Pub Date : 2001-11-11DOI: 10.1115/imece2001/bed-23082
Christopher M. Brown, M. Fauver, P. Reinhall, E. Seibel
There is a need for smaller, more flexible, optical imaging tools for use in minimally invasive diagnostic and therapeutic procedures [1]. Towards this end, a novel technique of image acquisition has been developed based upon the controlled vibration of a waveguide and detection of light backscattered from the waveguide onto an object [2]. The anticipated result of this research is the creation of an optical scanner capable of operating at high frequency, with a large field-of-view (FOV) in a 1 mm diameter enclosure. The mechanics of this system have been explored for use in near-field scanning optical microscopy applications [3], and are now examined for use in a scanning fiber endoscope. Discussed in this report are the vibration characteristics of two possible waveguide geometries: a cylindrical and a tapered optical fiber.
{"title":"Mechanical Design and Analysis for a Scanning Fiber Endoscope","authors":"Christopher M. Brown, M. Fauver, P. Reinhall, E. Seibel","doi":"10.1115/imece2001/bed-23082","DOIUrl":"https://doi.org/10.1115/imece2001/bed-23082","url":null,"abstract":"\u0000 There is a need for smaller, more flexible, optical imaging tools for use in minimally invasive diagnostic and therapeutic procedures [1]. Towards this end, a novel technique of image acquisition has been developed based upon the controlled vibration of a waveguide and detection of light backscattered from the waveguide onto an object [2]. The anticipated result of this research is the creation of an optical scanner capable of operating at high frequency, with a large field-of-view (FOV) in a 1 mm diameter enclosure. The mechanics of this system have been explored for use in near-field scanning optical microscopy applications [3], and are now examined for use in a scanning fiber endoscope. Discussed in this report are the vibration characteristics of two possible waveguide geometries: a cylindrical and a tapered optical fiber.","PeriodicalId":7238,"journal":{"name":"Advances in Bioengineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75872347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2001-11-11DOI: 10.1115/imece2001/bed-23078
M. Trabia, K. G. Zobotkin, Robert C. Wang
This paper presents a novel method for internal fixation of unstable mandibular fractures. The fixation method uses a three-screw V-shaped plate and a wire. Two screws are placed normal to the fracture line. The plate is first attached to one of the screws. A wire is then passed around the plate and the opposite screw and tightened to bring the two sides of the fracture together and align them. The plate is then fixed to the other side of the fracture using two additional screws. The fixation system is designed such that the plate carries most of the load. Finite element modeling of the system shows that the method is reliable, producing low stresses. The proposed method presents a simple and quick alternative to the usual plates currently used for mandibular fixation.
{"title":"Design of a V-Plate-Wire Mandibular Fixation System","authors":"M. Trabia, K. G. Zobotkin, Robert C. Wang","doi":"10.1115/imece2001/bed-23078","DOIUrl":"https://doi.org/10.1115/imece2001/bed-23078","url":null,"abstract":"\u0000 This paper presents a novel method for internal fixation of unstable mandibular fractures. The fixation method uses a three-screw V-shaped plate and a wire. Two screws are placed normal to the fracture line. The plate is first attached to one of the screws. A wire is then passed around the plate and the opposite screw and tightened to bring the two sides of the fracture together and align them. The plate is then fixed to the other side of the fracture using two additional screws. The fixation system is designed such that the plate carries most of the load. Finite element modeling of the system shows that the method is reliable, producing low stresses. The proposed method presents a simple and quick alternative to the usual plates currently used for mandibular fixation.","PeriodicalId":7238,"journal":{"name":"Advances in Bioengineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74364668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2001-11-11DOI: 10.1115/imece2001/bed-23021
J. Holmes
Graduate courses in finite elasticity and soft tissue biomechanics must deliver substantial theoretical content to prepare students for the complexities of soft tissue mechanics. In the laboratory students often discover that practical tasks such as calculating three-dimensional finite strain from marker data or reconstructing three-dimensional marker positions from two-dimensional views are not obvious despite mastery of the underlying theory. This course sought to replace as much didactic time as possible with hands-on MATLAB programming and simulations to illustrate basic theory and help students make the bridge to practical applications.
{"title":"A Matlab-Based Cardiac Mechanics Course: Exportable Tools for Graduate-Level Soft Tissue Biomechanics","authors":"J. Holmes","doi":"10.1115/imece2001/bed-23021","DOIUrl":"https://doi.org/10.1115/imece2001/bed-23021","url":null,"abstract":"\u0000 Graduate courses in finite elasticity and soft tissue biomechanics must deliver substantial theoretical content to prepare students for the complexities of soft tissue mechanics. In the laboratory students often discover that practical tasks such as calculating three-dimensional finite strain from marker data or reconstructing three-dimensional marker positions from two-dimensional views are not obvious despite mastery of the underlying theory. This course sought to replace as much didactic time as possible with hands-on MATLAB programming and simulations to illustrate basic theory and help students make the bridge to practical applications.","PeriodicalId":7238,"journal":{"name":"Advances in Bioengineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78443358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2001-11-11DOI: 10.1115/imece2001/bed-23029
J. Choi, C. Dharan
Cortical bone is a complex hierarchical composite lamallae structure consisting, in general, of a mineral phase (calcium hydroxyapatite), an organic phase (collagen) and fluid [1]. In the analysis of bone, the liquid phase is usually neglected, an assumption that is reasonable for steady state or quasi-static loading. However, when cortical bone is loaded dynamically in the axial direction, the presence of the constrained fluid generates time-dependent stresses in the tangential direction. Since the tangential stress acts perpendicular to the weak transverse direction of the bone, it can create damage in this direction. Cyclic axial compressive loading will result in cyclic tensile loading in the tangential direction which can eventually result in fatigue damage. Such damage has actually been observed in studies conducted on heavily exercised race horses where damage was observed in the form of micro cracks oriented perpendicular to the tangential direction and whose fracture planes lie along the axial direction [2]. In this work, cortical bone is modeled as a biphasic material consisting of a permeable composite material filled with fluid. The geometry considered is that of a hollow cylinder made up of multiple concentric permeable lamellae filled with fluid (Fig. 1). When this structure is loaded axially in compression, a tensile tangential stress is developed which decays with time. The decay rate is a function of permeability and radial position. The greater the permeability, the faster the decay rate. The tangential stress peaks at the inner radius and decreases with radial position (Fig. 2). The tangential stress also peaks earlier at the inner radius. The rate of decay is slower at the outside surface where the bone is subjected to the tangential stress for a much longer time than at the inner surface (Fig. 2). This view of bone as a biphasic structure subjected to dynamic loading may provide a rationale for some of the damage modes observed in vivo in bones subjected to cyclic and impact loading.
{"title":"Tangential Stress in Cortical Bone Subjected to Dynamic Axial Loading","authors":"J. Choi, C. Dharan","doi":"10.1115/imece2001/bed-23029","DOIUrl":"https://doi.org/10.1115/imece2001/bed-23029","url":null,"abstract":"\u0000 Cortical bone is a complex hierarchical composite lamallae structure consisting, in general, of a mineral phase (calcium hydroxyapatite), an organic phase (collagen) and fluid [1]. In the analysis of bone, the liquid phase is usually neglected, an assumption that is reasonable for steady state or quasi-static loading. However, when cortical bone is loaded dynamically in the axial direction, the presence of the constrained fluid generates time-dependent stresses in the tangential direction. Since the tangential stress acts perpendicular to the weak transverse direction of the bone, it can create damage in this direction. Cyclic axial compressive loading will result in cyclic tensile loading in the tangential direction which can eventually result in fatigue damage. Such damage has actually been observed in studies conducted on heavily exercised race horses where damage was observed in the form of micro cracks oriented perpendicular to the tangential direction and whose fracture planes lie along the axial direction [2].\u0000 In this work, cortical bone is modeled as a biphasic material consisting of a permeable composite material filled with fluid. The geometry considered is that of a hollow cylinder made up of multiple concentric permeable lamellae filled with fluid (Fig. 1). When this structure is loaded axially in compression, a tensile tangential stress is developed which decays with time. The decay rate is a function of permeability and radial position. The greater the permeability, the faster the decay rate. The tangential stress peaks at the inner radius and decreases with radial position (Fig. 2). The tangential stress also peaks earlier at the inner radius. The rate of decay is slower at the outside surface where the bone is subjected to the tangential stress for a much longer time than at the inner surface (Fig. 2).\u0000 This view of bone as a biphasic structure subjected to dynamic loading may provide a rationale for some of the damage modes observed in vivo in bones subjected to cyclic and impact loading.","PeriodicalId":7238,"journal":{"name":"Advances in Bioengineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75119146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2001-11-11DOI: 10.1115/imece2001/bed-23147
R. Mauck, M. Soltz, G. Ateshian, C. Hung
Articular cartilage is the load-bearing substance that covers the bony surfaces of articulating bones. With its high water content and small pore size, deformation of cartilage induces a very high hydrostatic pressure within the cartilage. This hydrostatic pressure has been shown both theoretically and experimentally to support upwards of 90% of the applied load (1), and can be on the order of 6–12 MPa. Chondrocytes, the cells within cartilage respond to this pressure by altering their rates of biosynthesis. Studies utilizing radionucleotide incorporation in both explant and monolayer cultures (2–4) have shown that in general dynamic pressurization increases synthesis, while static pressurization decreases synthesis. More recently, Smith et al have shown that dynamic pressurization (10MPa, 1 Hz) of cells in monolayer culture can upregulate matrix gene expression (5,6). Further, a study in PGA constructs has shown that long term application of dynamic pressure can increase matrix deposition (7). In this study, we seek to expand on these findings by examining the response in gene expression of articular chondrocytes encapsulated in alginate, a charged, 3D hydrogel.
{"title":"Dynamic Hydrostatic Pressurization Increases Matrix Gene Expression by Chondrocytes in 3D Culture","authors":"R. Mauck, M. Soltz, G. Ateshian, C. Hung","doi":"10.1115/imece2001/bed-23147","DOIUrl":"https://doi.org/10.1115/imece2001/bed-23147","url":null,"abstract":"\u0000 Articular cartilage is the load-bearing substance that covers the bony surfaces of articulating bones. With its high water content and small pore size, deformation of cartilage induces a very high hydrostatic pressure within the cartilage. This hydrostatic pressure has been shown both theoretically and experimentally to support upwards of 90% of the applied load (1), and can be on the order of 6–12 MPa. Chondrocytes, the cells within cartilage respond to this pressure by altering their rates of biosynthesis. Studies utilizing radionucleotide incorporation in both explant and monolayer cultures (2–4) have shown that in general dynamic pressurization increases synthesis, while static pressurization decreases synthesis. More recently, Smith et al have shown that dynamic pressurization (10MPa, 1 Hz) of cells in monolayer culture can upregulate matrix gene expression (5,6). Further, a study in PGA constructs has shown that long term application of dynamic pressure can increase matrix deposition (7). In this study, we seek to expand on these findings by examining the response in gene expression of articular chondrocytes encapsulated in alginate, a charged, 3D hydrogel.","PeriodicalId":7238,"journal":{"name":"Advances in Bioengineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77669845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2001-11-11DOI: 10.1115/imece2001/bed-23085
Naphysah O. Duncan, P. Walker, H. Potter
Current total knee replacements have been successful in relieving the pain associated with arthritis, as well as increasing patient mobility and allowing them to partake in sports activities to a limited degree. In the elderly patient group, the ten-year survivorship has been as high as 95%. Approximately, one-third of the patients who are candidates for total knee replacement fall into the younger patient group category. In this group, where life expectancy can exceed 20 years[1], the survivorship of a TKR is limited. This becomes an important issue since one or more revision surgeries may be necessary. As a result, the chances of infection, pain associated with surgery and rehabilitation, and loss of viable bone are increased. Achieving a high degree of mobility is also a priority for this group since they tend to lead a more active lifestyle.
{"title":"Customized Resurfacing of the Knee: Design of the Shell Knee Replacement","authors":"Naphysah O. Duncan, P. Walker, H. Potter","doi":"10.1115/imece2001/bed-23085","DOIUrl":"https://doi.org/10.1115/imece2001/bed-23085","url":null,"abstract":"\u0000 Current total knee replacements have been successful in relieving the pain associated with arthritis, as well as increasing patient mobility and allowing them to partake in sports activities to a limited degree. In the elderly patient group, the ten-year survivorship has been as high as 95%. Approximately, one-third of the patients who are candidates for total knee replacement fall into the younger patient group category. In this group, where life expectancy can exceed 20 years[1], the survivorship of a TKR is limited. This becomes an important issue since one or more revision surgeries may be necessary. As a result, the chances of infection, pain associated with surgery and rehabilitation, and loss of viable bone are increased. Achieving a high degree of mobility is also a priority for this group since they tend to lead a more active lifestyle.","PeriodicalId":7238,"journal":{"name":"Advances in Bioengineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80083190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2001-11-11DOI: 10.1115/imece2001/bed-23156
L. Alexopoulos, M. Haider, F. Guilak
Articular cartilage is an aneural, avascular connective tissue that serves as the resilient load-bearing surface at the articulating ends of diarthrodial joints. A sparse single population of cells known as chondrocytes maintains the extracellular matrix (ECM) of this tissue through a balance of anabolic and catabolic activities. The mechanical environment of chondrocytes, in conjunction with other genetic and environmental factors (e.g., growth factors, cytokines), plays an important role in regulating cartilage homeostasis and, as a consequence, the health of the joint.
{"title":"An Axisymmetric Elastic Layered Half-Space Model for Micropipette Aspiration of the Chondrocyte Pericellular Matrix","authors":"L. Alexopoulos, M. Haider, F. Guilak","doi":"10.1115/imece2001/bed-23156","DOIUrl":"https://doi.org/10.1115/imece2001/bed-23156","url":null,"abstract":"\u0000 Articular cartilage is an aneural, avascular connective tissue that serves as the resilient load-bearing surface at the articulating ends of diarthrodial joints. A sparse single population of cells known as chondrocytes maintains the extracellular matrix (ECM) of this tissue through a balance of anabolic and catabolic activities. The mechanical environment of chondrocytes, in conjunction with other genetic and environmental factors (e.g., growth factors, cytokines), plays an important role in regulating cartilage homeostasis and, as a consequence, the health of the joint.","PeriodicalId":7238,"journal":{"name":"Advances in Bioengineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84502977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2001-11-11DOI: 10.1115/imece2001/bed-23055
Ning Ying, Wangdo Kim
A modified Euler angles method, dual Euler angles approach, has been proposed to describe exact joint motion. In the dual Euler angles method, joint motion is considered as three successive screw motions with respect to the axes of the moving segment coordinate system and the screw motion displacements are represented by dual angles accordingly. The algorithm for calculating dual Euler angles from coordinates of markers on joint segments has also been provided. In this paper, the dual Euler angles method is applied to describe the motion of ankle joint during dorsiflexion-plantarflexion. Due to the difficulty in tracking the motion of the talus segment in vivo, only the overall motion of the ankle-subtalar complex, that is, the relative motion of the foot with respect to the shank, was measured in the present study.
{"title":"Measurement of the Spatial Motion of the Ankle-Subtalar Complex","authors":"Ning Ying, Wangdo Kim","doi":"10.1115/imece2001/bed-23055","DOIUrl":"https://doi.org/10.1115/imece2001/bed-23055","url":null,"abstract":"\u0000 A modified Euler angles method, dual Euler angles approach, has been proposed to describe exact joint motion. In the dual Euler angles method, joint motion is considered as three successive screw motions with respect to the axes of the moving segment coordinate system and the screw motion displacements are represented by dual angles accordingly. The algorithm for calculating dual Euler angles from coordinates of markers on joint segments has also been provided. In this paper, the dual Euler angles method is applied to describe the motion of ankle joint during dorsiflexion-plantarflexion. Due to the difficulty in tracking the motion of the talus segment in vivo, only the overall motion of the ankle-subtalar complex, that is, the relative motion of the foot with respect to the shank, was measured in the present study.","PeriodicalId":7238,"journal":{"name":"Advances in Bioengineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84049019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2001-11-11DOI: 10.1115/imece2001/bed-23048
G. Danieli, D. Mundo, V. Sciarra
The paper presents an application of Burmester’s circular theory to the determination of the optimal mechanism used to reproduce the motion of the tibia with respect to the femur. The research takes its start from the idea of studying an external fixator to guide the motion of a tibia in a way physically compatible to the actual patient’s anatomy, in order to firmly guide the two bones after, for instance, joint reconstructive surgery, while avoiding any contact between the articular surfaces. The physiological data were determined in researches presented in other papers. However, in the initial research phases the idea was to determine the best position of an existing four-bar link, produced for an orthopaedic tutor, without any attempt at synthesising an ad hoc one. The idea of using Burmester’s theory in this operation was in reality an old one, but previous attempts were not successful. Naturally, the required four-bar link had also to be small in order to fit on the external fixator. The results of the research are extremely satisfactory, since it was possible to determine a mechanism which allows relative motion with errors in the order of fractions of millimetres, when the imposed motion had to keep the two bones separated by a minimum of one millimetre. As a consequence the two bones will never go in compression, while a gentle pulling of the ligaments will always be present. Using the approach, typical four-bar links for different human typologies were also determined.
{"title":"Use of Burmester’s Circular Theory in the Determination of the Optimal Four-Bar Link Reproducing Actual Tibia-Femur Relative Motion","authors":"G. Danieli, D. Mundo, V. Sciarra","doi":"10.1115/imece2001/bed-23048","DOIUrl":"https://doi.org/10.1115/imece2001/bed-23048","url":null,"abstract":"\u0000 The paper presents an application of Burmester’s circular theory to the determination of the optimal mechanism used to reproduce the motion of the tibia with respect to the femur. The research takes its start from the idea of studying an external fixator to guide the motion of a tibia in a way physically compatible to the actual patient’s anatomy, in order to firmly guide the two bones after, for instance, joint reconstructive surgery, while avoiding any contact between the articular surfaces. The physiological data were determined in researches presented in other papers.\u0000 However, in the initial research phases the idea was to determine the best position of an existing four-bar link, produced for an orthopaedic tutor, without any attempt at synthesising an ad hoc one. The idea of using Burmester’s theory in this operation was in reality an old one, but previous attempts were not successful.\u0000 Naturally, the required four-bar link had also to be small in order to fit on the external fixator. The results of the research are extremely satisfactory, since it was possible to determine a mechanism which allows relative motion with errors in the order of fractions of millimetres, when the imposed motion had to keep the two bones separated by a minimum of one millimetre. As a consequence the two bones will never go in compression, while a gentle pulling of the ligaments will always be present.\u0000 Using the approach, typical four-bar links for different human typologies were also determined.","PeriodicalId":7238,"journal":{"name":"Advances in Bioengineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77837402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2001-11-11DOI: 10.1115/imece2001/bed-23117
G. Holzapfel, T. Gasser
A reliable constitutive model of arterial walls is an essential prerequisite to (i) understand the functions of diseased and non-diseased arteries, to (ii) optimize the design of arterial prostheses, and to (iii) improve diagnostics and therapeutical procedures that are based on mechanical treatments, such as percutaneous transluminal angioplasty (PTA) [1] or bypass surgery. PTA is the most frequent therapeutical intervention worldwide [2] to reduce the severity of atherosclerotic stenoses. It is of great and steadily growing medical, economical and scientific interest [3].
{"title":"A Constitutive Framework for the Inelastic Mechanical Behavior of Arteries","authors":"G. Holzapfel, T. Gasser","doi":"10.1115/imece2001/bed-23117","DOIUrl":"https://doi.org/10.1115/imece2001/bed-23117","url":null,"abstract":"\u0000 A reliable constitutive model of arterial walls is an essential prerequisite to (i) understand the functions of diseased and non-diseased arteries, to (ii) optimize the design of arterial prostheses, and to (iii) improve diagnostics and therapeutical procedures that are based on mechanical treatments, such as percutaneous transluminal angioplasty (PTA) [1] or bypass surgery. PTA is the most frequent therapeutical intervention worldwide [2] to reduce the severity of atherosclerotic stenoses. It is of great and steadily growing medical, economical and scientific interest [3].","PeriodicalId":7238,"journal":{"name":"Advances in Bioengineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79827271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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