{"title":"基于FKBP12结构的药物发现: L -1,4-噻嗪-3-羧酸衍生物的设计、合成及其神经营养活性","authors":"聂爱华, 肖军海, 王莉莉, 廖国超, 刘洪英, 任珅, 李松","doi":"10.1360/ZB2006-36-6-522","DOIUrl":null,"url":null,"abstract":"以神经亲免素FKBP12为靶点, 基于FKBP12, FK506与Calcineurin的复合物晶体结构, 设计、合成和筛选能够特异地靶向FKBP12的只具有促神经生长作用的功能而不影响免疫系统的新结构神经退行性疾病治疗药物. 结果显示化合物N308作为一种促神经生长和保护的候选药物具进一步开发的前景.","PeriodicalId":49128,"journal":{"name":"Science in China. Series B, Chemistry","volume":"1 1","pages":"522-533"},"PeriodicalIF":0.0000,"publicationDate":"2006-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science in China. Series B, Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1360/ZB2006-36-6-522","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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