Clinical value analysis of IgG antibody detection in diagnosis of chronic pulmonary aspergillosis

Abstract

Objective To evaluate the clinical value of aspergillus-specific immunoglobulin G (IgG) antibody in diagnosis of chronic pulmonary aspergillosis. Methods 47 patients who were admitted to Peking University Third Hospital from April 2018 to April 2019 and suspected to have chronic pulmonary aspergillosis infection were studied.The serum 1, 3-β-glucan test (G test), galactomannan (GM) test and aspergillus-specific IgG test were performed on these patients to evaluate the results of the three test methods. Results According to the clinical classification criteria, there were 26 patients in aspergillosis group, 21 patients in the non-aspergillosis group.The result of serum G test was 36 (10, 160) ng/L, GM test was 0.23(0.15, 0.30) and aspergillus-specific IgG detection was 151.43 (84.61, 322.63) AU/ml in aspergillosis group.In non-aspergillosis group, the result of serum G test was 10 (10, 45) ng/L, GM test was 0.26(0.15, 0.54) and aspergillus-specific IgG detection was 57.90 (42.79, 137.42) AU/ml.The sensitivity of aspergillus-specific IgG detection was 65.4%.The area under receiver operator characteristic curve of aspergillus-specific IgG detection method was 0.785 3. Conclusions In the clinical diagnosis and treatment of patients with chronic pulmonary aspergillosis, aspergillus-specific IgG antibody detection has a higher detection rate for aspergillus, which can make up for the defects of GM detection, and is beneficial for early diagnosis and timely effective treatment. Key words: Pulmonary aspergillosis; Early diagnosis; Aspergillus-specific immunoglobulin G detection