Parameter estimation of a physiological model for heat exchange during cardio-pulmonary bypass

Abstract

A model describing relations and interactions between local vessel resistances and tissue temperatures during extra-corporeal circulation (ECC) is described and developed from first principles. Unknown model parameters are estimated by means of an extended Kalman Filter from real patient data. Estimated model parameters produced good model performance in tracking patient data and produced meaningful physiological results. This approach is a necessary first step in modeling further physiological interactions in the body during hypothermic ECC.