Near Infrared Light-Triggerd on-Demand Drug Delivery From Non-Toxic Hydrogel Microbeads with Heat Transducer

2021 21st International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers) Pub Date : 2021-06-20 DOI:10.1109/Transducers50396.2021.9495711

Shuhei Takatsuka, Takeshi Kubota, Yuta Kurashina, H. Onoe

{"title":"Near Infrared Light-Triggerd on-Demand Drug Delivery From Non-Toxic Hydrogel Microbeads with Heat Transducer","authors":"Shuhei Takatsuka, Takeshi Kubota, Yuta Kurashina, H. Onoe","doi":"10.1109/Transducers50396.2021.9495711","DOIUrl":null,"url":null,"abstract":"This paper describes a near-infrared (NIR) light-triggered drug release system using alginate hydrogel microbeads. As a drug carrier, calcium alginate hydrogel microbeads encapsulating heat transducing particle (Fe304 particles) were fabricated by a centrifugal based fabrication method. The Fe304 particles instantly generate heat due to localized surface plasmon resonance when irradiated with NIR light. As a result, the calcium alginate hydrogel is thermally denatured to release a drug model. By irradiating NIR-laser to the hydrogel microbeads, we confirmed the release of fluorescent polystyrene particles (~ 10 nm) as a drug model. This result indicates that the polymer network of the calcium alginate hydrogel responded to the heat at the molecular scale, even though calcium alginate hydrogel is generally stable to heat. This NIR light-triggered drug release system using Fe3O4 particles would be an effectiveand safe platform for on-demand drug delivery.","PeriodicalId":6814,"journal":{"name":"2021 21st International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers)","volume":"39 1","pages":"1000-1003"},"PeriodicalIF":0.0000,"publicationDate":"2021-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"2021 21st International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/Transducers50396.2021.9495711","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

This paper describes a near-infrared (NIR) light-triggered drug release system using alginate hydrogel microbeads. As a drug carrier, calcium alginate hydrogel microbeads encapsulating heat transducing particle (Fe304 particles) were fabricated by a centrifugal based fabrication method. The Fe304 particles instantly generate heat due to localized surface plasmon resonance when irradiated with NIR light. As a result, the calcium alginate hydrogel is thermally denatured to release a drug model. By irradiating NIR-laser to the hydrogel microbeads, we confirmed the release of fluorescent polystyrene particles (~ 10 nm) as a drug model. This result indicates that the polymer network of the calcium alginate hydrogel responded to the heat at the molecular scale, even though calcium alginate hydrogel is generally stable to heat. This NIR light-triggered drug release system using Fe3O4 particles would be an effectiveand safe platform for on-demand drug delivery.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

带热传感器的无毒水凝胶微珠近红外光触发按需给药

介绍了一种利用海藻酸盐水凝胶微球制备的近红外(NIR)光触发药物释放系统。采用离心法制备海藻酸钙水凝胶微珠包封热传导颗粒(Fe304颗粒)作为药物载体。Fe304粒子在近红外光照射下，由于局部表面等离子体共振而瞬间产生热量。结果，海藻酸钙水凝胶被热变性释放药物模型。通过nir激光照射水凝胶微珠，我们证实了荧光聚苯乙烯颗粒(~ 10 nm)作为药物模型的释放。这一结果表明，尽管海藻酸钙水凝胶通常对热是稳定的，但海藻酸钙水凝胶的聚合物网络在分子尺度上对热有反应。这种使用Fe3O4颗粒的近红外光触发药物释放系统将是一种有效且安全的按需药物递送平台。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

2021 21st International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers)

自引率

0.00%

发文量