Cytotoxicity and Anticancer activity of Aqueous Leaf Extract of Solanum torvumon Normal Vero and Human Breast Adenocarcinoma MCF-7 Cell Line

Indo Global Journal of Pharmaceutical Sciences Pub Date : 2022-01-01 DOI:10.35652/igjps.2022.12016

S. Dhamodaran, Raja Kothandam, Saravanan Ramachandran

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引用次数: 1

Abstract

Naturalherbalproducts areformulatedwitha combinationofphytoconstituentsfrom plants which play a pivotalrole becauseof their diverse medicinal properties.Limited plants have been screened for their complete biological and pharmacological nature.In the present research workan attempt wasmade to infer the medicinal value of aqueousextract of Solanumtorvum (S.torvum)leaves. Phytochemical analysis of theaqueous extracts of S.torvumleaf in the present study ascertain the presence of flavonoids, phenols, saponins, alkaloids, coumarins, sterols, proteins and reducing sugars.Further, the potentiality of aqueous extract ofS.torvumleaveswas assessedfor its cytotoxic effecton Normal Verocell lineand anticancer activityonHumanbreast adenocarcinoma cell lineby 3-(4,5dimethylthiazole-2-yl)-2,5-diphenyl tetrazoliumbromide assay.A 24-hour incubationcell proliferation studyreducedthe cell viability of MCF-7 breast cancer cell lines.In vitro studieson cytotoxicity analysis on Vero cell line revealed thattheaqueous leaf extract of S.torvumhasno toxicityand further it was foundtobeeffectiveinthepreventionofcellproliferation by MCF-7celllines.©2022iGlobal Research and PublishingFoundation. All rights reserved.

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龙葵叶水提物与人乳腺腺癌MCF-7细胞系的细胞毒性和抗癌活性

天然草药产品是由来自植物的植物成分组合而成的，这些植物成分因其不同的药用特性而起着关键作用。有限的植物已筛选其完整的生物学和药理学性质。本研究试图推测茄叶水提物的药用价值。本研究对荆芥水提物进行了植物化学分析，确定了黄酮、酚类、皂苷、生物碱、香豆素、甾醇、蛋白质和还原糖的存在。此外，水提物的潜力。采用3-(4,5 -二甲基噻唑-2-基)-2,5-二苯基四唑溴化试验，评价其对正常细胞的细胞毒作用和对人乳腺腺癌细胞的抗癌作用。一项24小时培养细胞增殖研究降低了MCF-7乳腺癌细胞系的细胞活力。体外对Vero细胞株的细胞毒性分析表明，金针叶水提物无毒性，且对mcf -7细胞株的细胞增殖有抑制作用。©2022全球研究与出版基金会。版权所有。

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Indo Global Journal of Pharmaceutical Sciences

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