CHITOSAN-COATED CALCIUM PHOSPHATE PARTICLES AS CARRIERS FOR DRUG DELIVERY TO OCULAR TISSUES

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Abstract

Chitosan-covered calcium phosphate particles are promising carriers for the delivery of low-molecular-weight drugs to ocular tissues. The inclusion of the angiotensin-converting enzyme inhibitor enalaprilat into these particles increases the retention time of the drug in the tear, enhances the effectiveness of intraocular pressure decrease, and prolongs the drug action.
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壳聚糖包被磷酸钙颗粒作为眼部组织药物递送载体
壳聚糖包覆的磷酸钙颗粒是一种很有前途的将低分子药物输送到眼组织的载体。血管紧张素转换酶抑制剂依那普利特掺入这些颗粒中,增加了药物在泪液中的滞留时间,增强了降低眼压的有效性,延长了药物的作用时间。
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