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Mechanical Design and Analysis for a Scanning Fiber Endoscope 扫描光纤内窥镜的机械设计与分析
Pub Date : 2001-11-11 DOI: 10.1115/imece2001/bed-23082
Christopher M. Brown, M. Fauver, P. Reinhall, E. Seibel
There is a need for smaller, more flexible, optical imaging tools for use in minimally invasive diagnostic and therapeutic procedures [1]. Towards this end, a novel technique of image acquisition has been developed based upon the controlled vibration of a waveguide and detection of light backscattered from the waveguide onto an object [2]. The anticipated result of this research is the creation of an optical scanner capable of operating at high frequency, with a large field-of-view (FOV) in a 1 mm diameter enclosure. The mechanics of this system have been explored for use in near-field scanning optical microscopy applications [3], and are now examined for use in a scanning fiber endoscope. Discussed in this report are the vibration characteristics of two possible waveguide geometries: a cylindrical and a tapered optical fiber.
在微创诊断和治疗过程中,需要更小、更灵活的光学成像工具[1]。为此,一种新的图像采集技术已经开发出来,该技术基于波导的可控振动和从波导到物体的光后向散射检测[2]。这项研究的预期结果是创造一种能够在高频率下工作的光学扫描仪,在直径1毫米的外壳中具有大视场(FOV)。该系统的机制已被探索用于近场扫描光学显微镜应用[3],现在正在研究用于扫描光纤内窥镜。本报告讨论了两种可能的波导几何形状的振动特性:圆柱形和锥形光纤。
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引用次数: 8
Design of a V-Plate-Wire Mandibular Fixation System v型钢板-金属丝下颌固定系统的设计
Pub Date : 2001-11-11 DOI: 10.1115/imece2001/bed-23078
M. Trabia, K. G. Zobotkin, Robert C. Wang
This paper presents a novel method for internal fixation of unstable mandibular fractures. The fixation method uses a three-screw V-shaped plate and a wire. Two screws are placed normal to the fracture line. The plate is first attached to one of the screws. A wire is then passed around the plate and the opposite screw and tightened to bring the two sides of the fracture together and align them. The plate is then fixed to the other side of the fracture using two additional screws. The fixation system is designed such that the plate carries most of the load. Finite element modeling of the system shows that the method is reliable, producing low stresses. The proposed method presents a simple and quick alternative to the usual plates currently used for mandibular fixation.
本文提出一种治疗不稳定下颌骨骨折的新方法。固定方法采用三螺钉v型板和一根钢丝。两颗螺钉垂直于骨折线放置。该板首先连接到其中一个螺钉上。然后用一根金属丝绕着钢板和相反的螺钉拧紧,使骨折的两侧连在一起并对齐。然后用另外两颗螺钉将钢板固定在骨折的另一侧。固定系统的设计使板承受大部分的载荷。系统的有限元建模表明,该方法可靠,产生的应力小。所提出的方法提供了一种简单而快速的替代目前用于下颌固定的常用钢板。
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引用次数: 1
A Matlab-Based Cardiac Mechanics Course: Exportable Tools for Graduate-Level Soft Tissue Biomechanics 基于matlab的心脏力学课程:研究生水平软组织生物力学的可导出工具
Pub Date : 2001-11-11 DOI: 10.1115/imece2001/bed-23021
J. Holmes
Graduate courses in finite elasticity and soft tissue biomechanics must deliver substantial theoretical content to prepare students for the complexities of soft tissue mechanics. In the laboratory students often discover that practical tasks such as calculating three-dimensional finite strain from marker data or reconstructing three-dimensional marker positions from two-dimensional views are not obvious despite mastery of the underlying theory. This course sought to replace as much didactic time as possible with hands-on MATLAB programming and simulations to illustrate basic theory and help students make the bridge to practical applications.
有限弹性和软组织生物力学的研究生课程必须提供大量的理论内容,使学生为软组织力学的复杂性做好准备。在实验室中,学生经常发现,尽管掌握了基本理论,但从标记数据计算三维有限应变或从二维视图重建三维标记位置等实际任务并不明显。本课程试图用MATLAB编程和模拟来取代尽可能多的教学时间,以说明基本理论并帮助学生建立实际应用的桥梁。
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引用次数: 0
Tangential Stress in Cortical Bone Subjected to Dynamic Axial Loading 动态轴向载荷下皮质骨的切向应力
Pub Date : 2001-11-11 DOI: 10.1115/imece2001/bed-23029
J. Choi, C. Dharan
Cortical bone is a complex hierarchical composite lamallae structure consisting, in general, of a mineral phase (calcium hydroxyapatite), an organic phase (collagen) and fluid [1]. In the analysis of bone, the liquid phase is usually neglected, an assumption that is reasonable for steady state or quasi-static loading. However, when cortical bone is loaded dynamically in the axial direction, the presence of the constrained fluid generates time-dependent stresses in the tangential direction. Since the tangential stress acts perpendicular to the weak transverse direction of the bone, it can create damage in this direction. Cyclic axial compressive loading will result in cyclic tensile loading in the tangential direction which can eventually result in fatigue damage. Such damage has actually been observed in studies conducted on heavily exercised race horses where damage was observed in the form of micro cracks oriented perpendicular to the tangential direction and whose fracture planes lie along the axial direction [2]. In this work, cortical bone is modeled as a biphasic material consisting of a permeable composite material filled with fluid. The geometry considered is that of a hollow cylinder made up of multiple concentric permeable lamellae filled with fluid (Fig. 1). When this structure is loaded axially in compression, a tensile tangential stress is developed which decays with time. The decay rate is a function of permeability and radial position. The greater the permeability, the faster the decay rate. The tangential stress peaks at the inner radius and decreases with radial position (Fig. 2). The tangential stress also peaks earlier at the inner radius. The rate of decay is slower at the outside surface where the bone is subjected to the tangential stress for a much longer time than at the inner surface (Fig. 2). This view of bone as a biphasic structure subjected to dynamic loading may provide a rationale for some of the damage modes observed in vivo in bones subjected to cyclic and impact loading.
皮质骨是一种复杂的分层复合层状结构,通常由矿物相(羟基磷灰石钙)、有机相(胶原蛋白)和液体组成[1]。在骨的分析中,液相通常被忽略,这一假设对于稳态或准静态载荷是合理的。然而,当皮质骨在轴向动态加载时,受约束流体的存在会在切向产生随时间变化的应力。由于切向应力垂直于骨的弱横向,它可以在这个方向上造成损伤。轴向循环压缩加载会导致切向循环拉伸加载,最终导致疲劳损伤。在对高强度运动赛马的研究中,这种损伤实际上已经被观察到,损伤表现为垂直于切向的微裂纹,其断裂面沿轴向分布[2]。在这项工作中,皮质骨被建模为由充满液体的可渗透复合材料组成的双相材料。所考虑的几何结构是由充满流体的多个同心渗透性薄片组成的空心圆柱体(图1)。当该结构在轴向受压时,会产生拉切向应力,该应力随时间衰减。衰减率是渗透率和径向位置的函数。渗透率越大,衰减速度越快。切向应力在内半径处达到峰值,并随着径向位置的增加而减小(图2)。切向应力在内半径处达到峰值的时间也更早。在骨受到切向应力的时间较长的情况下,骨的外表面的衰变速度比内表面慢得多(图2)。这种将骨视为受动态载荷影响的双相结构的观点,可能为在体内观察到的受循环和冲击载荷影响的骨的一些损伤模式提供了理论依据。
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引用次数: 0
Dynamic Hydrostatic Pressurization Increases Matrix Gene Expression by Chondrocytes in 3D Culture 动态静水加压增加三维培养软骨细胞基质基因表达
Pub Date : 2001-11-11 DOI: 10.1115/imece2001/bed-23147
R. Mauck, M. Soltz, G. Ateshian, C. Hung
Articular cartilage is the load-bearing substance that covers the bony surfaces of articulating bones. With its high water content and small pore size, deformation of cartilage induces a very high hydrostatic pressure within the cartilage. This hydrostatic pressure has been shown both theoretically and experimentally to support upwards of 90% of the applied load (1), and can be on the order of 6–12 MPa. Chondrocytes, the cells within cartilage respond to this pressure by altering their rates of biosynthesis. Studies utilizing radionucleotide incorporation in both explant and monolayer cultures (2–4) have shown that in general dynamic pressurization increases synthesis, while static pressurization decreases synthesis. More recently, Smith et al have shown that dynamic pressurization (10MPa, 1 Hz) of cells in monolayer culture can upregulate matrix gene expression (5,6). Further, a study in PGA constructs has shown that long term application of dynamic pressure can increase matrix deposition (7). In this study, we seek to expand on these findings by examining the response in gene expression of articular chondrocytes encapsulated in alginate, a charged, 3D hydrogel.
关节软骨是覆盖在关节骨表面的承重物质。软骨的高含水量和小孔径,使其变形在软骨内部产生非常高的静水压力。这个静水压力在理论和实验上都被证明可以支撑90%以上的载荷(1),并且可以在6-12兆帕的量级上。软骨细胞,软骨内的细胞通过改变它们的生物合成速率来应对这种压力。在外植体和单层培养中利用放射性核苷酸掺入的研究(2-4)表明,通常动态加压会增加合成,而静态加压会减少合成。最近,Smith等人发现单层培养细胞的动态加压(10MPa, 1hz)可以上调基质基因表达(5,6)。此外,一项关于PGA结构的研究表明,长期应用动压可以增加基质沉积(7)。在本研究中,我们试图通过检测海藻酸盐(一种带电的3D水凝胶)包裹的关节软骨细胞对基因表达的反应来扩展这些发现。
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引用次数: 1
Customized Resurfacing of the Knee: Design of the Shell Knee Replacement 定制膝关节表面:壳式膝关节置换术的设计
Pub Date : 2001-11-11 DOI: 10.1115/imece2001/bed-23085
Naphysah O. Duncan, P. Walker, H. Potter
Current total knee replacements have been successful in relieving the pain associated with arthritis, as well as increasing patient mobility and allowing them to partake in sports activities to a limited degree. In the elderly patient group, the ten-year survivorship has been as high as 95%. Approximately, one-third of the patients who are candidates for total knee replacement fall into the younger patient group category. In this group, where life expectancy can exceed 20 years[1], the survivorship of a TKR is limited. This becomes an important issue since one or more revision surgeries may be necessary. As a result, the chances of infection, pain associated with surgery and rehabilitation, and loss of viable bone are increased. Achieving a high degree of mobility is also a priority for this group since they tend to lead a more active lifestyle.
目前的全膝关节置换术已经成功地缓解了与关节炎相关的疼痛,增加了患者的活动能力,并允许他们在一定程度上参加体育活动。在老年患者组中,10年生存率高达95%。大约三分之一的全膝关节置换术患者属于年轻患者群体。在这一群体中,预期寿命可超过20岁,TKR的存活时间有限。这成为一个重要的问题,因为一个或多个翻修手术可能是必要的。因此,感染的机会,手术和康复相关的疼痛,以及可存活骨的丧失都增加了。对于这个群体来说,实现高度的机动性也是一个优先考虑的问题,因为他们往往过着更积极的生活方式。
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引用次数: 0
An Axisymmetric Elastic Layered Half-Space Model for Micropipette Aspiration of the Chondrocyte Pericellular Matrix 微吸管吸入软骨细胞周基质的轴对称弹性层状半空间模型
Pub Date : 2001-11-11 DOI: 10.1115/imece2001/bed-23156
L. Alexopoulos, M. Haider, F. Guilak
Articular cartilage is an aneural, avascular connective tissue that serves as the resilient load-bearing surface at the articulating ends of diarthrodial joints. A sparse single population of cells known as chondrocytes maintains the extracellular matrix (ECM) of this tissue through a balance of anabolic and catabolic activities. The mechanical environment of chondrocytes, in conjunction with other genetic and environmental factors (e.g., growth factors, cytokines), plays an important role in regulating cartilage homeostasis and, as a consequence, the health of the joint.
关节软骨是一种神经的、无血管的结缔组织,在关节末端作为弹性的承重面。软骨细胞是一种稀疏的单一细胞群,通过合成代谢和分解代谢活动的平衡来维持组织的细胞外基质(ECM)。软骨细胞的机械环境与其他遗传和环境因素(如生长因子、细胞因子)一起,在调节软骨稳态和关节健康方面起着重要作用。
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引用次数: 1
Measurement of the Spatial Motion of the Ankle-Subtalar Complex 踝-距下复合体空间运动的测量
Pub Date : 2001-11-11 DOI: 10.1115/imece2001/bed-23055
Ning Ying, Wangdo Kim
A modified Euler angles method, dual Euler angles approach, has been proposed to describe exact joint motion. In the dual Euler angles method, joint motion is considered as three successive screw motions with respect to the axes of the moving segment coordinate system and the screw motion displacements are represented by dual angles accordingly. The algorithm for calculating dual Euler angles from coordinates of markers on joint segments has also been provided. In this paper, the dual Euler angles method is applied to describe the motion of ankle joint during dorsiflexion-plantarflexion. Due to the difficulty in tracking the motion of the talus segment in vivo, only the overall motion of the ankle-subtalar complex, that is, the relative motion of the foot with respect to the shank, was measured in the present study.
提出了一种改进的欧拉角法,即对偶欧拉角法来描述关节的精确运动。在双欧拉角法中,将关节运动视为相对于运动线段坐标系轴的连续三次螺旋运动,螺旋运动位移用双角度表示。给出了由关节段上标记点坐标计算对偶欧拉角的算法。本文采用双欧拉角法描述踝关节在背屈-跖屈过程中的运动。由于难以在体内跟踪距骨节的运动,因此本研究仅测量了踝关节-距下复合体的整体运动,即足相对于小腿的相对运动。
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引用次数: 0
Use of Burmester’s Circular Theory in the Determination of the Optimal Four-Bar Link Reproducing Actual Tibia-Femur Relative Motion 利用Burmester的圆形理论确定再现胫骨-股骨实际相对运动的最佳四杆连杆
Pub Date : 2001-11-11 DOI: 10.1115/imece2001/bed-23048
G. Danieli, D. Mundo, V. Sciarra
The paper presents an application of Burmester’s circular theory to the determination of the optimal mechanism used to reproduce the motion of the tibia with respect to the femur. The research takes its start from the idea of studying an external fixator to guide the motion of a tibia in a way physically compatible to the actual patient’s anatomy, in order to firmly guide the two bones after, for instance, joint reconstructive surgery, while avoiding any contact between the articular surfaces. The physiological data were determined in researches presented in other papers. However, in the initial research phases the idea was to determine the best position of an existing four-bar link, produced for an orthopaedic tutor, without any attempt at synthesising an ad hoc one. The idea of using Burmester’s theory in this operation was in reality an old one, but previous attempts were not successful. Naturally, the required four-bar link had also to be small in order to fit on the external fixator. The results of the research are extremely satisfactory, since it was possible to determine a mechanism which allows relative motion with errors in the order of fractions of millimetres, when the imposed motion had to keep the two bones separated by a minimum of one millimetre. As a consequence the two bones will never go in compression, while a gentle pulling of the ligaments will always be present. Using the approach, typical four-bar links for different human typologies were also determined.
本文提出了一个应用Burmester的圆形理论,以确定最佳的机制,用于复制运动的胫骨相对于股骨。这项研究的出发点是研究一种外部固定架,以一种与实际患者的解剖结构物理相容的方式引导胫骨的运动,以便在关节重建手术后牢固地引导两块骨头,同时避免关节表面之间的任何接触。生理数据由其他论文的研究确定。然而,在最初的研究阶段,我们的想法是确定现有的四杆连杆的最佳位置,为骨科导师生产,没有任何尝试合成一个特别的连杆。在这次手术中使用伯梅斯特理论的想法实际上是一个古老的想法,但以前的尝试都不成功。当然,所需的四杆连杆也必须小,以适应外部固定架。研究的结果非常令人满意,因为有可能确定一种机制,当施加的运动必须使两块骨头保持至少一毫米的距离时,它允许相对运动的误差在毫米的数量级上。因此,两根骨头永远不会受压,而韧带的轻微拉扯将永远存在。使用该方法,还确定了不同人类类型的典型四杆连杆。
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引用次数: 4
A Constitutive Framework for the Inelastic Mechanical Behavior of Arteries 动脉非弹性力学行为的本构框架
Pub Date : 2001-11-11 DOI: 10.1115/imece2001/bed-23117
G. Holzapfel, T. Gasser
A reliable constitutive model of arterial walls is an essential prerequisite to (i) understand the functions of diseased and non-diseased arteries, to (ii) optimize the design of arterial prostheses, and to (iii) improve diagnostics and therapeutical procedures that are based on mechanical treatments, such as percutaneous transluminal angioplasty (PTA) [1] or bypass surgery. PTA is the most frequent therapeutical intervention worldwide [2] to reduce the severity of atherosclerotic stenoses. It is of great and steadily growing medical, economical and scientific interest [3].
可靠的动脉壁本构模型是以下方面的必要前提:(i)了解病变和非病变动脉的功能,(ii)优化动脉假体的设计,以及(iii)改进基于机械治疗的诊断和治疗程序,如经皮腔内血管成形术(PTA)[1]或搭桥手术。PTA是世界范围内最常用的治疗干预措施[2],可降低动脉粥样硬化性狭窄的严重程度。它在医学、经济和科学方面具有巨大且不断增长的价值[3]。
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引用次数: 0
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Advances in Bioengineering
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