Combine effect of 5-azacytidine and tgf- β in differentiation of mesenchymal stem cells towards cardiomyocytes

Abstract

Stem cells play an important role in biological research nowadays. It is a vast field holding a great potential in therapeutic approach. The purpose of the stem cell therapy is to treat injured tissues by preventing the dead cells.1 Stem cells are undifferentiated having the ability of self-renewal providing these cells in life throughout.2 Mesenchymal stem Cells (MSCs) are multipotent stem cells that reside in stromal part of bone marrow and hold a vast clinical application. They have the ability of self-renewal and can be differentiated into a variety of cells. Mesenchymal stem cells differentiated into cardiomyocytes, osteocytes, adipocytes and chondrocytes.3 In cardiac regeneration, mesenchymal stem cells have the capability to distinguish towards cardiomyocytes both in vitro and in vivo.4