Cervical cytology and HPV in cervical cancer screening: Current and future perspectives

P. Bakshi, P. Agarwal, Gunjan Mangla
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Abstract

Cervical cancer remains a health burden in our country and is the 2nd most common cancer in Indian women. Effective screening can reduce the incidence as well as the morbidity and mortality of this disease. Cervical cytology and the more recent human papilloma virus (HPV) DNA test are the two main pillars of screening. Liquid based cytology has improved the cytological preparations and has shown certain advantages while advancements in molecular techniques for detection of high-risk HPV DNA/RNA has opened up new frontiers. These technological advancements have led to the changes in screening practices and paradigms and are evolving at a rapid pace. This article gives an overview of the screening modalities currently available, the technological advancements, recent updates of the screening guidelines and the future directions.
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宫颈细胞学和HPV在宫颈癌筛查中的应用:当前和未来的观点
子宫颈癌仍然是我国的健康负担,是印度妇女第二大常见癌症。有效的筛查可以降低该病的发病率以及发病率和死亡率。宫颈细胞学检查和最近的人类乳头瘤病毒(HPV) DNA测试是筛查的两个主要支柱。液体细胞学改进了细胞学制备,显示出一定的优势,而分子技术的进步为检测高危HPV DNA/RNA开辟了新的领域。这些技术进步导致了筛查做法和范例的变化,并正在迅速发展。本文概述了目前可用的筛查方式、技术进步、筛查指南的最新更新和未来的发展方向。
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