Utilization of phosphotungestic acid in the conductometric determination of loperamide hydrochloride and trimebutine antidiarrhea drugs

Abstract

Aim

Phosphotungestic acid (PTA), was used as titrant for the conductometric determination of loperamide hydrochloride (LOP.HCl) and trimebutine (TB) antidiarrhea drugs through ion-associated complex formation.

Method

The effect of the reagent concentration, temperature, molar combining ratio, and the solubility products of the formed ion-associates were studied and calculated.

Results

The suggested method was applied for the determination of loperamide hydrochloride and trimebutine in their pure form and pharmaceutical preparations with mean recovery values of 99.67 and 99.47 % for loperamide hydrochloride in pure form and in Imodium capsule, respectively, and 99.88 and 99.04 % for trimebutine in pure form and in Triton tablets, respectively. Relative standard deviation was less than 1.0%. The accuracy of the method was indicated by excellent recovery while low standard deviation supported the precision of the method. The sensitivity of the proposed method was discussed and the results were compared with the pharmacopeial methods.

Conclusion

The proposed procedure was simple, rapid, sensitive, and accurate and can be applied for the routine measurements of the cited drugs.