A comparison of effects of enteral nutrition by endoscopic jejunal feeding tube placement versus total parenteral nutrition on patients with acute pancreatitis

Abstract

Objective To compare the effects of enteral nutrition (EN) by endoscopic jejunal feeding tube placement and total parenteral nutrition (TPN) on patients with acute pancreatitis. Methods A total of 60 patient with acute pancreatitis treated in Central Theater Air Force Hospital from March 2012 to December 2019 were enrolled, and they were divided into control group and observation group by random number table method, with 30 cases in each group. Control group received the TPN, while the observation group received the EN by endoscopic jejunal feeding tube placement. Then, the nutrition level, including serum albumin (ALB), prealbumin (PA), rehabilitation quality (ApacheⅡ), blood amylase level, C-reactive protein (CRP), clinical efficacy and complications were compared between the two groups. Results The ALB and PA levels of the observation group were higher than those of the control group on 14 d after treatment (P<0.05). The Apache Ⅱ scores of the observation group were lower than those of the control group on 7 and 14 d after treatment (P<0.05). The blood amylase level and CRP in the observation group was lower than that in the control group on 14 d after treatment (P<0.05). The total clinical efficacy rate of the observation group was 86.67% (26/30), higher than the 63.33% (19/30) of the control group (P<0.05). The incidence of the complications in the observation group was 13.33% (4/30), lower than the 36.67% (11/30) in the control group (P<0.05). Conclusions EN by endoscopic jejunal feeding tube placement can effectively ameliorate the nutritional level, improve quality of rehabilitation, reduce incidence of complications of patients with acute pancreatitis. Key words: Jejunal feeding tube; Acute pancreatitis; Rehabilitation quality; Complications