Therapeutic effects of thioctic acid combined with mecobalamin on peripheral neurotoxicity induced by radiochemotherapy in patients with breast cancer

Central Plains Medical Journal Pub Date : 2020-03-10 DOI:10.3760/CMA.J.ISSN.1674-4756.2020.05.027

Yaqin Chen

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Abstract

Objective To investigate the efficacy of thioctic acid combined with mecobalamin in the treatment of peripheral neurotoxicity induced by radiochemotherapy in breast cancer patients. Methods A total of 94 breast cancer patients with peripheral neurotoxic adverse reactions induced by radiochemotherapy treated in the First Affiliated Hospital of Zhengzhou University from July 2017 to July 2018 were selected as research objects. And they were divided into control group and research group by random number table method. Patients in the research group (n=47) were treated with thioctic acid and mecobalamin, and patients in the control group (n=47) were treated with vitamin B12. The therapeutic effects of the two groups were analyzed and compared. Results The overall effective rate was 87.23% (41/47) in the research group, higher than the 51.06% (24/47) in the control group, and the difference was statistically significant (χ2=5.068, P<0.05). Conclusions Thioctic acid combined with mecobalamin has better therapeutic effects than vitamin B12 in the treatment of peripheral neurotoxicity caused by radiochemotherapy in breast cancer patients. Key words: Thioctic acid; Mecobalamin; Peripheral neurotoxicity

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硫辛酸联合甲钴胺治疗乳腺癌放化疗后周围神经毒性的疗效观察

目的探讨硫辛酸联合甲钴胺治疗乳腺癌放化疗后周围神经毒性的疗效。方法选取2017年7月至2018年7月郑州大学第一附属医院收治的94例因放化疗引起周围神经毒性不良反应的乳腺癌患者作为研究对象。采用随机数字表法将其分为对照组和研究组。研究组(n=47)给予硫辛酸和甲钴胺治疗，对照组(n=47)给予维生素B12治疗。分析比较两组患者的治疗效果。结果研究组总有效率为87.23%(41/47)，高于对照组的51.06%(24/47)，差异有统计学意义(χ2=5.068, P<0.05)。结论硫辛酸联合甲钴胺治疗乳腺癌放化疗后周围神经毒性的疗效优于维生素B12。关键词:硫辛酸;Mecobalamin;外周神经毒性

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Central Plains Medical Journal

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