Study of antimicrobial property of some hypoglycemic drugs

Abstract

In the present work, a comparative antimicrobial study of different hypoglycemic drugs (Metformin, Phenformin, and Rosiglitazone) was carried out. The main objective was to ascertain the antimicrobial activity by using non-antibiotics as the test substances. The antimicrobial activity was carried out against different bacteria and fungi namely Bacillus liceniformis , Escherichia coli , Proteus vulgaris , Pseudomonas aeruginosa , Shigella flexneri , Bacillus subtilis , Staphylococcus aureus subspp., and Staphylococcus epidermidis by using disc diffusion method and agar dilution method. Ciprofloxacin was taken as the standard antibiotic. The entire procedure was carried out in an aseptic area under the laminar flow by inoculating the bacterial strain to the agar media in which the drug solution was added. Different concentrations (300 and 400 μg/ml) of the standard antibiotic and selected drugs were subjected for minimum inhibitory concentration, and zone of inhibition tests and the antimicrobial activity of the selected drugs were determined.