THE USE OF HYDROLYTIC ENZYMES TO INCREASE THE EFFICIENCY OF THERAPY OF INFECTIONS ASSOCIATED WITH THE FORMATION OF BACTERIAL BIOFILM

Abstract

The successful destruction of biofilm structures and the significant decrease of non-specific bacterial adhesion to the surfaces after either Ficin or Papain treatment have been detected. The combination of enzymes with antimicrobials increased the efficacy of the latter against biofilm-embedded bacteria. Moreover, Ficin treatment lead to smoother reepithelisation, and new tissue formation exhibiting collagen structure characteristics closely reminiscent of those observed in the native tissue. Thus, both soluble and immobilized Ficin and Papain appear beneficial for the treatment of biofilm-associated infections, speeding up wound healing and microbial decontamination.