Echocardiographic evaluation of pulmonary vascular resistance in patients with type2 diabetes mellitus concerning diabetic duration and HbAlc level and its effect on the right ventricular function

Abstract

Objective: The study aims to non-invasive assessment of PVR by echocardiography in type 2 DM and its relation to duration of DM and HbAIc level and association of PVR to RV systolic and diastolic function. Methods: This cross-sectional comparative and analytic study was conducted on 62 consisting of patients with type 2 diabetes mellitus without a history of hypertension, established coronary artery disease, and chronic obstructive pulmonary disease. All diabetic patients were studied for age, sex. BMI, HbAlc level, and duration of diabetes, and echocardiography was performed to assess PVR systolic (TAPSE.MPI) and diastolic (E/A, E/ē) function of RV. Results: The study reveals there is no significant difference in PVR RV systolic and diastolic function concerning HbAIc level and DM duration. While there is significantly higher PVR and significantly lower TAPSE and E/A in DM (p<0.05) in comparison with normal control subjects. In correlation of PVR with systolic and diastolic function of RV, there were showed a strong negative relationship between PVR and systolic function and weak positive relationship with diastolic dysfunction P-value <0.05. Conclusion: significant-high pulmonary vascular resistance in type 2 DM and inverse correlation to systolic function and linear correlation to diastolic dysfunction of the right ventricle, while there is no relation of PVR to Hb Alc level and duration DM.