T. M. Freyman, I. Yannas, Y. Pek, Rayka Yokoo, L. Gibson
{"title":"Micromechanics of Fibroblast Contraction of a Collagen-Gag Matrix","authors":"T. M. Freyman, I. Yannas, Y. Pek, Rayka Yokoo, L. Gibson","doi":"10.1115/imece2001/bed-23150","DOIUrl":null,"url":null,"abstract":"\n Contractile fibroblasts play a major role in the synthesis and remodeling of scar tissue following dermal injury. Inhibition of dermal wound contraction by contractile fibroblasts, using a collagen-GAG matrix, has been linked to the blocking of scar formation[1]. Scar tissue is mechanically and functionally inferior to the dermal tissue which it replaces. Specifically, scar tissue is weaker, physically disfiguring, and can lead to restricted joint mobility.","PeriodicalId":7238,"journal":{"name":"Advances in Bioengineering","volume":"419 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2001-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in Bioengineering","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1115/imece2001/bed-23150","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
Contractile fibroblasts play a major role in the synthesis and remodeling of scar tissue following dermal injury. Inhibition of dermal wound contraction by contractile fibroblasts, using a collagen-GAG matrix, has been linked to the blocking of scar formation[1]. Scar tissue is mechanically and functionally inferior to the dermal tissue which it replaces. Specifically, scar tissue is weaker, physically disfiguring, and can lead to restricted joint mobility.
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