{"title":"DETERMINATION OF LIGANDS SPECIFIC TO MACROPHAGE MANNOSE RECEPTORS USING COMPUTER MODELING AND SPECTRAL METHODS","authors":"E. Kudryashova","doi":"10.37747/2312-640x-2021-19-79-82","DOIUrl":null,"url":null,"abstract":"Computer simulations have shown that concanavalin A lectin is a relevant model of macrophage mannose receptors. Optimal parameters of modification of the drug carrier β-cyclodextrin were determined: a high degree of mannosylation (it is enough to use simple mannose) - from 60%, the presence of spacers. Such molecules form a strong complex with the concanavalin receptor: Kd from 0.8 to 2.2 μM.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"40 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"http://eng.biomos.ru/conference/articles.htm","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.37747/2312-640x-2021-19-79-82","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Computer simulations have shown that concanavalin A lectin is a relevant model of macrophage mannose receptors. Optimal parameters of modification of the drug carrier β-cyclodextrin were determined: a high degree of mannosylation (it is enough to use simple mannose) - from 60%, the presence of spacers. Such molecules form a strong complex with the concanavalin receptor: Kd from 0.8 to 2.2 μM.
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