Evaluation of analgesic activity and acute toxicity of ketoprofen-nicotinamide multicomponent solids

Q4 Pharmacology, Toxicology and Pharmaceutics Pharmaceutical Sciences Asia Pub Date : 2022-01-01 DOI:10.29090/psa.2022.03.22.013

Yudi Wicaksono, Lusia Oktora Ruma Kumala Sari, Biru Putri Ayu Istiqomah, Shofiatul Izzah Al Amaliyah, D. Setyawan

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Abstract

The objective of this study was to evaluate the analgesic activity and acute toxicity of the ketoprofen-nicotinamide multicomponent solid. The preparation of multicomponent solids was carried out by the solvent evaporation method. The characterization of multicomponent solids was carried out by powder x-ray diffractometer (PXRD), differential scanning calorimeter (DSC), and fourier transform infrared spectrometer (FTIR). Solubility test was carried out by shaking method and evaluation of analgesic activity-toxicity was carried out in vivo in mice strain BALB/c. The results showed that the ketoprofen-nicotinamide multicomponent solid formed a new solid phase with different characteristics from the initial components. The ketoprofen-nicotinamide multicomponent solid showed a significantly ( p <0.05) increased solubility, which was 1.3 times compared to the solubility of pure ketoprofen. In the evaluation of analgesic activity, the treatment group of multicomponent solid at a dose of 3.25 mg/kg body weight showed significantly increased pain inhibition ( p <0.05) compared to the treatment group of pure ketoprofen. The toxicity evaluation in experimental animals showed that the multicomponent solids did not cause a significant ( p >0.05) increase in SGOT and SGPT levels compared to the control group. Observations on the stomach histology of experimental animals showed that the ketoprofen-nicotinamide multicomponent solid gave a lighter infiltration of neutrophil inflammatory cells when compared to the pure ketoprofen group.

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酮洛芬-烟酰胺多组分固体镇痛活性及急性毒性评价

本研究的目的是评价酮洛芬-烟酰胺多组分固体的镇痛活性和急性毒性。采用溶剂蒸发法制备多组分固体。采用粉末x射线衍射仪(PXRD)、差示扫描量热仪(DSC)和傅里叶变换红外光谱仪(FTIR)对多组分固体进行表征。采用摇瓶法进行溶解度试验，并对BALB/c小鼠进行体内镇痛活性毒性评价。结果表明，酮洛芬-烟酰胺多组分固体形成了与初始组分具有不同特征的新固相。酮洛芬-烟酰胺多组分固体与对照组相比，SGOT和SGPT水平显著升高(p 0.05)。实验动物的胃组织学观察表明，与纯酮洛芬组相比，酮洛芬-烟酰胺多组分固体对中性粒细胞炎症细胞的浸润更轻。

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来源期刊

Pharmaceutical Sciences Asia Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

0.90

自引率

0.00%

发文量

期刊介绍： The Pharmaceutical Sciences Asia (PSA) journal is a double-blinded peer-reviewed journal in English published quarterly, by the Faculty of Pharmacy, Mahidol University, Thailand. The PSA journal is formerly known as Mahidol University Journal of Pharmaceutical Sciences and committed to the timely publication of innovative articles and reviews. This journal is available in both printed and electronic formats. The PSA journal aims at establishing a publishing house that is open to all. It aims to disseminate knowledge; provide a learned reference in the field; and establish channels of communication between academic and research expert, policy makers and executives in industry and investment institutions. The journal publishes research articles, review articles, and scientific commentaries on all aspects of the pharmaceutical sciences and multidisciplinary field in health professions and medicine. More specifically, the journal publishes research on all areas of pharmaceutical sciences and related disciplines: Clinical Pharmacy Drug Synthesis and Discovery Targeted-Drug Delivery Pharmaceutics Biopharmaceutical Sciences Phytopharmaceutical Sciences Pharmacology and Toxicology Pharmaceutical Chemistry Nutraceuticals and Functional Foods Natural Products Social, Economic, and Administrative Pharmacy Clinical Drug Evaluation and Drug Policy Making Antimicrobials, Resistance and Infection Control Pharmacokinetics and Pharmacodynamics.