Development of Graphene Oxide-Trihexyphenidyl Hydrochloride Nanohybrid and Release behavior

Abstract

The demand of an efficient nanocarrier in drug delivery, graphene and its derivatives are emerging as a rising star due to its remarkable chemical and structural properties. Graphene oxide (GO) has high surface area and ability to load high amount of aromatic drugs. Hence, the objective of the research was to load Trihexyphenidyl hydrochloride (THP), antiparkinsonian drug on GO ultrasonically by π-π stacking interaction. GO was synthesized by the modified Hummer method. The conjugation of GOTHP was generated by using Design-Expert Software and release study of GO-THP nanohybrids was performed in the dissolution tester by using a dialysis membrane. By varying an amount of GO and THP, the effect on loading efficiency and drug release was studied. THP showed sustained release behavior with release efficiency of 89% to 98% over 8 h. GO-THP complex was characterized by UV-vis spectrophotometer, FTIR, FESEM and XRD analysis. GO-THP complex showed better-sustained release of the drug and can be useful for the reduction dose frequency as well as adverse effect with better patient compliance.