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Clinical effects of combination of edaravone, clopidogrel and butylphthalide injection on acute progressive cerebral infarction 依达拉奉、氯吡格雷、丁苯酞联合治疗急性进展性脑梗死的临床观察
Pub Date : 2020-03-10 DOI: 10.3760/CMA.J.ISSN.1674-4756.2020.05.034
X. Zhuang, Shuyan Jiang
Objective To analyze the clinical effects of combination of edaravone, clopidogrel and butylphthalide injection in the treatment of acute progressive cerebral infarction. Methods Seventy-eight patients with acute progressive cerebral infarction treated in Shouguang People’s Hospital from August 2018 to July 2019 were selected and divided into two groups, by random number table method. In the control group, 39 patients were treated with clopidogrel tablets and butylphthalide injection; while 39 patients in the observation group were treated with edaravone based on the treatment of control group. The therapeutic effects, neurological function, daily activities ability were compared between the two groups after treatment; and changes of neuron-specific enolase (NES), S-100β protein, interleukin-1, (IL-1) interleukin-2 (IL-2), interleukin-6(IL-6) were analyzed between the two groups. The incidence of adverse reactions of the two groups were observed and recorded. Results After treatment, the American National Institute of Health stroke scale (NIHSS) scores of the observation group were significantly lower than those of the control group, and the Barthel index of the observation group was significantly higher than that of the control group (P 0.05). Conclusions Combined treatment of edaravone, clopidogrel and butylphthalide in jection in patients with acute progressive cerebral infarction can improve the daily activities of patients, reduce nerve damage, and regulate levels of serum S-100β protein, NSE, IL-1, IL-2, IL-6 and other indicators, which has a good application effect. Key words: Edaravone; Butylphthalide; Clopidogrel; Acute cerebral infarction
目的分析依达拉奉、氯吡格雷、丁苯酞注射液联合治疗急性进展性脑梗死的临床疗效。方法选择2018年8月至2019年7月在寿光市人民医院住院治疗的急性进展性脑梗死患者78例,采用随机数字表法分为两组。对照组39例患者采用氯吡格雷片联合丁苯酞注射液治疗;观察组39例患者在对照组治疗的基础上加用依达拉奉治疗。比较两组治疗后的疗效、神经功能、日常活动能力;分析两组患者神经元特异性烯醇化酶(NES)、S-100β蛋白、白细胞介素-1、白细胞介素-2 (IL-2)、白细胞介素-6(IL-6)的变化。观察并记录两组患者的不良反应发生情况。结果治疗后,观察组患者美国国立卫生研究院卒中量表(NIHSS)评分显著低于对照组,Barthel指数显著高于对照组(P < 0.05)。结论依达拉芬、氯吡格雷、丁苯酞联合注射治疗急性进展性脑梗死患者,可改善患者日常活动能力,减轻神经损伤,调节血清S-100β蛋白、NSE、IL-1、IL-2、IL-6等指标水平,应用效果良好。关键词:依达拉奉;Butylphthalide;氯吡格雷;急性脑梗死
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引用次数: 0
Effects of selenium yeast combined with levothyroxine sodium on Hashimoto thyroiditis complicated by hypothyroidism 酵母硒联合左旋甲状腺素钠治疗桥本甲状腺炎合并甲状腺功能减退的疗效观察
Pub Date : 2020-03-10 DOI: 10.3760/CMA.J.ISSN.1674-4756.2020.05.032
Z. Qu, Tingting Li, Hao-Jie Guan, Jing Huo, Yu Chen
Objective To investigate the therapeutic effects of selenium yeast combined with levothyroxine sodium on Hashimoto thyroiditis patients with hypothyroidism. Methods The clinical data from 85 patients with Hashimoto thyroiditis and hypothyroidism admitted to Dezhou People’s Hospital from February 2018 to March 2019 were retrospectively analyzed. According to the drug treatment plans, patients were divided into the control group (42 cases treated with levothyroxine sodium) and observation group (43 cases treated with selenium yeast and levothyroxine sodium). Both groups were treated continuously for 90 d, and the clinical effects of the two groups were observed. The changes of thyroid function index, thyroid peroxidase antibody and thyroglobulin antibody of the two groups before and after treatment were compared. And the adverse reactions of the two groups were recorded. Results The total effective rate of the observation group (93.02%, 40/43) was higher than that of the control group (76.19%, 32/42), P 0.05). Conclusions Selenium yeast combined with levothyroxine sodium can effectively improve thyroid function, reduce thyroid antibodies and effectively control the incidence of adverse reactions in Hashimoto thyroiditis patients with hypothyroidism. Key words: Hashimoto thyroiditis; Hypothyroidism; Selenium yeast; Levothyroxine sodium
目的探讨酵母硒联合左旋甲状腺素钠治疗桥本甲状腺炎合并甲状腺功能减退的疗效。方法回顾性分析2018年2月至2019年3月德州市人民医院收治的85例桥本甲状腺炎合并甲状腺功能减退患者的临床资料。根据药物治疗方案将患者分为对照组(42例左甲状腺素钠治疗)和观察组(43例酵母硒+左甲状腺素钠治疗)。两组均连续治疗90 d,观察两组患者的临床疗效。比较两组患者治疗前后甲状腺功能指数、甲状腺过氧化物酶抗体、甲状腺球蛋白抗体的变化。并记录两组患者的不良反应。结果观察组总有效率(93.02%,40/43)高于对照组(76.19%,32/42),P < 0.05。结论酵母硒联合左旋甲状腺素钠可有效改善桥本甲状腺炎合并甲状腺功能减退患者的甲状腺功能,降低甲状腺抗体,有效控制不良反应的发生。关键词:桥本甲状腺炎;甲状腺功能减退;硒酵母;左旋甲状腺素钠
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引用次数: 0
Clinical value of monitoring the spiral artery blood flow in patients with early threatened abortion by color Doppler ultrasound 彩色多普勒超声监测早期先兆流产患者螺旋动脉血流的临床价值
Pub Date : 2020-03-10 DOI: 10.3760/CMA.J.ISSN.1674-4756.2020.05.025
Shufan Cui
Objective To investigate the clinical value of color Doppler ultrasonography in monitoring the uterine spiral artery blood flow in patients with early threatened abortion. Methods A total of 360 women with threatened abortion in the early 5-8 weeks of pregnancy treated in Taihang Hospital from June 2017 to June 2019 were selected as the study group. And another 100 healthy women with early pregnancy in the same period were selected as control group. All the pregnant women were examined by abdominal color Doppler ultrasound. The index of uterine spiral artery blood flow resistance indexes, including pulsation index, peak systolic velocity and end-diastolic velocity, were measured and compared. Results ①There was no significant difference in comparison on peak systolic velocity between the study group and control group, which was (44.89±2.45)cm/s vs. (44.35±3.18)cm/s (t=1.573, P=0.058). The end-diastolic velocity of the study group was (7.45±1.26)cm/s, lower than the (9.31±1.15)cm/s of the control group, and the resistance index (2.67±0.42) and pulse index (0.91±0.15) were higher than those of the control group (1.75±0.28, 0.72±0.09), t=14.006, 25.775, 15.861, all P<0.01. ②There was no significant difference in peak systolic velocity between successful and unsuccessful foetus protectors, (44.34±3.84)cm/s vs. (44.82±2.65)cm/s, t=0.812, P=0.209. The end-diastolic velocity of successful foetus protectors was (9.06±1.42) cm/s, higher than the (7.06±1.33) cm/s of the unsuccessful foetus protectors, while the resistance index (1.99±0.35) and the pulse index (0.82±0.19) were lower than those of the unsuccessful foetus protectors (2.98±0.41, 0.91±0.13), t=6.947, 11.728, 3.102, all P<0.01. ③There were no statistically significant differences in systolic peak and end-diastolic velocities between the successful foetus survivors in the study group and in the control group (t=0.423, 1.804, P=0.336, 0.056), while the resistance index (1.99±0.35) and pulse index (0.82±0.19) were higher than those in the control group (1.75±0.28, 0.72±0.09), t=7.085, 7.291, both P<0.01. ④The systolic peak velocity of women with miscarriage in the study group was (44.82±2.65)cm/s, which was not significant different from the (44.18±3.15)cm/s in the control group (t=1.006, P=0.158). While the end-diastolic velocity in with miscarriage in the study group was (7.06±1.33)cm/s, lower than the (9.31±1.15)cm/s in the control group (t=7.494, P<0.01). And women with miscarriage in the study group had higher resistance index (2.98±0.41) and pulse index (0.91±0.13) than the control group (1.75±0.28, 0.72±0.09), t=13.673, 6.652, both P<0.01. Conclusions Color Doppler ultrasound monitoring the uterine spiral artery blood flow indicators in patients with early threatened abortion is of great clinical significance, and plays a positive role in predicting the prognosis of patients and reasonably guiding the fetal care treatment program. Key words: Color Doppler monitoring;
目的探讨彩色多普勒超声监测早期先兆流产患者子宫螺旋动脉血流的临床价值。方法选择2017年6月~ 2019年6月在太行医院就诊的孕早期5 ~ 8周先兆流产孕妇360例为研究组。另外选取同期健康早孕妇女100名作为对照组。所有孕妇均行腹部彩色多普勒超声检查。测定并比较子宫螺旋动脉搏动指数、收缩峰值速度、舒张末期速度等血流阻力指标。结果①研究组与对照组的最大收缩期速度分别为(44.89±2.45)cm/s和(44.35±3.18)cm/s,差异无统计学意义(t=1.573, P=0.058)。研究组舒张末期速度为(7.45±1.26)cm/s,低于对照组(9.31±1.15)cm/s,阻力指数(2.67±0.42)、脉搏指数(0.91±0.15)高于对照组(1.75±0.28、0.72±0.09),t=14.006、25.775、15.861,P均<0.01。②保护剂成功组与未成功组的最大收缩速度(44.34±3.84)cm/s vs(44.82±2.65)cm/s,差异无统计学意义,t=0.812, P=0.209。保胎成功组舒张末期流速为(9.06±1.42)cm/s,高于不成功组(7.06±1.33)cm/s,阻力指数(1.99±0.35)、脉搏指数(0.82±0.19)低于不成功组(2.98±0.41、0.91±0.13),t=6.947、11.728、3.102,P均<0.01。③研究组存活胎儿的收缩压峰值和舒张末期速度与对照组比较差异无统计学意义(t=0.423, 1.804, P=0.336, 0.056),而阻力指数(1.99±0.35)和脉搏指数(0.82±0.19)高于对照组(1.75±0.28,0.72±0.09),t=7.085, 7.291, P均<0.01。④研究组流产妇女的收缩峰值流速为(44.82±2.65)cm/s,与对照组的(44.18±3.15)cm/s差异无统计学意义(t=1.006, P=0.158)。研究组合并流产时舒张末流速为(7.06±1.33)cm/s,低于对照组(9.31±1.15)cm/s (t=7.494, P<0.01)。研究组流产妇女阻力指数(2.98±0.41)、脉搏指数(0.91±0.13)高于对照组(1.75±0.28、0.72±0.09),t=13.673、6.652,P均<0.01。结论彩色多普勒超声监测早期先兆流产患者子宫螺旋动脉血流指标具有重要的临床意义,对预测患者预后、合理指导胎儿护理治疗方案具有积极作用。关键词:彩色多普勒监测;早期先兆流产;子宫螺旋动脉血流指数;预测;胎儿保护治疗
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引用次数: 0
Expression and gene isoforms of HLA-B27 in ankylosing spondylitis patients 强直性脊柱炎患者HLA-B27的表达及基因异型
Pub Date : 2020-03-10 DOI: 10.3760/CMA.J.ISSN.1674-4756.2020.05.004
B. Luo
Objective To analyze the expression and gene isoforms of HLA-B27 in patients with ankylosing spondiylitis (AS). Methods Forty-seven AS patients treated in Central People’s Hospital of Huizhou from January to December of 2018 were selected as observation group, and 47 persons who underwent physical examination in the same period were selected as control group. The expression of HLA-B27 of the two groups were determined by flow cytometry, and gene isoforms of HLA-B27 in positive patients were detected by fluorescence quantitative polymerase chain reaction. The examination results of the two groups were analyzed. Results The positive rate of HLA-B27 of the observation group was 91.49% (43/47), higher than the 8.51% (4/47) of the control group (P 0.05). HLA-B2706 and HLA-B2709 were predominant types of gene isoform in the control group, while HLA-B2704 and HLA-B2705 were main gene isoforms in the observation group. The proportion of patients with HLA-B2704 or HLA-B2705 in the observation group was bigger than that in the control group, but the proportion of patients with HLA-B2706 and HLA-B2709 in the observation group was less (P<0.05). Conclusions HLA-B27 positive is common in young male adults. Moreover, most of AS patients are HLA-B27 positive, with HLA-B2704 or HLA-B2705 as predominant gene isoforms, which is significantly different from healthy persons. Performing determination on gene iosforms of HLA-B27 is conductive to early diagnosis and treatment of AS in clinical. Key words: Spondylitis, ankylosing; HLA-B27; Gene isoforms; Differential diagnosis
目的分析强直性脊柱炎(AS)患者HLA-B27的表达及基因同型。方法选择2018年1 - 12月惠州市中心人民医院收治的AS患者47例为观察组,同期体格检查患者47例为对照组。流式细胞术检测两组患者HLA-B27的表达,荧光定量聚合酶链反应检测阳性患者HLA-B27基因同工型。对两组检查结果进行分析。结果观察组患者HLA-B27阳性率为91.49%(43/47),高于对照组的8.51% (4/47)(P < 0.05)。对照组以HLA-B2706和HLA-B2709基因亚型为主,观察组以HLA-B2704和HLA-B2705基因亚型为主。观察组携带HLA-B2704、b2705的患者比例高于对照组,而携带HLA-B2706、b2709的患者比例低于对照组(P<0.05)。结论HLA-B27阳性常见于年轻男性。此外,AS患者多数为HLA-B27阳性,以HLA-B2704或HLA-B2705为优势基因亚型,与健康人有显著差异。检测HLA-B27基因形态有助于临床对AS的早期诊断和治疗。关键词:脊柱炎;强直性;HLA-B27;基因亚型;鉴别诊断
{"title":"Expression and gene isoforms of HLA-B27 in ankylosing spondylitis patients","authors":"B. Luo","doi":"10.3760/CMA.J.ISSN.1674-4756.2020.05.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-4756.2020.05.004","url":null,"abstract":"Objective \u0000To analyze the expression and gene isoforms of HLA-B27 in patients with ankylosing spondiylitis (AS). \u0000 \u0000 \u0000Methods \u0000Forty-seven AS patients treated in Central People’s Hospital of Huizhou from January to December of 2018 were selected as observation group, and 47 persons who underwent physical examination in the same period were selected as control group. The expression of HLA-B27 of the two groups were determined by flow cytometry, and gene isoforms of HLA-B27 in positive patients were detected by fluorescence quantitative polymerase chain reaction. The examination results of the two groups were analyzed. \u0000 \u0000 \u0000Results \u0000The positive rate of HLA-B27 of the observation group was 91.49% (43/47), higher than the 8.51% (4/47) of the control group (P 0.05). HLA-B2706 and HLA-B2709 were predominant types of gene isoform in the control group, while HLA-B2704 and HLA-B2705 were main gene isoforms in the observation group. The proportion of patients with HLA-B2704 or HLA-B2705 in the observation group was bigger than that in the control group, but the proportion of patients with HLA-B2706 and HLA-B2709 in the observation group was less (P<0.05). \u0000 \u0000 \u0000Conclusions \u0000HLA-B27 positive is common in young male adults. Moreover, most of AS patients are HLA-B27 positive, with HLA-B2704 or HLA-B2705 as predominant gene isoforms, which is significantly different from healthy persons. Performing determination on gene iosforms of HLA-B27 is conductive to early diagnosis and treatment of AS in clinical. \u0000 \u0000 \u0000Key words: \u0000Spondylitis, ankylosing; HLA-B27; Gene isoforms; Differential diagnosis","PeriodicalId":9667,"journal":{"name":"Central Plains Medical Journal","volume":"36 3 1","pages":"12-15"},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89589107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of LC3-II protein and p53 protein in ovarian cancer tissue and their relationships with tumor development LC3-II蛋白和p53蛋白在卵巢癌组织中的表达及其与肿瘤发展的关系
Pub Date : 2020-03-10 DOI: 10.3760/CMA.J.ISSN.1674-4756.2020.05.009
Tao Bo, Suping Li, Fenghua Liu
Objective To investigate the expressions of microtubule light chain I protein 3-Ⅱ type (LC3-Ⅱ) protein and p53 protein in ovarian cancer tissues and their relationship with the development of ovarian cancer. Methods Eighty-four pathological specimens of epithelial ovarian cancer patients collected by the Pathology Department of the Fifth People’s Hospital of Jiaozuo were selected as the ovarian cancer group. And 80 tissue specimens of benign ovarian cancer patients were selected as the benign group. Western-blot method and immunohistochemical staining were used to detect the expression of LC3-Ⅱ and p53 protein. Results The positive expression rates of LC3-Ⅱ and p53 protein in ovarian cancer group were 66.67% (56/84) and 61.90% (52/84), which were significantly higher than the 26.25%(21/80) and 18.75% (15/80) in the benign group (P<0.05). In ovarian cancer tissues with lymph node metastasis, the positive expression rate of LC3-Ⅱ was 77.08% (37/56), which was higher than that in ovarian cancer tissues without lymph node metastasis (52.78%, 19/28), P<0.05. The positive expression rate of p53 protein in lymph node metastasis and low differentiation ovarian cancer was 75.00% (36/52) and 80.65% (25/52), respectively, which were higher than the 44.44% (16/52) and 50.94% (27/52) in high middle differentiation ovarian cancer without metastasis (P<0.05). Conclusions The up-regulation of LC3-Ⅱ and p53 protein in ovarian cancer tissues may be related to the occurrence and exacerbation of ovarian cancer. Key words: Ovarian neoplasms; Microtubule light chain I protein 3-Ⅱ type protein; p53 protein
目的探讨微管轻链1蛋白3-Ⅱ型(LC3-Ⅱ)蛋白和p53蛋白在卵巢癌组织中的表达及其与卵巢癌发生发展的关系。方法选择焦作市第五人民医院病理科收集的84例上皮性卵巢癌患者病理标本作为卵巢癌组。选取80例良性卵巢癌患者组织标本作为良性组。Western-blot法和免疫组织化学染色法检测LC3-Ⅱ和p53蛋白的表达。结果LC3-Ⅱ、p53蛋白在卵巢癌组的阳性表达率分别为66.67%(56/84)、61.90%(52/84),显著高于良性组的26.25%(21/80)、18.75%(15/80),差异有统计学意义(P<0.05)。在有淋巴结转移的卵巢癌组织中,LC3-Ⅱ阳性表达率为77.08%(37/56),高于无淋巴结转移的卵巢癌组织(52.78%,19/28),P<0.05。p53蛋白在淋巴结转移和低分化卵巢癌中的阳性表达率分别为75.00%(36/52)和80.65%(25/52),高于中高分化无转移卵巢癌的44.44%(16/52)和50.94% (27/52)(P<0.05)。结论LC3-Ⅱ和p53蛋白在卵巢癌组织中的表达上调可能与卵巢癌的发生和恶化有关。关键词:卵巢肿瘤;微管轻链I蛋白3-Ⅱ型蛋白;p53蛋白
{"title":"Expression of LC3-II protein and p53 protein in ovarian cancer tissue and their relationships with tumor development","authors":"Tao Bo, Suping Li, Fenghua Liu","doi":"10.3760/CMA.J.ISSN.1674-4756.2020.05.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-4756.2020.05.009","url":null,"abstract":"Objective \u0000To investigate the expressions of microtubule light chain I protein 3-Ⅱ type (LC3-Ⅱ) protein and p53 protein in ovarian cancer tissues and their relationship with the development of ovarian cancer. \u0000 \u0000 \u0000Methods \u0000Eighty-four pathological specimens of epithelial ovarian cancer patients collected by the Pathology Department of the Fifth People’s Hospital of Jiaozuo were selected as the ovarian cancer group. And 80 tissue specimens of benign ovarian cancer patients were selected as the benign group. Western-blot method and immunohistochemical staining were used to detect the expression of LC3-Ⅱ and p53 protein. \u0000 \u0000 \u0000Results \u0000The positive expression rates of LC3-Ⅱ and p53 protein in ovarian cancer group were 66.67% (56/84) and 61.90% (52/84), which were significantly higher than the 26.25%(21/80) and 18.75% (15/80) in the benign group (P<0.05). In ovarian cancer tissues with lymph node metastasis, the positive expression rate of LC3-Ⅱ was 77.08% (37/56), which was higher than that in ovarian cancer tissues without lymph node metastasis (52.78%, 19/28), P<0.05. The positive expression rate of p53 protein in lymph node metastasis and low differentiation ovarian cancer was 75.00% (36/52) and 80.65% (25/52), respectively, which were higher than the 44.44% (16/52) and 50.94% (27/52) in high middle differentiation ovarian cancer without metastasis (P<0.05). \u0000 \u0000 \u0000Conclusions \u0000The up-regulation of LC3-Ⅱ and p53 protein in ovarian cancer tissues may be related to the occurrence and exacerbation of ovarian cancer. \u0000 \u0000 \u0000Key words: \u0000Ovarian neoplasms; Microtubule light chain I protein 3-Ⅱ type protein; p53 protein","PeriodicalId":9667,"journal":{"name":"Central Plains Medical Journal","volume":"59 1","pages":"28-32"},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84576239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic effects of nerve block combined with radiofrequency ablation on trigeminal nerve pain in oral and maxillofacial region 神经阻滞联合射频消融术治疗口腔颌面三叉神经痛的疗效观察
Pub Date : 2020-03-10 DOI: 10.3760/CMA.J.ISSN.1674-4756.2020.05.013
Zihan Li, Hongpei Wang, Jian Guo, D. Lei
Objective To investigate the clinical effects of nerve block combined with radiofrequency ablation in the treatment of trigeminal pain in oral and maxillofacial region. Methods Eighty patients with trigeminal pain in oral and maxillofacial region admitted to Second Hospital of Lanzhou University from December 2016 to October 2018 were enrolled in the study. The patients were grouped according to the order of admission, of which the first 40 cases were allocated into single group and the latter 40 cases were allocated into combined group. And the single group was treated by nerve block therapy, and the combined group was treated by nerve block combined with radiofrequency surgery. The efficacy, degree of pain before and after treatment, frequency of pain, incidence of adverse reactions, and quality of life were compared between the two groups. Results The excellent and good rate of treatment was 70.00% (28/40) in the single group, and 90.00% (36/40) in the combined group; the difference in excellent and good rate was significant between the two groups (P<0.05). After treatment, the pain scores, frequency of pain onset and quality of life interference scores of the combined group were lower than those of the single group (P<0.05); moreover, the adverse reaction rate of the combined group was 5.00% (2/40), lower than the 25.00% (10/40) of the single group (P<0.05). Conclusions In the treatment of patients with oral and maxillofacial trigeminal pain, nerve block and radiofrequency surgery can effectively improve the pain symptoms, reduce the frequency and degree of pain, reduce the incidence of adverse reactions, and improve the quality of life of patients, with great long-term efficacy. Key words: Nerve block; Oral and maxillofacial; Trigeminal pain; Radiofrequency surgery
目的探讨神经阻滞联合射频消融术治疗口腔颌面三叉神经痛的临床疗效。方法选取2016年12月至2018年10月兰州大学第二医院收治的80例口腔颌面三叉神经痛患者为研究对象。患者按入院顺序分组,其中前40例为单组,后40例为联合组。单组采用神经阻滞治疗,联合组采用神经阻滞联合射频手术治疗。比较两组患者的疗效、治疗前后疼痛程度、疼痛频次、不良反应发生率及生活质量。结果单药组优良率为70.00%(28/40),联合用药组优良率为90.00% (36/40);两组优良率比较差异有统计学意义(P<0.05)。治疗后,联合治疗组疼痛评分、疼痛发作频率、生活质量干扰评分均低于单独治疗组(P<0.05);联合用药组不良反应发生率为5.00%(2/40),低于单独用药组25.00% (10/40)(P<0.05)。结论在治疗口腔颌面三叉神经痛患者时,神经阻滞联合射频手术可有效改善疼痛症状,降低疼痛频率和程度,减少不良反应的发生,提高患者的生活质量,具有很大的远期疗效。关键词:神经阻滞;口腔颌面;三叉神经疼痛;射频手术
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引用次数: 0
Comparison of effects of combined spinal and epidural anesthesia versus total intravenous anesthesia in percutaneous nephroscope lithoipsy 脊髓硬膜外联合麻醉与全静脉麻醉在经皮肾镜取石术中的效果比较
Pub Date : 2020-03-10 DOI: 10.3760/CMA.J.ISSN.1674-4756.2020.05.024
W. Dong, Xianbing Zhao, Yongqiang Guo
Objective To compare the effects of combined spinal and epidural anesthesia (CSEA) and total intravenous anesthesia (TIVA) in percutaneous nephroscope lithoipsy (PCNL). Methods Sixty patients who underwent PCNL in Xuchang Central Hospital from June 2017 to March 2018 were selected as the study objects. All the patients were randomly divided into control group and study group, with 30 cases in each group. Patients in the control group were anesthetized with TIVA, and patients in the study group were anesthetized with CSEA. Before anesthesia, at 10 minutes, 20 minutes, 30 minutes and 60 minutes after operation started, and after operation, the heart rate, blood oxygen saturation and blood pressure levels of the patients in the two groups were compared and analyzed. The occurrence of adverse reactions, such as dyspnea, delayed recovery and hypothermia, were recorded and analyzed. The recovery time, total block time and onset time of anesthesia were observed. Results The recovery time and the onset time of anesthesia in the study group were (14.90±1.90) min, (25.54±7.90)s, respectively, which were significantly shorter than the (19.43±2.89)min, (38.10±10.09)s in the control group (P 0.05). The blood pressure and heart rate of the study group were lower than those of the control group at 10 min, 20 min, 30 min and 60 min after operation started (P<0.05). The incidence of adverse reactions in the study group was 16.67%(5/30), which was significantly lower than the 50.00%(15/30) in the control group (P<0.05). Conclusions CSEA can effectively reduce the incidence of postoperative adverse reactions, and shorten onset time of anesthesia, with high safety. Key words: Anesthetics; Combined spinal and epidural anesthesia; Anesthesia, intravenous; Percutaneous nephrolithotripsy
目的比较脊髓硬膜外联合麻醉(CSEA)与全静脉麻醉(TIVA)在经皮肾镜碎石术(PCNL)中的应用效果。方法选取2017年6月至2018年3月在许昌市中心医院行PCNL的患者60例作为研究对象。所有患者随机分为对照组和研究组,每组各30例。对照组采用TIVA麻醉,研究组采用CSEA麻醉。比较分析麻醉前、手术开始后10分钟、20分钟、30分钟、60分钟及术后两组患者的心率、血氧饱和度、血压水平。记录并分析呼吸困难、恢复迟缓、体温过低等不良反应的发生情况。观察麻醉恢复时间、总阻滞时间和麻醉起效时间。结果研究组麻醉恢复时间为(14.90±1.90)min,麻醉起效时间为(25.54±7.90)s,明显短于对照组的(19.43±2.89)min,(38.10±10.09)s (P < 0.05)。研究组在手术开始后10 min、20 min、30 min、60 min血压、心率均低于对照组(P<0.05)。研究组不良反应发生率为16.67%(5/30),显著低于对照组的50.00%(15/30)(P<0.05)。结论CSEA可有效降低术后不良反应的发生率,缩短麻醉起效时间,安全性高。关键词:麻醉药;脊髓硬膜外联合麻醉;静脉麻醉;经皮nephrolithotripsy
{"title":"Comparison of effects of combined spinal and epidural anesthesia versus total intravenous anesthesia in percutaneous nephroscope lithoipsy","authors":"W. Dong, Xianbing Zhao, Yongqiang Guo","doi":"10.3760/CMA.J.ISSN.1674-4756.2020.05.024","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-4756.2020.05.024","url":null,"abstract":"Objective \u0000To compare the effects of combined spinal and epidural anesthesia (CSEA) and total intravenous anesthesia (TIVA) in percutaneous nephroscope lithoipsy (PCNL). \u0000 \u0000 \u0000Methods \u0000Sixty patients who underwent PCNL in Xuchang Central Hospital from June 2017 to March 2018 were selected as the study objects. All the patients were randomly divided into control group and study group, with 30 cases in each group. Patients in the control group were anesthetized with TIVA, and patients in the study group were anesthetized with CSEA. Before anesthesia, at 10 minutes, 20 minutes, 30 minutes and 60 minutes after operation started, and after operation, the heart rate, blood oxygen saturation and blood pressure levels of the patients in the two groups were compared and analyzed. The occurrence of adverse reactions, such as dyspnea, delayed recovery and hypothermia, were recorded and analyzed. The recovery time, total block time and onset time of anesthesia were observed. \u0000 \u0000 \u0000Results \u0000The recovery time and the onset time of anesthesia in the study group were (14.90±1.90) min, (25.54±7.90)s, respectively, which were significantly shorter than the (19.43±2.89)min, (38.10±10.09)s in the control group (P 0.05). The blood pressure and heart rate of the study group were lower than those of the control group at 10 min, 20 min, 30 min and 60 min after operation started (P<0.05). The incidence of adverse reactions in the study group was 16.67%(5/30), which was significantly lower than the 50.00%(15/30) in the control group (P<0.05). \u0000 \u0000 \u0000Conclusions \u0000CSEA can effectively reduce the incidence of postoperative adverse reactions, and shorten onset time of anesthesia, with high safety. \u0000 \u0000 \u0000Key words: \u0000Anesthetics; Combined spinal and epidural anesthesia; Anesthesia, intravenous; Percutaneous nephrolithotripsy","PeriodicalId":9667,"journal":{"name":"Central Plains Medical Journal","volume":"22 1","pages":"80-82"},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77380392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of hemabate combined with low B-Lynch suture in the treatment of refractory placenta previa postpartum hemorrhage hemabate联合低B-Lynch缝合治疗难治性产后前置胎盘出血的疗效观察
Pub Date : 2020-03-10 DOI: 10.3760/CMA.J.ISSN.1674-4756.2020.05.023
Ruiliu Li
Objective To investigate the efficacy of hemabate combined with low B-Lynch suture in the treatment of refractory placenta previa postpartum hemorrhage. Methods The clinical data from 96 patients with refractory placenta previa postpartum hemorrhage treated in Shanxi Maternal and Child Health Care Hospital from February 2017 to August 2019 were analyzed. And enrolled patients were divided into control group (48 cases) and observation group (48 cases) by their treatment methods. Patients in the control group were treated by oxytocin and interrupted figure 8 suture, and patients in the observation group were treated by hemabate and low B-Lynch suture. The curative effects, volume of bleeding and uterine volume were compared between the two groups. Results The total effective rate of treatment in the observation group was 97.92% (47/48), higher than the 83.33% (40/48) in the control group (P<0.05). The vaginal blood loss at 2 and 24 h after operation in the observation group were (60.39±12.64)ml and (31.26±6.41)ml, respectively, which were lower than the (124.43±24.72)ml and (65.68±9.27)ml in the control group (P<0.05). The uterine volumes in the observation group at 30 and 45 d after treatment were (167.53±18.29) cm3 and (103.14±15.29) cm3, respectively, which were smaller than the (208.42±23.46) cm3 and (146.19±18.37) cm3 in the control group (P<0.05). Conclusions Hemabate combined with low B-Lynch suture is effective in the treatment of refractory placenta previa postpartum hemorrhage, which can reduce postoperative bleeding and promote uterine recovery. Key words: Postpartum hemorrhage; Placenta previa; Low B-Lynch surture; Efficacy
目的探讨hemabate联合低B-Lynch缝合治疗难治性产后前置胎盘出血的疗效。方法对山西省妇幼保健院2017年2月至2019年8月收治的96例难治性产后前置胎盘出血患者的临床资料进行分析。将入组患者按治疗方法分为对照组(48例)和观察组(48例)。对照组采用催产素+断续8字形缝合,观察组采用hemabate +低B-Lynch缝合。比较两组患者的疗效、出血量及子宫体积。结果观察组治疗总有效率为97.92%(47/48),高于对照组的83.33% (40/48)(P<0.05)。观察组术后2、24 h阴道出血量分别为(60.39±12.64)ml、(31.26±6.41)ml,低于对照组(124.43±24.72)ml、(65.68±9.27)ml (P<0.05)。观察组治疗后30、45 d子宫体积分别为(167.53±18.29)cm3和(103.14±15.29)cm3,小于对照组的(208.42±23.46)cm3和(146.19±18.37)cm3 (P<0.05)。结论Hemabate联合低B-Lynch缝合治疗难治性产后前置胎盘出血效果显著,可减少术后出血,促进子宫恢复。关键词:产后出血;前置胎盘;低B-Lynch缝合;功效
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引用次数: 0
Clinical features and distribution of pathogenic microorganisms of diarrhea in 186 infants 186例婴幼儿腹泻病原微生物的临床特征及分布
Pub Date : 2020-03-10 DOI: 10.3760/CMA.J.ISSN.1674-4756.2020.05.021
Hongjun Liu, Aixiang Xie, Xiaowei Zheng, Lijing Jin, Hong-li Wang
Objective To analyze the clinical features and distribution of pathogenic microorganisms of diarrhea in 186 infants. Methods The clinical data and fecal specimens from 186 children with diarrhea admitted to Puyang Hospital of Traditional Chinese Medicine from December 2015 to December 2018 were collected. The clinical features and distribution of pathogenic microorganisms of children with diarrhea were statistically analyzed. Results The children aged≤3 years accounted for 80.11% among the 186 children with diarrhea. All children had abnormal stool properties, of which 74.73% had loose or liquid stools, 11.83% had thin paste stools and 13.44% had mucous bloody stools. A total of 60.75% children were complicated by fever, and 73.12% cases were complicated by vomiting. Moreover, 52.67% of children with diarrhea were complicated with mild dehydration, 12.37% of enrolled children with moderate dehydration and 5.91% of enrolled children with severe dehydration. And 17.74% of children had leukocyte abnormalities, and 6.45% of children had erythrocyte abnormality. Among all children with diarrhea, bacterial culture of stool samples detected 30 positive cases, with the positive rate of 16.13%; and the detection rate of diarrheogenic Escherichia coli was the highest (58.06%, 18/31). Ninety-nine cases were positive for virus detection, with the positive rate of 53.23%, of which the detection rate of rotavirus was the highest (91.92%, 91/99). The positive detection rate of virus was significantly higher than that of bacteria (P 0.05). Conclusions Diarrhea in infants is mainly characterized by changes of stool properties and clinical symptoms, such as diarrhea complicated with dehydration, fever and vomiting. And it is mainly caused by viral infection, and Rotavirus is the main pathogen causing diarrhea in infants. Key words: Infants; Diarrhea; Clinical features; Pathogenic microorganisms
目的分析186例婴幼儿腹泻的临床特点及病原微生物分布。方法收集濮阳市中医院2015年12月至2018年12月收治的186例腹泻患儿的临床资料及粪便标本。统计分析腹泻患儿的临床特点及病原微生物分布。结果186例腹泻患儿中,年龄≤3岁儿童占80.11%。所有患儿大便性质均异常,其中稀便或液体便占74.73%,稀糊状便占11.83%,粘液血性便占13.44%。60.75%患儿并发发热,73.12%患儿并发呕吐。此外,52.67%的腹泻患儿合并轻度脱水,12.37%的患儿合并中度脱水,5.91%的患儿合并重度脱水。白细胞异常占17.74%,红细胞异常占6.45%。在所有腹泻患儿中,粪便样本细菌培养检出30例阳性,阳性率为16.13%;致泻性大肠杆菌检出率最高(58.06%,18/31)。病毒检测阳性99例,阳性率为53.23%,其中轮状病毒检出率最高(91.92%,91/99)。病毒检出率显著高于细菌检出率(p0.05)。结论婴幼儿腹泻主要表现为大便性质的改变和腹泻并发脱水、发热、呕吐等临床症状。主要由病毒感染引起,轮状病毒是引起婴幼儿腹泻的主要病原体。关键词:婴幼儿;腹泻;临床特征;病原微生物
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引用次数: 0
Relationship between the levels of serum lipoprotein (α), homocysteine, uric acid and the degree of coronary stenosis in patients with coronary heart disease 冠心病患者血清脂蛋白(α)、同型半胱氨酸、尿酸水平与冠状动脉狭窄程度的关系
Pub Date : 2020-03-10 DOI: 10.3760/CMA.J.ISSN.1674-4756.2020.05.019
Zhong-qin Yan
Objective To investigate the correlations of the levels of serum lipoprotein (α) , that is LP (α), plasma homocysteine (Hcy), serum uric acid (SUA) levels with the degree of coronary artery stenosis of coronary heart disease (CHD) patients. Methods A total of 90 patients with CHD admitted to Zhoukou Hospital of Traditional Chinese Medicine from July 2018 to November 2019 were selected as the study group; and 90 healthy people who had physical examination at the same period were selected as the control group. The levels of LP (α), Hcy and SUA of both groups were detected. The results of the above-mentioned indicators were recorded in the control group and study group. The differences of the detection values of LP(α), Hcy and SUA in patients with different degrees of coronary artery stenosis were analyzed. Results The levels of LP (α), Hcy and SUA in the study group were higher than those in the control group, and the difference was statistically significant (P<0.05). Among the 90 patients with CHD in the study group, the LP (α), Hcy and SUA in the severe stenosis group were the highest levels, while the LP (α), Hcy and SUA in mild stenosis group were the lowest levels, and the difference was statistically significant (P<0.05). Conclusions The detection values of LP (α), Hcy and SUA are helpful to diagnose CHD and assess severity of stenosis in coronary artery. Key words: Coronary disease; Degree of coronary artery stenosis; Serum lipoprotein (α); Uric acid; Correlation
目的探讨冠心病(CHD)患者血清脂蛋白(α)、血浆同型半胱氨酸(Hcy)、血清尿酸(SUA)水平与冠状动脉狭窄程度的相关性。方法选择2018年7月至2019年11月周口市中医院收治的冠心病患者90例为研究组;选取同期体检的健康人群90人作为对照组。检测两组大鼠血清LP (α)、Hcy、SUA水平。记录对照组和研究组上述指标的结果。分析不同冠状动脉狭窄程度患者LP(α)、Hcy、SUA检测值的差异。结果研究组患者LP (α)、Hcy、SUA水平均高于对照组,差异有统计学意义(P<0.05)。研究组90例冠心病患者中,重度狭窄组LP (α)、Hcy、SUA水平最高,轻度狭窄组LP (α)、Hcy、SUA水平最低,差异有统计学意义(P<0.05)。结论LP (α)、Hcy、SUA的检测值有助于冠心病的诊断和冠状动脉狭窄程度的评估。关键词:冠心病;冠状动脉狭窄程度;血清脂蛋白(α);尿酸;相关
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引用次数: 0
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Central Plains Medical Journal
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