Age-related changes in the area of the human corpus callosum

Abstract

Objective: to carry out a comparative analysis of the area of the corpus callosum in men and women in adolescence, old age, and old age according to magnetic resonance imaging data. Material and methods. The results of magnetic resonance imaging studies of the brain of 138 patients (72 men and 66 women) were analyzed. The entire study material was divided into three groups. The first group included 44 adolescents (21 men and 23 women aged 16-21 years); the second group included 50 elderly people (27 men and 23 women aged 56-74 years); the third group included 44 seniors (24 men and 20 women aged 75-88 years). We determined the area of the corpus callosum in the sagittal projection along the midline. Results. The analysis of the results of the study revealed a tendency for the prevalence of cerebellar area parameters in boys and girls in comparison to the elderly and senile age representatives (p>0.05). There was a tendency for prevalence of cerebral body area parameters in elderly subjects over elderly ones (p>0.05). In all age groups there was a tendency for superiority of cerebral body area parameters in men compared to women (p>0.05). Conclusion. The obtained results of the in vivo comparative analysis of the area of the corpus callosum in humans in adolescence, old age and senile age extend the scientific knowledge of its age-specific features. Thus, these data can serve as a benchmark of age-related anatomical norm in various instrumental examinations, such as magnetic resonance imaging and computed tomography, and provide a foundation for further clinical research.