FORMULATION, DEVELOPMENT AND EVALUATION OF PHYTOSOMES OF SWERTIA PERENNIS

Abstract

The aim of the present study was performed, Extraction of plant material using hydroalcoholic extract, Phytochemical analysis of Swertia perennis L and Formulation, development and evaluation of phytosomes. The phytochemical screening of this investigation attested the presence of several secondary metabolites with known biological antioxidant activities. Hydroalcoholic extract of aerial parts of Swertia perennis was possessing antioxidant activity due to the presence of flavonoids constituent. Flavonoids content was expressed as milligrams equivalent of Quercetin per 100 milligrams of dry extract (mg QE/100mg). Total flavonoid contents are shown in Table 7.4. From these results, Hydro-alcoholic extract showed flavonoid compounds (1.021 mg QE/100mg). Different formulation of Phytosomes were prepared using different amount of phospholipids: cholesterol and extract and were evaluated for Drug Excipient compatibility study, Entrapment efficiency and particle size analysis, In vitro drug release study of prepared Phytosomes formulation. Entrapment efficiency is an important parameter for characterizing phytosomes. When the regression coefficient values of were compared, it was observed that ‘r’ values of Higuchi was maximum i.e. 0.964 hence indicating drug release from formulations was found to follow Higuchi release kinetics.