Hematopoietic & mesenchymal - the two lineages of bone marrow stem cells

Abstract

Hematopoietic stem cells (HSCs), are multipotent stem cells that give rise to all the cell types of myeloid and lymphoid lineages. There are various markers that can be used to detect HSCs. Ex. CD34, CD59, Thy1, CD38, C-kit, lin etc.3 HSCs have some functional characteristics. They can renew and differentiate, can be mobilized from bone marrow to blood and reverse also. It also can undergo for programmed cell death. As stem cells, HSCs are defined by their ability to replenish all blood cell types (Multipotency) and their ability to self-renew.4 It is known that a small number of HSCs can expand to generate a very large number of daughter HSCs. This phenomenon is used in bone marrow transplantation, when a small number of HSCs reconstitute the hematopoietic system.5 This indicates that, subsequent to bone marrow transplantation, symmetrical cell divisions into two daughter HSCs must occur.