{"title":"Analytical Assay of Betamethasone Pharmaceutical Dosage Forms by Visible Spectrophotometry","authors":"D. R. Kumar, C. Rambabu","doi":"10.9734/bpi/nicb/v2/8205d","DOIUrl":null,"url":null,"abstract":"Two simple and reproducible methods have been developed and validated for the determination of betamethasone in pharmaceutical dosage forms by visible spectrophotometry. Method-1 is based on the formation of meisenheimer like sigma -complex by the m-dinitrobenzene with the mentioned drug in presence of alkaline medium to from a colored chromogen measured at 490nm. The Method-2 is based on reaction between MBTH and drug under study in presence of alkali to from a colored chromogen measured at 620 nm. The findings of the investigation were statistically evaluated and recovery studies supported the correctness of the proposed approaches. The methods were successfully applied to the determination of betamethasone in pharmaceutical formulations.","PeriodicalId":19155,"journal":{"name":"New Innovations in Chemistry and Biochemistry Vol. 2","volume":"30 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"New Innovations in Chemistry and Biochemistry Vol. 2","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.9734/bpi/nicb/v2/8205d","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Two simple and reproducible methods have been developed and validated for the determination of betamethasone in pharmaceutical dosage forms by visible spectrophotometry. Method-1 is based on the formation of meisenheimer like sigma -complex by the m-dinitrobenzene with the mentioned drug in presence of alkaline medium to from a colored chromogen measured at 490nm. The Method-2 is based on reaction between MBTH and drug under study in presence of alkali to from a colored chromogen measured at 620 nm. The findings of the investigation were statistically evaluated and recovery studies supported the correctness of the proposed approaches. The methods were successfully applied to the determination of betamethasone in pharmaceutical formulations.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
