An Implementation of Gold Nanoparticles with Functionalized Surface in Biosensorics

Abstract

The dependence of calculated absorption profiles on the nanoinclusions shells characteristics allow proposing the optical control method the presence of biomolecules and their concentration in the tested bioliquid which in tiny volume being added to the prepared (in a controlled way) colloidal solution. Nanoparticles, consisting of a metallic core with dielectric nanoshells, make it possible to vary the optical resonances of such nanoparticles by varying the relative dimensions of the core and shells. For example, a monomolecular layer of a specific receptor can be attached to gold surface by a biochemical method, which is capable of selective binding with certain organic molecules (analyte) by the key-lock interactions (or the antigen-antibody interaction). Due to the subsequent binding of analyte molecules, an additional layer of biological coating will be formed. The presence of this layer changes the conditions of plasmon-polariton resonance, which will be manifested in the frequency shift of this resonance in the absorption spectra.