The variety of immune responses to adoptogenetic balneotherapy is strictly deterministic

Abstract

Four variants of the immune responses to adaptogenic balneotherapy have been identified. It is shown that the immunotropic effect of balneotherapy on certain individuals is not effec tive enough and in some cases even unfavorable. All four variants of immune responses are virtually unmistakably predicted by a set of 20 immune and microbiota predictors. Each type of immune response is characterized by a specific vegetative, endocrine and metabolic support. In the next study the discriminant analysis revealed that the constellation 8 HRV and 5 endo crine parameters as well as gender of the patient predicts the nature of the immune response with an accuracy of 90,9%. As soon as we found out 16 metabolic parameters as the predictors which, taken together, determine the nature of the immune response with an accuracy of 95,5%. Standing on the positions of determinism, we assumed that taking into account all the recorded initial neuro-endocrine and metabolic parameters of the body would allow to predict the immune response of each patient unmistakably. Testing this hypothesis was the purpose of this study. The object of observation was 34 men and 10 women aged 24-70, who came to the Truskavets’ spa for the treatment of chronic pyelonephritis combined with cholecystitis in remission. The state of the autonomic nervous system is estimated by parameters of HRV (“CardioLab+HRV”). To assess the endocrine status we determined plasma levels of principal adaptation hormones: Cortisol, Testosterone and Triiodothyronine (ELISA with the use of analyzer “RT-2100C”). The metabolic panel amounted to: plasma lipoproteines; the plasma and daily urine levels of the electrolytes (calcium, magnesium, phosphates, chloride, sodium and potassium; nitrous metabo lites (creatinine, urea, uric acid). According to the parameters of electrolyte exchange, hormonal activity was evaluated: parathyroid, calcitonin and mineralocorticoid. Following the accepted algorithm, the forward stepwise method revealed 31 parameters as the predictors, among them: 13 HRVs, 4 endocrine, 11 metabolic as well as 2 parameters of cholekinetics and age. All types of immune response to adaptogenic balneotherapy are predicted unmistakably. The previously revealed variety of immune responses to adaptogenic balneotherapy is quite strictly conditioned by the initial state of the neuroendocrine-immune complex, microbiota, me tabolism as well as the sex and age of patients.