{"title":"The expression and clinical significance of fractional exhaled nitric oxide and indoleamine 2, 3 dioxygenase in children with allergic asthma","authors":"Chunlin Zhang, Jiangtao Niu, Jinlin Zhang","doi":"10.3760/CMA.J.ISSN.1674-4756.2020.03.019","DOIUrl":null,"url":null,"abstract":"Objective \nTo investigate the expression of fractional exhaled nitric oxide (FeNO) and indoleamine 2, 3 dioxygenase (IDO) in children with allergic asthma and their diagnostic values for the disease. \n \n \nMethods \nSixty children with allergic asthma hospitalized and treated in Luoyang Maternal and Child Health Hospital from 2016 to 2019 were selected as observation group, and 60 healthy children who underwent physical examination during the same time period in the hospital were selected as control group. The levels of FeNO, IDO, eosinophils and lung function of the two groups were observed, and the correlation among them was also analyzed. Then the diagnostic values of FeNO and IDO levels for allergic asthma were analyzed by receiver operating characteristics (ROC) curve. \n \n \nResults \nThe observation group has higher FeNO level and lower IDO activity than the control group (P<0.05). The forced expiratory volume in 1 second (FEV1)/ forced vital capicity (FVC) levels in the observation group were significantly lower than those in the control group (P<0.05), and the eosinophil count was significantly higher than that in the control group (P<0.05). FeNO levels were negatively correlated with FEV1/FVC in children with allergic asthma (r=-0.667, P<0.05), and positively correlated with eosinophil count (r=0.813, P<0.05). The level of IDO was positively correlated with FEV1/FVC (r=0.725, P<0.05), and negatively correlated with eosinophil count (r=-0.583, P<0.05). ROC curve analysis showed that single FeNO, single IDO and FeNO combined with IDO had certain diagnostic value for allergic asthma in children. However, FeNO combined with IDO has the highest diagnostic value for allergic asthma in children, with area under curve, sensitivity and specificity as 0.937, 83.3%, and 100%, respectively. \n \n \nConclusions \nChildren with allergic asthma have increased FeNO level and decreased IDO activity, and the combined detection of FeNO and IDO has high diagnostic value for allergic asthma in children. \n \n \nKey words: \nFractional exhaled nitric oxide; Indoleamine 2, 3 Dioxygenase; Allergic asthma; Expression level; Diagnostic value","PeriodicalId":9667,"journal":{"name":"Central Plains Medical Journal","volume":"47 1","pages":"70-73"},"PeriodicalIF":0.0000,"publicationDate":"2020-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Central Plains Medical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1674-4756.2020.03.019","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Objective
To investigate the expression of fractional exhaled nitric oxide (FeNO) and indoleamine 2, 3 dioxygenase (IDO) in children with allergic asthma and their diagnostic values for the disease.
Methods
Sixty children with allergic asthma hospitalized and treated in Luoyang Maternal and Child Health Hospital from 2016 to 2019 were selected as observation group, and 60 healthy children who underwent physical examination during the same time period in the hospital were selected as control group. The levels of FeNO, IDO, eosinophils and lung function of the two groups were observed, and the correlation among them was also analyzed. Then the diagnostic values of FeNO and IDO levels for allergic asthma were analyzed by receiver operating characteristics (ROC) curve.
Results
The observation group has higher FeNO level and lower IDO activity than the control group (P<0.05). The forced expiratory volume in 1 second (FEV1)/ forced vital capicity (FVC) levels in the observation group were significantly lower than those in the control group (P<0.05), and the eosinophil count was significantly higher than that in the control group (P<0.05). FeNO levels were negatively correlated with FEV1/FVC in children with allergic asthma (r=-0.667, P<0.05), and positively correlated with eosinophil count (r=0.813, P<0.05). The level of IDO was positively correlated with FEV1/FVC (r=0.725, P<0.05), and negatively correlated with eosinophil count (r=-0.583, P<0.05). ROC curve analysis showed that single FeNO, single IDO and FeNO combined with IDO had certain diagnostic value for allergic asthma in children. However, FeNO combined with IDO has the highest diagnostic value for allergic asthma in children, with area under curve, sensitivity and specificity as 0.937, 83.3%, and 100%, respectively.
Conclusions
Children with allergic asthma have increased FeNO level and decreased IDO activity, and the combined detection of FeNO and IDO has high diagnostic value for allergic asthma in children.
Key words:
Fractional exhaled nitric oxide; Indoleamine 2, 3 Dioxygenase; Allergic asthma; Expression level; Diagnostic value
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