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Курский научно-практический вестник «Человек и его здоровье»最新文献

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Current position of chondroitin sulfate and glucosamine sulfate in the therapy of osteoarthritis 硫酸软骨素和硫酸氨基葡萄糖在骨关节炎治疗中的地位
M. Stepchenko, N. S. Meshcherina, Kristina S. Melnikova, E. M. Khardikova
Osteoarthritis is a chronic disease that causes the development of permanent disability of the patient and is a significant social and economic burden on the health care system of developed countries. It should be noted that the current variability of approaches to the treatment of osteoarthritis is due to a number of factors, including differences in etiology, severity of course, and clinical symptomatology of the disease, which must be analyzed and taken into account when choosing therapy. The modern approach to therapy of osteoarthritis includes the use of symptomatic slow-acting drugs (SYSADOA). Objective: to review the literature data on the role of SYSADOA in the therapeutic arsenal of patients with osteoarthritis. Materials and methods. Literature review and analysis was conducted by keyword using electronic resources of PubMed, MedLine databases in the period from 2010 to 2023. Results. The analysis of the studies conducted to date on the establishment, validity and feasibility of the group of symptomatic slow-acting drugs in the therapy of OA to control the progression of the disease showed the presence of very controversial and debatable provisions, which is associated with a diverse range of available glucosamine and chondroitin sulfate drugs. The greatest evidence base and efficacy are found in prescription preparations of crystalline glucosamine sulfate and chondroitin sulfate. Conclusion. The use of SYSADOA requires further study, including randomized placebo-controlled trials using modern joint imaging techniques.
骨关节炎是一种慢性疾病,可导致患者永久性残疾的发展,是发达国家卫生保健系统的重大社会和经济负担。需要指出的是,目前骨关节炎治疗方法的多变性是由多种因素造成的,包括病因、严重程度和疾病的临床症状的差异,在选择治疗方法时必须对这些因素进行分析和考虑。治疗骨关节炎的现代方法包括使用对症缓效药物(SYSADOA)。目的:回顾SYSADOA在骨关节炎治疗中的作用。材料和方法。利用PubMed、MedLine数据库2010 - 2023年的电子资源,通过关键词进行文献综述和分析。结果。对迄今为止所进行的关于症状性慢作用药物组在OA治疗中控制疾病进展的建立、有效性和可行性的研究进行的分析表明,存在非常有争议和有争议的规定,这与可用的氨基葡萄糖和硫酸软骨素药物的多样性有关。最大的证据基础和功效是发现晶体硫酸氨基葡萄糖和硫酸软骨素的处方制剂。结论。SYSADOA的使用需要进一步的研究,包括使用现代关节成像技术的随机安慰剂对照试验。
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引用次数: 0
Alliance of two pandemics: COVID-19 and diabetes mellitus 两大流行病联盟:COVID-19和糖尿病
Dmitriy V. Kovalevskiy
Objective: to study the features of the course of viral pneumonia in patients with diabetes mellitus. Materials and methods. A random sampling method was used to conduct a retrospective analysis of 300 archival medical records of inpatients with laboratory-instrumentally confirmed COVID-associated pneumonia for the period 2020-2022. Results. As a result of the study, two groups were formed - the main and control. The main group included 150 patients diagnosed with diabetes mellitus; the control group consisted of 150 patients without diabetes mellitus. The average number of bed-days spent by the main group in the hospital was 12.4 days, the control group - 10.5 days (р˂0.001). Significantly more often, the main group of patients is diagnosed with a serious condition at the time of hospitalization, as well as unilateral localization of the pathological process in the lungs. Conclusion. In patients with diabetes mellitus and pneumonia caused by a new coronavirus infection, a dependence of the volume fraction of lung tissue damage on the level of hyperglycemia was revealed. In patients with DM, anticoagulant therapy was carried out longer during inpatient treatment, combinations of several groups of antibacterial drugs were used more often, and the starting dose of glucocorticosteroids was also higher.
目的:探讨糖尿病合并病毒性肺炎的病程特点。材料和方法。采用随机抽样方法,对2020-2022年300例仪器检测确诊的新型冠状病毒相关肺炎住院患者病历进行回顾性分析。结果。研究结果形成了两组——主要组和对照组。主要组为糖尿病患者150例;对照组为无糖尿病患者150例。主组患者在医院的平均住院日为12.4天,对照组为10.5天(p < 0.001)。更常见的是,主要患者在住院时被诊断为病情严重,以及肺部病变过程的单侧局限性。结论。在糖尿病合并新型冠状病毒感染的肺炎患者中,发现肺组织损伤体积分数与高血糖水平的相关性。糖尿病患者住院期间抗凝治疗时间较长,多组抗菌药物联合使用较多,糖皮质激素起始剂量也较高。
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引用次数: 0
Peculiarities of heavy metal and arsenic trans-medium transition along the chain "soil - medicinal plant material - water etracts" 重金属和砷沿“土壤-药用植物-水提取物”链跨介质过渡的特点
N. Dyakova
Low-quality herbal raw materials and the products obtained from them are important sources of various ecotoxicants, especially heavy metals, entering the human body. Aqueous extractions of medicinal plant raw materials - decoctions and infusions - are of a particular interest in this respect - as they are the most accessible and frequently used dosage forms in medical and pharmaceutical practice and traditional medicine, being at present insufficiently studied as sources of intake of various microelements in the human body. Objective: to investigate the peculiarities of heavy metals and arsenic trans-mediated transition along the chain "soil - medicinal plant raw materials - infusions and decoctions". Materials and methods. Raw materials were harvested during the flowering period in Voronezh Biosphere Reserve. The microelement composition of the samples was studied by mass spectroscopy on an ELAN-DRC device. Results. The content of toxic microelements estimated in medicinal plant raw materials of natural phytocenosis of Voronezh region does not exceed the pharmacopoeial requirements, and their total proportion in the total mineral complex - not more than 0.011%. All made infusions and decoctions from the studied raw materials infusions and decoctions also corresponded to pharmacopoeial requirements on the content of normalized elements. The efficiency of cadmium transfer in infusions and decoctions from medicinal plant raw materials ranged from 9.02% to 55.00%, arsenic - from 26.33% to 68.46%, lead - from 1.95% to 76.15%. In the chain "soil - medicinal plant material - water extracts" normalized elements in LRS to the greatest extent migrated to the decoction of burdock root: cadmium - 74.91%, arsenic - 13.98%, lead - 6.02%. The lowest degree of transition was noted for the infusion of the studied flowers: for cadmium - 4.78%, arsenic - 0.46%, lead - 0.73%. Conclusion. The findings are of great interest and may serve both for further research and for using in medical and pharmaceutical practice.
劣质草本原料及其制品是各种生态毒物特别是重金属进入人体的重要来源。药用植物原料的水萃取——煎剂和输液——在这方面特别令人感兴趣,因为它们是医疗和制药实践以及传统医学中最容易获得和最常用的剂型,目前作为人体各种微量元素摄入来源的研究还不够充分。目的:探讨“土壤-药用植物原料-汤剂”链中重金属和砷的跨界过渡特征。材料和方法。原料在沃罗涅日生物圈保护区的花期采收。在ELAN-DRC装置上用质谱法研究了样品的微量元素组成。结果。沃罗涅日地区天然草本植物药用植物原料中有毒微量元素的含量不超过药典要求,其在总矿物质复合物中的总比例不超过0.011%。所研究原料所配制的汤剂和煎剂均符合药典对标准化元素含量的要求。药用植物浸剂和煎剂对镉、砷和铅的转移效率分别为9.02% ~ 55.00%、26.33% ~ 68.46%和1.95% ~ 76.15%。在“土壤-药用植物-水提取物”链条中,LRS中标准化元素最大程度地迁移到牛蒡根煎液中:镉- 74.91%,砷- 13.98%,铅- 6.02%。所研究的花中镉- 4.78%,砷- 0.46%,铅- 0.73%的转化程度最低。结论。这些发现具有极大的意义,可用于进一步的研究,并可用于医疗和制药实践。
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引用次数: 3
Pathogenetic and structural and functional changes in the kidneys after COVID-19 COVID-19后肾脏的病理、结构和功能改变
L. Kamyshnikova, O. Efremova, D. S. Pisankina, K. S. Gorbachevskaya, Alexander N. Pishchanskiy, M. S. Sviridova
There is now a growing evidence of the long-term effects of COVID-19, affecting almost all human systems and organs, including the kidneys. The objective of this paper was to study pathogenetic and structural and functional changes in the kidneys in patients with COVID-19 infection. Materials and methods. Articles were searched in PubMed, Medline, Google Scholar, E-library, Clinical Trial databases using the keywords "post-COVID syndrome," "renal damage (kidney disease)," "COVID-19," "SARS-CoV-2," and "glomerulonephritis" in Russian and English. Databases reporting cases of detectable renal damage following a prior coronavirus infection published by September 28, 2022 were used. This review includes literature reviews, clinical cases, and original studies reporting the confirmed cases of detectable renal damage after confirmed prior COVID-19. The sources that focus only on renal damage during the acute period of coronavirus infection have been excluded. Results. Primary viral damage is carried out through the effect on the receptors of angiotensin-converting enzyme-2 (ACE-2). No less important mechanisms of viral damage are immunological and inflammatory reactions, dysfunctions of the complement system, leading to multiple organ failure. The long-term consequences of coronavirus infection on the kidneys were manifested in a decrease in the estimated glomerular filtration rate (eGFR), an increase in creatinine levels, proteinuria, and microhematuria. Dickkopf-3 protein (uDKK-3) may become a promising marker of kidney damage. Post-COVID renal disease can occur both de novo and with a previous renal complication of COVID-19. The most common morphological variants of kidney damage were tubular lesions and various morphological variants of glomerulonephritis. Conclusion. The association of COVID-19 and kidney damage in the post-COVID period is supported by common mechanisms of pathogenesis, including direct viral damage through ACE-2, inflammatory and immune reactions of the body. These data are confirmed by detectable markers of inflammation and damage to the renal tissue, the morphological picture of necrosis, fibrosis of the renal parenchyma in patients with COVID-19 infection.
现在有越来越多的证据表明COVID-19的长期影响,影响几乎所有人体系统和器官,包括肾脏。本文的目的是研究COVID-19感染患者肾脏的病理、结构和功能变化。材料和方法。文章在PubMed、Medline、谷歌学术、电子图书馆、临床试验数据库中检索,关键词为“后冠状病毒综合征”、“肾损害(肾脏疾病)”、“COVID-19”、“SARS-CoV-2”和“肾小球肾炎”,中文和英文。研究使用了截至2022年9月28日公布的报告先前冠状病毒感染后可检测到肾损害病例的数据库。本综述包括文献综述、临床病例和报告先前确诊的COVID-19后可检测到肾损害确诊病例的原始研究。排除了冠状病毒感染急性期仅关注肾脏损害的来源。结果。主要的病毒损伤是通过对血管紧张素转换酶-2 (ACE-2)受体的影响进行的。同样重要的病毒损伤机制是免疫和炎症反应,补体系统功能障碍,导致多器官功能衰竭。冠状病毒感染对肾脏的长期影响表现为肾小球滤过率(eGFR)降低、肌酐水平升高、蛋白尿和微量血尿。Dickkopf-3蛋白(uDKK-3)可能成为一种有希望的肾脏损伤标志物。COVID-19后肾脏疾病既可以从头发生,也可以与先前的COVID-19肾脏并发症一起发生。肾损害最常见的形态变异是肾小管病变和肾小球肾炎的各种形态变异。结论。COVID-19与COVID-19后肾损害的关联得到了常见发病机制的支持,包括病毒通过ACE-2的直接损害、机体的炎症和免疫反应。这些数据得到了COVID-19感染患者肾组织炎症和损伤的可检测标志物、肾实质坏死和纤维化的形态学图像的证实。
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引用次数: 0
Immunological factors as predictors of chronic acute urticaria 免疫因素作为慢性急性荨麻疹的预测因子
S. Yudina, T. Rusanova, I. A. Ivanova, Evgenia A. Krivonkina
Objective: to conduct a comparative analysis of the level of α-defensins (HNP1-3) and cytokines (IL-8, IL-4, IL-17, TNFα) to identify predictors of chronic acute urticaria. Materials and methods. There were 57 patients under observation with acute recurrent urticaria, divided by the level of serum IgE into 3 groups: group 1 - patients with IgE levels up to 100 IU / ml, group 2 - with IgE from 100 to 500 IU / ml, group 3- with IgE over 500 IU / ml. The quantitative content of α-defensins (HNP 1-3) in blood plasma and cytokines (IL-8, IL-4, IL-17A, TNF-α), IgE in blood serum was determined by solid-phase ELISA. Rusults. The study showed that in all patients with acute urticaria there was an increase in the level of serum cytokines (IL-8, IL-17A, TNF-α) and α-defensins HNP 1-3, the most pronounced in patients of group 3 with an IgE level of more than 500 IU/ml According to the results of correlation analysis, the strongest direct correlation was found between the level of α-defensins HNP 1-3 and IL-17A. In patients of groups 2 and 3, a strong direct correlation was also found between the level of HNP 1-3 and TNFα. Conclusion. The results of the study showed that a significant increase in the level of cytokines IL-4, IL-8, IL-17A, TNF-α and α-defensins (HNP1-3) in patients with acute recurrent urticaria indicates their key role in the pathogenesis of the disease. The revealed direct correlation between the levels of α-defensins, IL-17A and TNF-α reflects the dynamics of the course of immunoinflammatory process and can be regarded as predictors of chronic acute urticaria.
目的:通过α-防御素(HNP1-3)与细胞因子(IL-8、IL-4、IL-17、tnf - α)水平的比较分析,探讨慢性急性荨麻疹的预测因素。材料和方法。将57例急性复发性荨麻疹患者按血清IgE水平分为3组:1组- IgE≥100 IU / ml, 2组- IgE≥100 ~ 500 IU / ml, 3组- IgE≥500 IU / ml,采用固相ELISA法测定血清α-防御素(HNP 1-3)及细胞因子(IL-8、IL-4、IL-17A、TNF-α)、IgE的定量含量。通过。研究发现,所有急性荨麻疹患者血清细胞因子(IL-8、IL-17A、TNF-α)及α-防御素HNP 1-3水平均有升高,其中以IgE水平大于500 IU/ml的第3组患者最为明显。根据相关分析结果,α-防御素HNP 1-3水平与IL-17A水平的直接相关性最强。在2组和3组患者中,HNP 1-3水平与TNFα之间也存在很强的直接相关性。结论。本研究结果显示,急性复发性荨麻疹患者细胞因子IL-4、IL-8、IL-17A、TNF-α和α-防御素(HNP1-3)水平显著升高,提示其在荨麻疹发病机制中起关键作用。α-防御素、IL-17A和TNF-α水平的直接相关性反映了免疫炎症过程的动态,可作为慢性急性荨麻疹的预测指标。
{"title":"Immunological factors as predictors of chronic acute urticaria","authors":"S. Yudina, T. Rusanova, I. A. Ivanova, Evgenia A. Krivonkina","doi":"10.21626/vestnik/2023-1/04","DOIUrl":"https://doi.org/10.21626/vestnik/2023-1/04","url":null,"abstract":"Objective: to conduct a comparative analysis of the level of α-defensins (HNP1-3) and cytokines (IL-8, IL-4, IL-17, TNFα) to identify predictors of chronic acute urticaria. Materials and methods. There were 57 patients under observation with acute recurrent urticaria, divided by the level of serum IgE into 3 groups: group 1 - patients with IgE levels up to 100 IU / ml, group 2 - with IgE from 100 to 500 IU / ml, group 3- with IgE over 500 IU / ml. The quantitative content of α-defensins (HNP 1-3) in blood plasma and cytokines (IL-8, IL-4, IL-17A, TNF-α), IgE in blood serum was determined by solid-phase ELISA. Rusults. The study showed that in all patients with acute urticaria there was an increase in the level of serum cytokines (IL-8, IL-17A, TNF-α) and α-defensins HNP 1-3, the most pronounced in patients of group 3 with an IgE level of more than 500 IU/ml According to the results of correlation analysis, the strongest direct correlation was found between the level of α-defensins HNP 1-3 and IL-17A. In patients of groups 2 and 3, a strong direct correlation was also found between the level of HNP 1-3 and TNFα. Conclusion. The results of the study showed that a significant increase in the level of cytokines IL-4, IL-8, IL-17A, TNF-α and α-defensins (HNP1-3) in patients with acute recurrent urticaria indicates their key role in the pathogenesis of the disease. The revealed direct correlation between the levels of α-defensins, IL-17A and TNF-α reflects the dynamics of the course of immunoinflammatory process and can be regarded as predictors of chronic acute urticaria.","PeriodicalId":24060,"journal":{"name":"Курский научно-практический вестник «Человек и его здоровье»","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80085263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Зонирование территорий исторических центров Уральских городов
Маргарита Евгеньевна Колчина, Наталья Владимировна Колчина
{"title":"Зонирование территорий исторических центров Уральских городов","authors":"Маргарита Евгеньевна Колчина, Наталья Владимировна Колчина","doi":"10.35524/978-5-98346-142-0-2023-04-30","DOIUrl":"https://doi.org/10.35524/978-5-98346-142-0-2023-04-30","url":null,"abstract":"","PeriodicalId":24060,"journal":{"name":"Курский научно-практический вестник «Человек и его здоровье»","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73642912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Features of the course of the early neonatal period in newborns from mothers who underwent COVID-19 during pregnancy (pilot prospective cohort study) 妊娠期间感染COVID-19母亲的新生儿早期病程特征(试点前瞻性队列研究)
Olga G. Betz, A. A. Kornilov, I. G. Khmelevskaya
Objective: analysis of the course of the early neonatal period in newborns from mothers who underwent COVID-19 at different gestation periods. Materials and methods. Full-term children under the age of 7 days of life born in the Regional Perinatal Center of Kursk in 2021 were under observation: group 1 - as a result of pregnancy complicated by COVID-19 infection (47 people); group 2 - control group (31 people). The main indicator of the study is the pathological nature of the course of the early neonatal period. Results. The anthropometric data at birth did not differ significantly. Transient neonatal tachypnea (19.1% in group 1 versus 9.6% in group 2, respectively), intrauterine pneumonia (19.1% in group 1 versus 3.2% in group 2, respectively; both had bilateral p values = 0.040) were detected more frequently in newborn infants. Conclusion. COVID-19 infection during pregnancy was found to be a risk factor for the development of respiratory disorders in newborns in the early neonatal period. When interpreting these data, the limitations of the study should be taken into account: the sample size, the observational nature of the study, and the methods used to measure the indicators.
目的:分析不同妊娠期感染COVID-19母亲所生新生儿的早期病程。材料和方法。观察2021年在库尔斯克地区围产期中心出生的7天以下足月儿童:1组-由于妊娠合并COVID-19感染(47人);第二组-对照组(31人)。研究的主要指标是新生儿早期病程的病理性质。结果。出生时的人体测量数据没有显著差异。新生儿短暂性呼吸急促(1组19.1%,2组9.6%),宫内肺炎(1组19.1%,2组3.2%;两者的双侧p值= 0.040)在新生儿中更为常见。结论。发现妊娠期COVID-19感染是新生儿早期发生呼吸系统疾病的危险因素。在解释这些数据时,应考虑到研究的局限性:样本量、研究的观察性质以及用于测量指标的方法。
{"title":"Features of the course of the early neonatal period in newborns from mothers who underwent COVID-19 during pregnancy (pilot prospective cohort study)","authors":"Olga G. Betz, A. A. Kornilov, I. G. Khmelevskaya","doi":"10.21626/vestnik/2023-2/02","DOIUrl":"https://doi.org/10.21626/vestnik/2023-2/02","url":null,"abstract":"Objective: analysis of the course of the early neonatal period in newborns from mothers who underwent COVID-19 at different gestation periods. Materials and methods. Full-term children under the age of 7 days of life born in the Regional Perinatal Center of Kursk in 2021 were under observation: group 1 - as a result of pregnancy complicated by COVID-19 infection (47 people); group 2 - control group (31 people). The main indicator of the study is the pathological nature of the course of the early neonatal period. Results. The anthropometric data at birth did not differ significantly. Transient neonatal tachypnea (19.1% in group 1 versus 9.6% in group 2, respectively), intrauterine pneumonia (19.1% in group 1 versus 3.2% in group 2, respectively; both had bilateral p values = 0.040) were detected more frequently in newborn infants. Conclusion. COVID-19 infection during pregnancy was found to be a risk factor for the development of respiratory disorders in newborns in the early neonatal period. When interpreting these data, the limitations of the study should be taken into account: the sample size, the observational nature of the study, and the methods used to measure the indicators.","PeriodicalId":24060,"journal":{"name":"Курский научно-практический вестник «Человек и его здоровье»","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87719558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pathophysiological aspects of dental hyperesthesia and ways to eliminate it in elderly patients after a new coronavirus infection COVID-19 新型冠状病毒感染COVID-19后老年患者牙齿感觉亢进的病理生理方面及消除方法
M. M. Shvetsov, I. Bobyntsev, A. Iordanishvili
Currently, there is no scientifically substantiated information on the occurrence of dental hyperesthesia and its causes in patients who have undergone a new coronavirus infection COVID-19. Objective: to study the occurrence of dental hyperesthesia, to analyze the causes and to find ways to eliminate it in elderly patients after a new coronavirus infection COVID-19. Material and methods. The incidence of dental hyperesthesia was studied in 175 elderly people (from 61 to 75 years old) who had a new coronavirus infection COVID-19 2-4 months ago. As a control group, 125 elderly people were examined, who had not suffered from a new COVID-19 coronavirus infection before their examination. Functional resistance of hard tissues of teeth was assessed using the index of enamel resistance test (TER-test) according to V.R. Okushko and oral hygiene using the simplified index of oral hygiene of Green-Vermillion OHI-S. Results. It has been established that in the postcovid period, dental hyperesthesia is more common in elderly patients, the cause of which is the demineralization of tooth enamel due to the deterioration of individual oral hygiene. Generally accepted oral hygiene in elderly people suffering from dental hyperesthesia contributes to the normalization of the TER-test indicators with a period of 3 to 6 months of regular dental and oral care. The additional use of remineralizing ASEPTА gel for teeth by patients during dental care made it possible to achieve high structural and functional resistance of tooth enamel during the quarter. Conclusion. In people who have undergone a new coronavirus infection COVID-19, due to the deterioration of the hygienic condition of the oral cavity, there is a decrease in the mineralization of hard tooth tissues, which is a factor in the occurrence of dental hyperesthesia and confirms the crystal chemical theory of this pathology. The additional use of remineralizing ASEPTА dental gel for individual dental and oral care makes it possible to achieve high caries resistance of tooth enamel in a shorter time.
目前,关于新型冠状病毒感染COVID-19患者发生牙齿感觉过敏及其原因尚无科学依据的信息。目的:了解老年患者新型冠状病毒感染(COVID-19)后牙齿感觉亢进的发生情况,分析其原因及消除方法。材料和方法。对175例2-4个月前感染新型冠状病毒COVID-19的老年人(61 ~ 75岁)进行了牙齿过敏的发生率研究。作为对照组,研究人员对125名未感染新型冠状病毒的老年人进行了检查。采用奥库什科(V.R. Okushko)的牙釉质阻力指数(TER-test)评估牙齿硬组织的功能阻力,采用Green-Vermillion OHI-S的简化口腔卫生指数评估口腔卫生。结果。已有研究证实,在新冠肺炎后,老年患者的牙齿感觉亢进更为常见,其原因是由于个人口腔卫生的恶化导致牙釉质脱矿。牙齿感觉亢进的老年人普遍接受的口腔卫生,通过3 ~ 6个月的定期口腔护理,有助于ter测试指标的正常化。患者在牙科护理期间额外使用牙齿再矿化ASEPTА凝胶,可以在本季度实现牙釉质的高结构和功能阻力。结论。在新型冠状病毒感染COVID-19的人群中,由于口腔卫生条件的恶化,硬牙组织的矿化减少,这是发生牙齿过敏的一个因素,证实了该病理的晶体化学理论。额外使用再矿化ASEPTА牙科凝胶进行个人牙齿和口腔护理,可以在更短的时间内实现牙釉质的高抗龋性。
{"title":"Pathophysiological aspects of dental hyperesthesia and ways to eliminate it in elderly patients after a new coronavirus infection COVID-19","authors":"M. M. Shvetsov, I. Bobyntsev, A. Iordanishvili","doi":"10.21626/vestnik/2023-2/08","DOIUrl":"https://doi.org/10.21626/vestnik/2023-2/08","url":null,"abstract":"Currently, there is no scientifically substantiated information on the occurrence of dental hyperesthesia and its causes in patients who have undergone a new coronavirus infection COVID-19. Objective: to study the occurrence of dental hyperesthesia, to analyze the causes and to find ways to eliminate it in elderly patients after a new coronavirus infection COVID-19. Material and methods. The incidence of dental hyperesthesia was studied in 175 elderly people (from 61 to 75 years old) who had a new coronavirus infection COVID-19 2-4 months ago. As a control group, 125 elderly people were examined, who had not suffered from a new COVID-19 coronavirus infection before their examination. Functional resistance of hard tissues of teeth was assessed using the index of enamel resistance test (TER-test) according to V.R. Okushko and oral hygiene using the simplified index of oral hygiene of Green-Vermillion OHI-S. Results. It has been established that in the postcovid period, dental hyperesthesia is more common in elderly patients, the cause of which is the demineralization of tooth enamel due to the deterioration of individual oral hygiene. Generally accepted oral hygiene in elderly people suffering from dental hyperesthesia contributes to the normalization of the TER-test indicators with a period of 3 to 6 months of regular dental and oral care. The additional use of remineralizing ASEPTА gel for teeth by patients during dental care made it possible to achieve high structural and functional resistance of tooth enamel during the quarter. Conclusion. In people who have undergone a new coronavirus infection COVID-19, due to the deterioration of the hygienic condition of the oral cavity, there is a decrease in the mineralization of hard tooth tissues, which is a factor in the occurrence of dental hyperesthesia and confirms the crystal chemical theory of this pathology. The additional use of remineralizing ASEPTА dental gel for individual dental and oral care makes it possible to achieve high caries resistance of tooth enamel in a shorter time.","PeriodicalId":24060,"journal":{"name":"Курский научно-практический вестник «Человек и его здоровье»","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84457968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Serum levels of 25-hydroxyvitamin D and interleukin-1β in Helicobacter pylori-infected women with postmenopausal osteoporosis 绝经后骨质疏松症幽门螺杆菌感染妇女血清25-羟基维生素D和白细胞介素-1β水平
E. A. Maylyan, Elena S. Zhadan, A. Bagriy, O. A. Trunova, E. V. Prokhorov
Dysfunction of the gastrointestinal system in Helicobacter pylori lesions significantly reduces the absorption of not only calcium (Ca), but also vitamin D and other nutrients, the intake of which is critical for bone formation. H. pylory can contribute to the formation of osteoporosis and due to the development of the inflammatory process. The inflammatory process is an important component of the pathogenesis of the above bone disease. Objective: to study of the levels of 25(OH)D and interleukin-1β in blood serum in postmenopausal OP in women with a positive test for antibodies to the Helicobacter pylori CagA antigen. Materials and methods. The study included 250 postmenopausal women, whose indicators (Me [Q1; Q3]) were 62 [56; 68] years, and the duration of the postmenopausal period is 13 [7; 20] years. In all patients, the content of 25(OH)D and interleukin-1β (IL-1β) concentrations were determined in blood serum samples. And total antibodies (IgA, IgM, IgG) to the CagA antigen of the pathogen Helicobacter pylori. Results. In the female group with postmenopausal osteoporosis, the presence of helicobacteriosis is associated with a decrease in the level of 25-hydroxyvitamin D in the blood serum by 14.8% (p=0.045). Serum IL-1β values in postmenopausal women do not depend on H. pylori infection (p>0.05). A negative correlation was found between the values of 25(OH)D and IL-1β in women with osteoporosis and a positive test for total antibodies to H. pylori (rs=-0.25; p<0.05). Conclusion. The results of the study demonstrate that the decrease in vitamin D depends on the infection with Helicobacter pylori in women with postmenopausal osteoporosis (p=0.045). The results of the studies obtained can be used in the diagnostic and treatment-and-prophylactic measures for women in the postmenopausal period.
幽门螺杆菌病变的胃肠系统功能障碍不仅会显著减少钙(Ca)的吸收,还会减少维生素D和其他营养物质的吸收,而这些营养物质的摄入对骨骼的形成至关重要。幽门螺杆菌可以促进骨质疏松症的形成,并由于炎症过程的发展。炎症过程是上述骨病发病机制的重要组成部分。目的:探讨幽门螺杆菌CagA抗原抗体阳性绝经后OP患者血清25(OH)D和白细胞介素-1β水平的变化。材料和方法。该研究包括250名绝经后妇女,其指标(Me [Q1;Q3]) 62例[56例;68]年,绝经后持续时间为13年[7;20年。在所有患者的血清样本中测定25(OH)D含量和白细胞介素-1β (IL-1β)浓度。以及针对幽门螺杆菌CagA抗原的总抗体(IgA, IgM, IgG)。结果。在绝经后骨质疏松症的女性组中,幽门杆菌病的存在与血清中25-羟基维生素D水平下降14.8%相关(p=0.045)。绝经后妇女血清IL-1β值与幽门螺杆菌感染无关(p>0.05)。骨质疏松症妇女的25(OH)D和IL-1β值与幽门螺杆菌总抗体阳性呈负相关(rs=-0.25;p < 0.05)。结论。研究结果表明,绝经后骨质疏松症妇女体内维生素D的减少与幽门螺杆菌感染有关(p=0.045)。研究结果可用于绝经后妇女的诊断、治疗和预防措施。
{"title":"Serum levels of 25-hydroxyvitamin D and interleukin-1β in Helicobacter pylori-infected women with postmenopausal osteoporosis","authors":"E. A. Maylyan, Elena S. Zhadan, A. Bagriy, O. A. Trunova, E. V. Prokhorov","doi":"10.21626/vestnik/2023-2/07","DOIUrl":"https://doi.org/10.21626/vestnik/2023-2/07","url":null,"abstract":"Dysfunction of the gastrointestinal system in Helicobacter pylori lesions significantly reduces the absorption of not only calcium (Ca), but also vitamin D and other nutrients, the intake of which is critical for bone formation. H. pylory can contribute to the formation of osteoporosis and due to the development of the inflammatory process. The inflammatory process is an important component of the pathogenesis of the above bone disease. Objective: to study of the levels of 25(OH)D and interleukin-1β in blood serum in postmenopausal OP in women with a positive test for antibodies to the Helicobacter pylori CagA antigen. Materials and methods. The study included 250 postmenopausal women, whose indicators (Me [Q1; Q3]) were 62 [56; 68] years, and the duration of the postmenopausal period is 13 [7; 20] years. In all patients, the content of 25(OH)D and interleukin-1β (IL-1β) concentrations were determined in blood serum samples. And total antibodies (IgA, IgM, IgG) to the CagA antigen of the pathogen Helicobacter pylori. Results. In the female group with postmenopausal osteoporosis, the presence of helicobacteriosis is associated with a decrease in the level of 25-hydroxyvitamin D in the blood serum by 14.8% (p=0.045). Serum IL-1β values in postmenopausal women do not depend on H. pylori infection (p>0.05). A negative correlation was found between the values of 25(OH)D and IL-1β in women with osteoporosis and a positive test for total antibodies to H. pylori (rs=-0.25; p<0.05). Conclusion. The results of the study demonstrate that the decrease in vitamin D depends on the infection with Helicobacter pylori in women with postmenopausal osteoporosis (p=0.045). The results of the studies obtained can be used in the diagnostic and treatment-and-prophylactic measures for women in the postmenopausal period.","PeriodicalId":24060,"journal":{"name":"Курский научно-практический вестник «Человек и его здоровье»","volume":"88 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80986012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of GHK peptide and its structure analogues, D-Ala-GHK AND GHK-D-Ala, on innate immunity and lipid peroxidation processes in skin wound GHK肽及其结构类似物D-Ala-GHK和GHK- d - ala对皮肤创面先天免疫和脂质过氧化过程的影响
Kamila K. Rakhmetova, I. Bobyntsev, A. Bezhin, Maksim E. Dolgintsev, A. O. Vorvul
Objective: to study the effects of the GHK peptide and its structure analogues on the mechanisms of innate immunity and lipid peroxidation in wound. Materials and methods. The experiments were performed on 70 male Wistar rats. The skin wound was modeled by applying a full-layer wound with an area of 250 mm2 on the animal's back. The peptides Gly-His-Lys (GHK), D-Ala-Gly-His-Lys (D-Ala-GHK), and Gly-His-Lys-D-Ala (GHK-D-Ala) were used in doses of 0.5 μg/kg and 1.5 μg/kg, which it was administered intradermally in doses of 0.5 μg/kg and 1.5 μg/kg in a volume of 0.1 ml for 3, 7 or 10 days. The activity of lipid peroxidation (LPO) processes in blood serum was assessed by the content of malonic dialdehyde (MDA) and acylhydroperoxides (AHP). The antioxidant mechanisms were evaluated by determining the activity of catalase and the total antioxidant activity (OAA) of blood serum. Phagocytic activity of blood neutrophils was assessed by phagocytic index (PI) and phagocytic number (PN). The activity of oxygen-dependent mechanisms in phagocytes was evaluated in a spontaneous nitroblue tetrazolium test (NBT). Results. After the administration of GHK, the tendency to PI, PN and completeness of phagocytosis prevailed, which mainly persisted with the use of peptides D-Ala-GHK and GHK-D-Ala. At the same time, the GHK-D-Ala peptide at a dose of 1.5 μg/kg had the most stable effect on phagocytic activity. The data obtained in the NBT are largely consistent with the PN indicators. At the same time, the effects of structural analogues, unlike GHK, were manifested throughout the experiment. Significantly significant changes in the activity of LPO and antioxidant mechanisms were observed with the use of all peptides. However, their dynamics, orientation and severity throughout the experiment were quite complex. Conclusion. GHK and its structural analogues, D-Ala-GHK and GHK-D-Ala, had an effect on the indicators of innate immunity and LPO in a skin wound, the severity and direction of which depends on the healing period. At the same time, the most pronounced and stable effects were observed when using GHK-D-Ala. That demonstrates the importance of protecting the tripeptide molecule from the action of carboxypeptidases.
目的:研究GHK肽及其结构类似物在创面先天免疫和脂质过氧化机制中的作用。材料和方法。实验以70只雄性Wistar大鼠为实验对象。通过在动物背部涂抹面积为250 mm2的全层伤口来模拟皮肤伤口。肽Gly-His-Lys (GHK)、D-Ala-Gly-His-Lys (D-Ala-GHK)和Gly-His-Lys- d - ala (GHK- d - ala)分别以0.5 μg/kg和1.5 μg/kg的剂量给药,以0.1 ml的体积分别给药3、7和10 d。采用丙二醛(MDA)和酰基过氧化物(AHP)含量测定血清脂质过氧化(LPO)过程的活性。通过测定过氧化氢酶活性和血清总抗氧化活性(OAA)来评价其抗氧化机制。采用吞噬指数(Phagocytic index, PI)和吞噬数(Phagocytic number, PN)评价血液中性粒细胞的吞噬活性。在自发硝基蓝四氮唑试验(NBT)中评估了吞噬细胞中氧依赖机制的活性。结果。GHK给药后,吞噬倾向于PI、PN和完全吞噬,主要与肽D-Ala-GHK和GHK- d - ala的使用有关。同时,1.5 μg/kg剂量的GHK-D-Ala肽对吞噬活性的影响最为稳定。在NBT中获得的数据与PN指标基本一致。与此同时,与GHK不同,结构类似物的作用在整个实验过程中都得到了体现。所有多肽均显著改变了LPO活性和抗氧化机制。然而,在整个实验过程中,它们的动态、方向和严重程度是相当复杂的。结论。GHK及其结构类似物D-Ala-GHK和GHK- d - ala对皮肤创面的先天免疫和LPO指标有影响,影响的严重程度和方向取决于愈合期。同时,使用GHK-D-Ala的效果最为显著和稳定。这证明了保护三肽分子免受羧基肽酶作用的重要性。
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Курский научно-практический вестник «Человек и его здоровье»
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