{"title":"Efficient synthesis of novel 3,4,5-triarylisoxazole derivatives and its antifungal activity studies","authors":"Rajesha Shetty , Syed Shafi , Yuvaraja Kuberan","doi":"10.1016/j.jopr.2013.08.006","DOIUrl":null,"url":null,"abstract":"<div><p>Novel 3,4,5-triarylisoxazole derivatives were synthesised by Suzuki reaction of 4-bromo-3, 5-diaryl isoxazoles with various boronic acid under microwave condition. The structures of the newly synthesised compounds are characterised by <sup>1</sup>H NMR, <sup>13</sup>C NMR, LC-MS and screened for their antifungal activity against <em>Aspergillus flavus</em> (NCIM No. 524), <em>Fusarium oxysporum</em> (NCIM No. 1072) and <em>Candida albicans</em> (NCIM No. 3102).</p></div>","PeriodicalId":16787,"journal":{"name":"Journal of Pharmacy Research","volume":"6 8","pages":"Pages 897-901"},"PeriodicalIF":0.0000,"publicationDate":"2013-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jopr.2013.08.006","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pharmacy Research","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0974694313003265","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
Novel 3,4,5-triarylisoxazole derivatives were synthesised by Suzuki reaction of 4-bromo-3, 5-diaryl isoxazoles with various boronic acid under microwave condition. The structures of the newly synthesised compounds are characterised by 1H NMR, 13C NMR, LC-MS and screened for their antifungal activity against Aspergillus flavus (NCIM No. 524), Fusarium oxysporum (NCIM No. 1072) and Candida albicans (NCIM No. 3102).
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