, J. Jaise, Upasana Baruah, Urmila Bamney, G. Sachetha
Background: Emotional intelligence is a key concept that contributes to the development of stronger relationships, academic and professional success and can lead to better mental, social and even physical health. It helps an individual to understand themselves and others, and has special significance in the life of a student. There is some preliminary evidence that emotional intelligence could also be associated with the personality traits of an individual. This association needs to be explored further and the current study aims to explore the same in the student population. Materials and Methods: The study aimed to assess the level of emotional intelligence and its correlation with the personality traits of college students. A descriptive research design was used and data were collected from 120 undergraduate students using simple random sampling. The emotional intelligence scale and big five inventory questionnaire were used to collect the data. Results: Most of the population belonged to an average level of emotional intelligence (58.3%), reported a high level of openness (49.2%), low level of conscientiousness (55.8%), high level of extraversion (76.7%), high level of agreeableness (47.5%) and low level of neuroticism (65.8%). Emotional intelligence was negatively correlated to neuroticism (r = −0.349**). Conclusion: The study results indicate that there is a significant correlation between emotional intelligence and neuroticism among undergraduate students. This aspect can be further explored to develop an intervention to enhance emotional intelligence among undergraduate students.
背景:情商是一个关键的概念,有助于发展更牢固的人际关系,学业和职业上的成功,并能带来更好的心理、社会甚至身体健康。它有助于个人了解自己和他人,在学生的生活中具有特殊的意义。有一些初步证据表明,情商也可能与个人的性格特征有关。这种联系需要进一步探索,目前的研究旨在探索学生群体中的相同情况。材料与方法:本研究旨在评估大学生情绪智力水平及其与人格特质的相关性。采用描述性研究设计,采用简单随机抽样的方法对120名大学生进行数据收集。采用情绪智力量表和大五量表进行数据收集。结果:大部分人群情绪智力水平为平均水平(58.3%),开放性高(49.2%)、尽责性低(55.8%)、外向性高(76.7%)、宜人性高(47.5%)、神经质低(65.8%)。情绪智力与神经质呈负相关(r = - 0.349**)。结论:本研究结果表明,大学生情绪智力与神经质存在显著相关。这方面可以进一步探讨,以开发干预措施,以提高大学生的情绪智力。
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引用次数: 0
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Current medicine research and practice
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