Chalcone Derivatives for Biological Potentials: A Strategy of Molecular Hybridization for Drug Design

YMER Digital Pub Date : 2022-07-29 DOI:10.37896/ymer21.07/a5
Amit Kumar
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Abstract

Naturally and synthetically derived hybrid molecules are promising sources for new drug development due to their multiple modes of action and other advantages. Chalcone, two important classes of synthetic chemistry affording diverse pharmacological activities, make themselves ideal blocks for building a chalcone hybrid scaffold as a bioactive agent. Provoked by the promising medicinal applications of such hybrids, the scientific community has reported dozens of chalcone hybrids with a wide spectrum of biological properties including anticancer, antimicrobial, antimalarial, antioxidant, antianxiety and so on, through synthetic hybridization strategy. It is expected to assist medicinal chemists in the effective and successful development of chalcone hybrids. In view of these observations, we herein report the literature review of Chalcone hybrids which possessing antimicrobial antioxidant and antianxiety potential. Key words: Chalcone, Molecular hybridization, Biological potentials.
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查尔酮衍生物的生物电位:一种分子杂交药物设计策略
天然和合成衍生的杂化分子由于其多种作用模式和其他优点,是新药开发的有希望的来源。查尔酮是两类重要的合成化学物质,具有不同的药理活性,是构建查尔酮杂化支架作为生物活性剂的理想材料。由于查尔酮杂合物在医学上的应用前景广阔,科学界已经报道了数十种杂合物,这些杂合物具有抗癌、抗菌、抗疟、抗氧化、抗焦虑等广泛的生物学特性。它有望帮助药物化学家有效和成功地开发查尔酮杂交种。鉴于这些观察结果,本文报道了具有抗菌、抗氧化和抗焦虑潜力的查尔酮杂种化合物的文献综述。关键词:查尔酮,分子杂交,生物电位
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