The association of serum C-reactive protein albumin ratio with polycystic ovarian syndrome

Abstract

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder among women, characterized by various symptoms and long-term risks. Reliable diagnostic methods are needed to predict and diagnose PCOS. This study aimed to assess the serum C reactive protein/albumin ratio as a potential predictor and diagnostic tool for PCOS. Methods: This cross-sectional analytical study was conducted at the department of obstetrics and gynecology, Sir Salimullah Medical College and Mitford Hospital, Dhaka, from September 2018 to August 2019. The study included 80 participants aged 18 to 45 years, with 40 healthy subjects in group I and 40 diagnosed cases of PCOS in group II. Serum C-reactive protein and serum albumin levels were measured, and data were analyzed using descriptive statistics and Unpaired t-tests. Results: The study group had a mean age of 23.98±2.61, while the comparison group had a mean age of 23.85±2.79. Serum CRP levels were significantly higher in newly diagnosed PCOS cases (5.73±3.35) compared to non-PCOS cases (2.89±0.85) (p<0.001). The study group had a significantly higher mean CRP: albumin ratio (0.123±0.07) compared to the comparison group (0.067±0.02) (p<0.001). Conclusions: This study found that serum CRP and the CRP/albumin ratio were increased in PCOS subjects, while serum albumin levels did not differ significantly from non-PCOS subjects. These findings suggest that the serum CRP/albumin ratio could be a potential marker for predicting and diagnosing PCOS.