Nano-crystals a comprehensive review on formulation and application perspectives

Abstract

A majority of recently invented medications have been discovered to be poorly water-soluble and cause delays in the formulation and development of dosage forms. Solubility has been a major problem for BCS classes II and IV. As a result, nanotechnology may be useful in resolving the solubility problem. This review will cover Nanocrystals, as well as the numerous methodologies employed in their formulation and their application. Nanocrystals are nanometre-sized drug particles of a poorly water-soluble compound. They are distinct from polymeric nanoparticles in that they are entirely made up of the drug. Nanocrystals can be implemented to increase the rate of dissolution and saturation solubility of active pharmaceutical ingredients. Milling, high-pressure homogenization, precipitation, and combination methods such as Nanoedge andSmartCrystal, are among the approaches available for its formulation. The transition of nanocrystals into final formulations, as well as future nanocrystal trends, are also discussed.