The Influence of Newcastle Disease Virus Major Proteins on Virulence

Guozhong Zhang, J. Xue, Xiao Li
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Abstract

The Newcastle disease virus (NDV) negative-strand RNA genome containssix genes. These genes encode nucleoprotein (NP), phosphoprotein (P),matrix protein (M), fusion protein (F), hemagglutinin-neuraminidase (HN),and RNA-dependent RNA polymerase (L) proteins. The six proteins affectthe virulence of NDV in different ways, but available information on thesix proteins is disparate and scattered across many databases and sources.A comprehensive overview of the proteins determining NDV virulence islacking. This review summarizes the virulence of NDV as a complex traitdetermined by these six different proteins.
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新城疫病毒主要蛋白对毒力的影响
新城疫病毒(NDV)负链RNA基因组包含6个基因。这些基因编码核蛋白(NP)、磷酸化蛋白(P)、基质蛋白(M)、融合蛋白(F)、血凝素-神经氨酸酶(HN)和RNA依赖性RNA聚合酶(L)蛋白。这六种蛋白质以不同的方式影响NDV的毒力,但关于这六种蛋白质的现有信息是完全不同的,分散在许多数据库和来源中。决定NDV毒力丧失的蛋白质的全面概述。这篇综述总结了NDV的毒力是由这六种不同的蛋白质决定的复杂性状。
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