Synthesis and Structural Elucidation of 1, 4 Dihydropyrimido [1, 2-a] Benzimidazole

Abstract

Considering various biomedical significance & with a view of pharmacological actions of compound belong to this class, new series of N-(substituted phenyl)-2-methyl-4-(2-(6-oxo-1-phenyl-1-6-dihydro-[2-3-bipyridin]-5-yl)phenyl)-1-4-dihydro pyrimido [1, 2-a] benzimidazole-3-carboxamide ware prepared. The formation of the compound was accomplished by cyclocondensation of 2-(1, 2-dihydro-2-oxo-1-phenyl-5-(pyridin-2-yl)pyridin-3-yl) benzaldehyde and N-(substituted phenyl)-3-oxobutanamide, 2-amino-benzimidazole under acid catalyzed conditions. The structures of pyrimidobenzimidazoles were determined by MASS, IR, 1H NMR spectroscopic techniques & Elemental analysis technique.