{"title":"α-Glucosidase enzyme inhibitory and free radical scavenging constituents from Premna tomentosa Linn.","authors":"Sridhar Rao Ayinampudi","doi":"10.1016/j.jopr.2013.08.013","DOIUrl":null,"url":null,"abstract":"<div><p>A bioassay-guided fractionation and chemical investigation of the whole plant of <em>Premna tomentosa</em> resulted in the isolation and characterization of premnalin (<strong>1</strong>), along with the known compounds coniferaldehyde (<strong>2</strong>), syrangaldehyde (<strong>3</strong>), acetoxy syrangaldehyde (<strong>4</strong>), lupeol (<strong>5</strong>), betulin (<strong>6</strong>), 2-(4-methoxyphenyl)-2-butanone (<strong>7</strong>), icetexatriene-1 (<strong>8</strong>), icetexatriene-2 (<strong>9</strong>). Their structures were established on the basis of extensive spectroscopic such as (IR, MS, 2D NMR) data analysis and by comparison with the spectroscopic data reported in the literature, premnalin (IC<sub>50</sub>: 12.11 μg/mL) & (SC<sub>50</sub>: 20.58 μg/mL), acetoxy syrangaldehyde (IC<sub>50</sub>: 18.41 μg/mL) & (SC<sub>50</sub>: 20.83 μg/mL) displayed potent α-glucosidase inhibition and free radical scavengers (DPPH).</p></div>","PeriodicalId":16787,"journal":{"name":"Journal of Pharmacy Research","volume":"6 8","pages":"Pages 893-896"},"PeriodicalIF":0.0000,"publicationDate":"2013-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jopr.2013.08.013","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pharmacy Research","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0974694313003332","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
A bioassay-guided fractionation and chemical investigation of the whole plant of Premna tomentosa resulted in the isolation and characterization of premnalin (1), along with the known compounds coniferaldehyde (2), syrangaldehyde (3), acetoxy syrangaldehyde (4), lupeol (5), betulin (6), 2-(4-methoxyphenyl)-2-butanone (7), icetexatriene-1 (8), icetexatriene-2 (9). Their structures were established on the basis of extensive spectroscopic such as (IR, MS, 2D NMR) data analysis and by comparison with the spectroscopic data reported in the literature, premnalin (IC50: 12.11 μg/mL) & (SC50: 20.58 μg/mL), acetoxy syrangaldehyde (IC50: 18.41 μg/mL) & (SC50: 20.83 μg/mL) displayed potent α-glucosidase inhibition and free radical scavengers (DPPH).
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
