Effect of Methanol Extract from Fruit Body of Mycoleptodonoides aitchisonii on Acute and Chronic Inflammation Models

Abstract

We have been investigating biological activities of components of natural foods. In this study, we found an antiinflammatory effect of edible mushroom, Micoleptodonoides aitchisonii (bunaharitake: Japanese name), on oral administration in mouse and rat acute and chronic inflammation models. M. aitchisonii extract significantly suppressed hind-paw edema induced by carrageenin. Furthermore, the extract not only inhibited the hind-paw edema induced by various acute phlogists such as histamine, serotonin, bradikinin, prostaglandin E1, but also suppressed the increase of vascular permeability induced by acetic acid, indicating that it primarily acts at the exudative stage of inflammation.M. aitchisonii extract inhibited both the proliferation of granulation tissue tested by a cotton pellet method and a development of adjuvant arthritis in rats, demonstrating that the extract might be effective against chronic inflammation.